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Claims for Patent: 6,340,689

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Claims for Patent: 6,340,689

Title: Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria
Abstract:A method of treating an atypical upper respiratory pathogenic bacteria comprising administering a gemifloxacin compound is disclosed.
Inventor(s): Dubois; Jacques (Fleuramont, CA), St-Pierre; Claude (St-Elie d'Orford, CA)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:09/395,851
Patent Claims: 1. A method for modulating metabolism of an atypical upper respiratory pathogexnic bacteria comprising the step of contacting atypical upper respiratory pathogenic bacteria with an antibacterially effective amount of a composition comprising a gemifloxacin compound, or an antibacterially effective derivative thereof, and wherein said atypical, upper respiratory pathogenic bacteria is selected from the group consisting of: a L. dumoffii strain, a L. longbeacheae strain, a L. micdadei strain, a L. oakridgensis strain, a L. feelei strain, a L. anisa strain, a L. sainthelensi strain, a L. bozemanii strain, a L. gormanii strain, a L. wadsworthii strain, and a L. jordanis strain.

2. The method of claim 1 wherein said modulating metabolism is inhibiting growth of said bacteria.

3. The method of claim 1 wherein said modulating metabolism is killing said bacteria.

4. The method of claim 1 wherein said contacting said bacteria comprises the further step of introducing said composition into a mammal.

5. A method of treating or preventing a bacterial infection by atypical upper respiratory pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a gemifloxacin compound, or an antibacterially effective derivative thereof, to a mammal suspected of having or being at risk of having an infection with atypical upper respiratory pathogenic bacteria, and wherein said atypical upper respiratory pathogenic bacteria is selected from the group consisting of: a L. dumoffii strain, a L. longbeacheae strain, a L. micdadei strain, a L. oakridgensis strain, a L. feelei strain, a L. anisa strain, a L. sainthelensi strain, a L. bozemanii strain, a L. gormanii strain, a L. wadsworthii strain, and a L. jordanis strain.

6. The method of claim 1 or 5 wherein said contacting is performed once daily.

7. The method according to claim 1 or 5 wherein the gemifloxacin compound is gemifloxacin or a pharmaceutically acceptable salt thereof.

8. The method according to claim 7 wherein the gemifloxacin compound is gemifloxacin mesylate or a hydrate thereof.

9. The method according to claim 8 wherein the gemifloxacin compound is gemifloxacin mesylate sesquihydrate.
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