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Claims for Patent: 8,156,936

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Claims for Patent: 8,156,936

Title:Unit dose capsules and dry powder inhaler
Abstract: Described are dry powder inhalers comprising an intake section, a mixing section and a mouthpiece. The mixing section can accommodate a capsule having a top keying portion and containing a dry powder medicament. The top keying portion of the capsules may fit within complementary keying structures in inhaler mixing sections.
Inventor(s): Steiner; Solomon S. (Mount Kisco, NY), Fog; Per B. (Bedford Hills, NY), Poole; Trent (South Amherst, MA), Feldstein; Robert (Yonkers, NY)
Assignee: MannKind Corporation (Valencia, CA)
Application Number:11/934,643
Patent Claims: 1. A medicament capsule for an inhaler, comprising a first element and a second element, and a locking mechanism; wherein each element is structurally configured to have a chamber with an open end and a closed end, an inner surface, an outer surface, at least one opening in its wall, and at least one keying surface that extends from the outer surface of one of the elements, and wherein the first element and second element fit together to form the capsule and are moveable relative to each other.

2. The medicament capsule of claim 1, wherein the medicament capsule is structurally configured for a dry powder inhaler.

3. The medicament capsule of claim 1, wherein the locking mechanism comprises mating features on the surfaces of the first element and second element.

4. The medicament capsule of claim 1, wherein the at least one keying feature is provided on the first element and/or second element and structurally configured to mate with an inhaler.

5. The medicament capsule of claim 1, wherein the at least one keying feature is provided at the closed end of the first and/or second element and operably configured to protrude on the longitudinal axis of the capsule.

6. A medicament capsule for an inhaler, comprising a first element and a second element, and a grasping surface; wherein each element is structurally configured to have a chamber with an open end and a closed end, an inner surface, an outer surface, at least one opening in its wall, and a keying surface that extends from the outer surface, and wherein the first element and second element fit together to form the capsule and are moveable relative to each other.

7. The medicament capsule of claim 6, wherein the grasping surface is structurally configured with the keying surface of the first element or second element.

8. The medicament capsule of claim 6, wherein the grasping surface is structurally configured to identify proper placement of the capsule in the inhaler.

9. The medicament capsule of claim 6, wherein the grasping surface is structurally configured to identify the drug formulation.

10. The medicament capsule of claim 6, wherein the grasping surface is structurally configured in the shape of a square, rectangle, circle, a disc, a dish, a plate, or saucer-like structure, with or without a flat surface.

11. A medicament capsule for an inhaler, which comprises a first element and a second element, and a grasping surface; wherein each element is structurally configured to have a chamber with an open end and a closed end, an inner surface, an outer surface, at least one opening in its wall, and a keying surface that extends from the outer surface, and wherein the first element and second element fit snugly together to form the capsule and are moveable relative to each other; wherein at least one opening in the wall of the first element can be placed in alignment with at least one opening in the wall of the second element.

12. The medicament capsule of claim 11, wherein the at least one opening in the first element and the at least one opening in the second element are configurable from a non-aligned position to an aligned position; and optionally are reconfigurable to non-aligned position.

13. A medicament capsule for an inhaler, comprising a first element and a second element, and a grasping surface; wherein each element is structurally configured to have a mixing chamber with an open end and a closed end, an inner surface, an outer surface, at least one opening in its wall, and a keying surface that extends from the outer surface, and wherein the first element and second element fit together to form the capsule, are moveable relative to each other, and at least one protrusion extending from the inner surface of the closed end, and the chamber is structurally configured to fluidize a medicament by cyclonic air flow through the capsule.

14. The medicament capsule of claim 13, wherein the at least one opening in the first element and the at least one opening in the second element are configurable from a non-aligned position to an aligned position; and optionally are reconfigurable to non-aligned position; wherein in the aligned position the medicament is enabled to be fluidized.

15. The medicament capsule of claim 14, wherein the at least one opening in the first element and the at least one opening in the second element are configurable from a non-aligned position to an aligned position by rotation.

16. The medicament capsule of claim 14, wherein the capsule further comprises mating means to hold the first element and the second element together.

17. The medicament capsule of claim 13, wherein the inner surface of the capsule and the at least one opening meet in a chamfered, or beveled edge configuration.

18. The medicament capsule of claim 13, wherein the mixing chamber protrusions enable deagglomeration and fluidization of a powder medicament when air flows therethrough.

19. The medicament capsule of claim 13, wherein the protrusions are cone structures.

20. A medicament capsule for an inhaler, comprising a first element and a second element, a securing mechanism and a grasping surface; wherein each element is structurally configured to have a chamber with an open end and a closed end, an inner surface, an outer surface, at least one opening in its wall, and a keying surface that extends from the outer surface, and wherein the first element and second element fit snugly together to form the capsule and are moveable relative to each other.

21. The medicament capsule of claim 20, wherein the securing mechanism is provided in the outer surface of the capsule.

22. The medicament capsule of claim 20, wherein the securing mechanism is provided in a keying surface.

23. The medicament capsule of claim 21, wherein the securing mechanism is structurally configured to engage with a securing mechanism in the inhaler.

24. The medicament capsule of claim 21, wherein the securing mechanism comprises snap rings.

25. The medicament capsule of claim 21, wherein the securing mechanism provides tactile sensation and capsule securement during installation of the capsule in the inhaler.

26. A capsule for holding a medicament in a dry powder inhaler, comprising a first element, a second element and a capsule interior, wherein the first element and the second element define at least a portion of the capsule interior, the first element comprising at least one keying surface to align the capsule in the dry powder inhaler, wherein said at least one keying surface comprises a protrusion or a slot which enables identification of the capsule, or mates with a complementary keying surface in the inhaler and wherein the second element comprises at least one additional keying surface to align the capsule in the dry powder inhaler, and wherein the at least one additional keying surface comprises an additional protrusion or slot which enables identification of the capsule, or mates with an additional complementary keying surface in the inhaler.

27. The medicament capsule of claim 1, further comprising a powdered medicament in the medicament capsule.

28. The medicament capsule of claim 6, further comprising a powdered medicament in the medicament capsule.

29. The medicament capsule of claim 11, further comprising a powdered medicament in the medicament capsule.

30. The medicament capsule of claim 20, further comprising a powdered medicament in the medicament capsule.

31. The capsule of claim 26, further comprising a powdered medicament in the capsule.
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