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|Title:||Methods for concomitant administration of colchicine and a second active agent|
|Abstract:||Methods for concomitant administration of colchicine together with one or more second active agents, e.g., ketoconazole and ritonavir, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for concomitant administration of colchicine together with second active agents are also provided.|
|Inventor(s):||Davis; Matthew W. (Erwinna, PA)|
|Assignee:||Mutual Pharmaceutical Company, Inc. (Philadelphia, PA)|
1. A method of treating a patient in need of treatment for the prophylaxis of gout flares with colchicine, comprising orally administering to the patient in need of treatment
for the prophylaxis of gout flares, an adjusted daily dosage amount of colchicine to the patient who is receiving concomitant administration of 200 mg per day of ritonavir, wherein the adjusted daily dosage amount of colchicine is 25% to 50% of 0.6 mg
twice per day or 0.6 mg once per day, which is an amount of colchicine suitable for the patient if the patient were not receiving concomitant ritonavir.
2. The method of claim 1, further comprising carefully monitoring the individual for potential toxicity.
3. The method of claim 1, wherein the adjusted daily dosage amount of colchicine is 25% of an intended daily dosage amount of colchicine.
4. The method of claim 1, wherein the adjusted daily dosage amount of colchicine is 50% of an intended daily dosage amount of colchicine.
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