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Claims for Patent: 8,575,149

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Claims for Patent: 8,575,149

Title:5HT2C receptor modulators
Abstract: The present invention relates to novel compounds of Formula (I): ##STR00001## which act as 5HT.sub.2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
Inventor(s): Smith; Jeffrey (San Diego, CA), Smith; Brian (San Diego, CA)
Assignee: Arena Pharmaceuticals, Inc. (San Diego, CA)
Application Number:13/620,204
Patent Claims: 1. A method for treating a subject for a disease or disorder for which weight loss is indicated, said method comprising the steps of: administering to said subject a pharmaceutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 wherein said subject has at least one weight related condition chosen from hypertension, cardiovascular disease, and diabetes.

3. The method of claim 1 wherein said subject has at least one weight related condition chosen from hypertension and diabetes.

4. The method of claim 1, further comprising advising said subject to increase physical activity.

5. The method of claim 1, further comprising advising said subject to reduce dietary fat content.

6. The method of claim 1, further comprising advising said subject to consume fewer calories.

7. The method of claim 1, wherein prior to said administration, the subject had a BMI of greater than 30 kg/m.sup.2.

8. The method of claim 1, wherein prior to said administration, the subject had a BMI ranging from 25 to 30 kg/m.sup.2.

9. A method of weight management in a patient in need thereof said method comprising the steps of: administering to said subject a pharmaceutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt thereof.

10. The method of claim 9, wherein prior to said administration, the subject had a BMI of greater than 30 kg/m.sup.2.

11. The method of claim 9, wherein prior to said administration, the subject had a BMI ranging from 25 to 30 kg/m.sup.2.

12. The method of claim 9 wherein said subject has at least one weight related condition chosen from hypertension, cardiovascular disease, and diabetes.

13. The method of claim 12 wherein said subject has at least one weight related condition chosen from hypertension and diabetes.

14. The method of claim 9, further comprising advising said subject to increase physical activity.

15. The method of claim 9, further comprising advising said subject to reduce dietary fat content.

16. The method of claim 9, further comprising advising said subject to consume fewer calories.
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