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Claims for Patent: 5,817,655

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Claims for Patent: 5,817,655

Title: Methods of treatment using a thieno-benzodiazepine
Abstract:2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno -[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system. The compound has the following structure: ##STR1##
Inventor(s): Chakrabarti; Jiban Kumar (Camberley, GB2), Hotten; Terrence Micharl (Farnborough, GB2), Tupper; David Edward (Reading, GB2)
Assignee: Eli Lilly and Company (Indianapolis, IN) Eli Lilly and Company Limited (Basingstoke, GB2)
Application Number:08/748,292
Patent Claims: 1. A method of treating a patient suffering from or susceptible to a psychosis selected from the group consisting of Delirium; Organic Delusional Disorder; Multi-infarct Dementia, With Delirium; Multi-infarct Dementia, With Delusions; Major Depression, Recurrent With Psychotic Features; and Organic Hallucinosis, comprising administering to the patient an amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof, that is effective to treat the psychosis.

2. A method of claim 1 wherein the effective amount is from 1 to 20 mg per day of 2-methyl-4-(4-methyl -1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof.

3. A method for treating a patient suffering from or susceptible to a psychosis selected from the group consisting of Delirium; Psychotic Disorder Due to a Medical Condition, With Delusions; Psychotic Disorder Due to a Medical Condition, With Hallucinations; Vascular Dementia, With Delirium; Vascular Dementia, With Delusions; and Severe Recurrent Major Depressive Disorder With Psychotic Features; comprising administering to the patient an amount of 2-methyl -4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof, that is effective to treat the psychosis.

4. A method of claim 3 wherein the effective amount is from 1 to 20 mg per day.

5. A method for treating a patient suffering from the psychotic condition called Primary Degenerative Dementia of the Alzheimer Type, Presenile Onset, With Delusions, comprising administering to the patient an amount of 2-methyl -4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof, that is effective to treat the condition.

6. The method of claim 5 wherein the effective amount is from 1 to 20 mg per day.
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