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Claims for Patent: 9,050,308

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Claims for Patent: 9,050,308

Title:DPA-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form
Abstract: DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented.
Inventor(s): Maines; Timothy J. (Potomac, MD), Machielse; Bernardus N M (North Potomac, MD), Mehta; Bharat M. (Mendham, NJ), Wisler; Gerald L. (Windermere, FL), Davidson; Michael H. (Highland Park, IL), Wood; Peter Ralph (Cotherstone, GB)
Assignee: Omthera Pharmaceuticals, Inc. (Princeton, NJ) Chrysalis Pharma AG (Sacheln, CH)
Application Number:13/734,846
Patent Claims: 1. A method of treating severe hypertriglyceridemia, comprising: orally administering a dose of 2-4 grams per day of a pharmaceutical composition comprising: EPA, in a weight percent amount of 50% to 60%; DHA, in a weight percent amount of 17% to 23%; and DPA, in a weight percent amount of 1% to 8%; wherein at least 90% by weight of the polyunsaturated fatty acid in the composition is present in the free acid form, to a patient having pre-treatment serum or plasma triglyceride levels.gtoreq.500 mg/dL, for a duration effective to reduce serum or plasma triglycerides below pre-treatment levels.

2. The method of claim 1, wherein at least 95% by weight of the polyunsaturated fatty acid in the composition is present in the free acid form.

3. The method of claim 1, wherein DPA is present in a weight percent amount of at least 1.5%.

4. The method of claim 3, wherein DPA is present in a weight percent amount of at least 2%.

5. The method of claim 4, wherein DPA is present in a weight percent amount of at least 2.5%.

6. The method of claim 5, wherein DPA is present in a weight percent amount of at least 3%.

7. The method of claim 6, wherein DPA is present in a weight percent amount of at least 3.5%.

8. The method of claim 7, wherein DPA is present in a weight percent amount of at least 4%.

9. The method of claim 7, wherein DPA is present in a weight percent amount of at least 4.5%.

10. The method of claim 1, wherein the dose is 2 grams per day.

11. The method of claim 1, wherein the dose is 4 grams per day.
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