|Title:||Multiple antigen glycopeptide carbohydrate, vaccine comprising the same and use thereof|
|Abstract:||The invention of the present application relates to a method for obtaining antibodies directed against a carbohydrate moiety contained in a carbohydrate peptide conjugate, by administering to a subject a composition containing a carbohydrate peptide conjugate and collecting the antibodies directed against the said carbohydrate moiety from a serum previously obtained from the subject.|
|Inventor(s):||Bay; Sylvie (Paris, FR), Cantacuzene; Daniele (Paris, FR), Leclerc; Claude (Paris, FR), Lo-Man; Richard (Paris, FR)|
|Assignee:||Institut Pasteur (Paris, FR)|
|Patent Claims:||1. A method for obtaining antibodies directed against a carbohydrate moiety (B) contained in a carbohydrate peptide conjugate, comprising: a) administering to a human or an animal body a composition comprising a carbohydrate peptide conjugate having a carbohydrate content ranging from 33% (w/w) to 90% (w/w), said conjugate being selected from the group of conjugates of formulae (a) to (f) below: ##STR00002## wherein: K is a lysyl residue, T is a CD4.sup.+ T cell epitope, and B and Tn is a Tn antigen selected from the group consisting of .alpha.-Gal-Nac-Ser, .alpha.-Gal-Nac-Thr, .beta.-Gal-( 1-3)-.alpha.-Gal-Nac-Ser, .beta.-Gal(1-3).alpha.-Gal-Nac-Thr(.alpha.-Gal-Nac-Ser/Thr).sub.2, (.alpha.-Gal-Nac-Ser/Thr).sub.3 and (.alpha.-Gal-Nac-Ser/Thr).sub.6; and b) collecting the antibodies directed against the said carbohydrate moiety (B) from a serum obtained from said human or animal body.|
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