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|Title:||Methods for concomitant administration of colchicine and macrolide antibiotics|
|Abstract:||Methods for concomitant administration of colchicine together with one or more macrolide antibiotics, e.g., clarithromycin, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits.|
|Inventor(s):||Davis; Matthew W. (Erwinna, PA)|
|Assignee:||Mutual Pharmaceutical Company, Inc. (Philadelphia, PA)|
1. A method of using colchicine for the treatment of Familial Mediterranean Fever in a human patient in need of treatment thereof, said method comprising: orally
administering a reduced colchicine dosage amount to the human patient in need of treatment for Familial Mediterranean Fever who is concomitantly receiving administration of clarithromycin within 1 to 2 days of oral administration of colchicine, wherein
the reduced colchicine dosage amount is reduced compared to a daily dosage amount to be administered in the absence of concomitant clarithromycin and is about 0.3 mg of colchicine twice per day, wherein the daily dosage amount of colchicine in the
absence of concomitant clarithromycin is: TABLE-US-00009 Daily dosage amount Age Usual Maximum Adults and children >12 years 1.2 mg 2.4 mg Children >6 to 12 years 0.9 mg 1.8 mg Children 4 to 6 years 0.3 mg 1.8 mg
and wherein the dose of clarithromycin is 250 mg twice per day.
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