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Claims for Patent: 8,586,551

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Claims for Patent: 8,586,551

Title:18-membered macrocycles and analogs thereof
Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
Inventor(s): Shue; Youe-Kong (Carlsbad, CA), Hwang; Chan-Kou (San Diego, CA), Chiu; Yu-Hung (San Diego, CA), Romero; Alex (San Diego, CA), Babakhani; Farah (San Diego, CA), Sears; Pamela (San Diego, CA), Okumu; Franklin (Oakland, CA)
Assignee: Optimer Pharmaceuticals, Inc. (Jersey City, NJ)
Application Number:12/551,056
Patent Claims: 1. An isolated compound having the formula: ##STR00023## free from other stereoisomers of the compound.

2. A pharmaceutical composition comprising the compound of claim 1 or pharmaceutically acceptable salt thereof.

3. The pharmaceutical composition of claim 2, further comprising one or more pharmaceutically acceptable carriers.

4. The pharmaceutical composition of claim 3, wherein the composition is formulated for oral administration.

5. The pharmaceutical composition of claim 4, wherein the composition is formulated as a tablet.

6. A pharmaceutical composition consisting of the compound of claim 1 or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers.
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