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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
US Department of Justice
Johnson and Johnson

Generated: June 23, 2018

DrugPatentWatch Database Preview

Claims for Patent: 8,623,868

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Summary for Patent: 8,623,868
Title:Processes of making and using pharmaceutical formulations of antineoplastic agents
Abstract: In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine or mixtures thereof; a lyophilized powder comprising said pharmaceutical formulation, and articles of manufacture thereof.
Inventor(s): Ugwu; Sydney (Gurnee, IL), Radhakrishnan; Vinay (Thousand Oaks, CA), Ihnat; Peter M. (Brooklyn, NY), Witchey-Lakshmanan; Lenore C. (Piscataway, NJ)
Assignee: Merck Sharp & Dohme Corp. (Rahway, NJ)
Application Number:13/290,251
Patent Claims: 1. A lyophilized powder comprising temozolomide or a pharmaceutically acceptable salt thereof; and L-threonine.

2. The lyophilized powder of claim 1, further comprising: mannitol, a citrate buffer and hydrochloric acid.

3. The lyophilized powder of claim 2, further comprising a polysorbate 80.

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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Farmers Insurance
US Army
Federal Trade Commission

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