.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 7,671,031

« Back to Dashboard

Claims for Patent: 7,671,031

Title:Abuse-resistant amphetamine prodrugs
Abstract:The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
Inventor(s): Mickle; Travis (Coralville, IA), Krishnan; Suma (Belvedere, CA), Bishop; Barney (Annandale, VA), Lauderback; Christopher (Blacksburg, VA), Moncrief; James Scott (Christiansburg, VA), Oberlender; Robert (Blacksburg, VA), Piccariello; Thomas (Blacksburg, VA), Paul; Bernhard J. (Lexington, MA), Verbicky; Christopher A. (Broadalbin, NY)
Assignee: Shire LLC (Florence, KY)
Application Number:12/202,159
Patent Claims: 1. A method, in a subject in need thereof, of delivering an amphetamine, said method comprising administering to said subject L-lysine-d-amphetamine or a salt thereof.

2. A method as defined in claim 1, wherein said subject suffers from attention deficit hyperactivity disorder.

3. A method as defined in claim 1, wherein said subject is an adult human.

4. A method as defined in claim 1, wherein said subject is a human who is not an adult.

5. A method as defined in claim 1, wherein said L-lysine-d-amphetamine is in the form of a salt.

6. A method as defined in claim 5, wherein said salt is a mesylate salt.

7. A method as defined in claim 6, wherein said salt is a dimesylate salt.

8. A method as defined in claim 5, wherein said salt is a hydrochloride salt.

9. A method as defined in claim 1, wherein said L-lysine-d-amphetamine or salt thereof is in a dosage form selected from the group consisting of a tablet, capsule, caplet, oral solution, and oral suspension.

10. A method as defined in claim 9, wherein the amount of said L-lysine-d-amphetamine or salt thereof in said dosage form is from about 2.5 to about 500 mg.

11. A method as defined in claim 10, wherein said amount is from about 5 to about 500 mg.

12. A method as defined in claim 11, wherein the amount is from about 10 to about 100 mg.

13. A method as defined in claim 12, wherein said amount is from 25 to 75 mg.

14. A method as defined in claim 13, wherein said amount is 30 mg.

15. A method as defined in claim 13, wherein said amount is 50 mg.

16. A method as defined in claim 13, wherein said amount is 70 mg.

17. A method, in a subject in need thereof, of delivering an amphetamine, said method comprising administering to said subject a composition comprising L-lysine-d-amphetamine or a salt thereof having a covalent bond between an amphetamine moiety and a lysine moiety, and hydrolysing said covalent bond.

18. A method as defined in claim 17, wherein said subject suffers from attention deficit hyperactivity disorder.

19. A method as defined in claim 17, wherein said subject is an adult human.

20. A method as defined in claim 17, wherein said subject is a human who is not an adult.

21. A method as defined in claim 17, wherein said L-lysine-d-amphetamine is in the form of a salt.

22. A method as defined in claim 21, wherein said salt is a mesylate salt.

23. A method as defined in claim 22, wherein said salt is a dimesylate salt.

24. A method as defined in claim 21, wherein said salt is a hydrochloride salt.

25. A method as defined in claim 17, wherein said L-lysine-d-amphetamine or salt thereof is in a dosage form selected from the group consisting of a tablet, capsule, caplet, oral solution, and oral suspension.

26. A method as defined in claim 25, wherein the amount of said L-lysine-d-amphetamine or salt thereof in said dosage form is from about 2.5 to about 500 mg.

27. A method as defined in claim 26, wherein said amount is from about 5 to about 500 mg.

28. A method as defined in claim 27, wherein the amount is from about 10 to about 100 mg.

29. A method as defined in claim 28, wherein said amount is from 25 to 75 mg.

30. A method as defined in claim 29, wherein said amount is 30 mg.

31. A method as defined in claim 29, wherein said amount is 50 mg.

32. A method as defined in claim 29, wherein said amount is 70 mg.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc