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Claims for Patent: 7,488,827

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Claims for Patent: 7,488,827

Title:Muscarinic acetylcholine receptor antagonists
Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
Inventor(s): Laine; Damane I. (King of Prussia, PA), Palovich; Michael R. (King of Prussia, PA), McCleland; Brent W. (King of Prussia, PA), Neipp; Christopher E. (King of Prussia, PA), Thomas; Sonia M. (King of Prussia, PA)
Assignee: Glaxo Group Limited (Greenford, Middlesex, GB)
Application Number:11/774,867
Patent Claims: 1. The compound which is 4-[hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicycl- o[2.2.2]octane bromide.

2. A pharmaceutical composition comprising 4-[hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicycl- o[2.2.2]octane bromide and a pharmaceutically acceptable carrier thereof.

3. The compound ##STR00047## wherein X is a pharmaceutically acceptable anion.

4. The compound according to claim 3 wherein the pharmaceutically acceptable anion is chloride, bromide, iodide, hydroxide, sulfate, nitrate, phosphate, acetate, trifluoroacetate, fumarate, citrate, tartrate, oxalate, succinate, mandelate, methanesulfonate or p-toluenesulfonate.

5. The compound according to claim 3 wherein the pharmaceutically acceptable anion is bromide.

6. The compound according to claim 3 wherein the pharmaceutically acceptable anion is iodide.

7. A pharmaceutical composition comprising the compound ##STR00048## wherein X is a pharmaceutically acceptable anion, and a pharmaceutically acceptable carrier thereof.

8. The composition according to claim 7 wherein the pharmaceutically acceptable anion is chloride, bromide, iodide, hydroxide, sulfate, nitrate, phosphate, acetate, trifluoroacetate, fumarate, citrate, tartrate, oxalate, succinate, mandelate, methanesulfonate or p-toluenesulfonate.

9. The composition according to claim 7 wherein the pharmaceutically acceptable anion is bromide.

10. The composition according to claim 7 wherein the pharmaceutically acceptable anion is iodide.

11. A pharmaceutical composition according to claim 2 in a form suitable for administration by oral or nasal inhalation.

12. A pharmaceutical composition according to claim 11 wherein the form is suitable for administration by inhalation via a medicament dispenser selected from a reservoir dry powder inhaler, multi-dose dry powder inhaler, or a metered dose inhaler.

13. A pharmaceutical composition according to claim 2 which is a dry powder composition.

14. A pharmaceutical composition according to claim 2 wherein the pharmaceutically acceptable carrier is lactose.

15. A pharmaceutical composition according to claim 7 in a form suitable for administration by oral or nasal inhalation.

16. A pharmaceutical composition according to claim 15 wherein the form is suitable for administration by inhalation via a medicament dispenser selected from a reservoir dry powder inhaler, a multi-dose dry powder inhaler, or a metered dose inhaler.

17. A pharmaceutical composition according to claim 7 which is a dry powder composition.

18. A pharmaceutical composition according to claim 7 wherein the pharmaceutically acceptable carrier is lactose.
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