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Claims for Patent: 4,915,950

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Claims for Patent: 4,915,950

Title: Printed transdermal drug delivery device
Abstract:A method for making transdermal drug delivery devices is provided which includes: laminating an adsorbent source layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive; depositing a drug in liquid form on one face of the source layer; laminating an anchor adhesive layer to the opposing face of the source layer; and applying a drug-impermeable backing layer to the anchor adhesive, which backing layer then defines the upper surface of the device. The invention also encompasses transdermal drug delivery devices having a source layer in contact with and contained between anchor and contact adhesive layers, with a backing layer adjacent the anchor adhesive defining the upper surface of the device.
Inventor(s): Miranda; Jesus (Menlo Park, CA), Cleary; Gary W. (San Mateo, CA)
Assignee: Cygnus Research Corporation (Redwood City, CA)
Application Number:07/215,074
Patent Claims: 1. A method for making a transdermal delivery device, comprising:

(a) laminating an adsorbent source layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive layer, the contact adhesive layer comprised of a material that is permeable to the drug and which defines a basal surface for adhesion to skin;

(b) printing a drug in liquid form onto the adsorbent fabric layer;

(c) laminating an anchor adhesive layer to the source layer; and

(d) applying a backing layer to the anchor adhesive layer which defines the upper surface of the device and is substantially impermeable to the drug.

2. The method of claim 1, further including (e) applying a release liner layer that covers the lower surface defined by the contact adhesive layer, the release liner adapted to be removed from the device prior to use to expose the lower surface of the contact adhesive layer.

3. The method of claim 1, wherein the drug is nicotine.

4. The method of claim 3, wherein the nicotine is in free base form.

5. The method of claim 3, wherein the nicotine is in salt form.

6. The method of claim 1, wherein the drug is nitroglycerin.

7. The method of claim 1, wherein the drug is fentanyl.

8. The method of claim 7, wherein the drug is fentanyl base.

9. The method of claim 7, wherein the drug is a pharmaceutically acceptable salt of fentanyl.

10. The method of claim 1, wherein said drug in liquid form is deposited on the source layer with a percutaneous absorption enhancer that increases the permeability of the skin to the drug.

11. A method for making a transdermal delivery device comprising:

(a) laminating an adsorbent fabric layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive layer, the contact adhesive layer comprised of a material that is permeable to the drug and which defines a basal surface for adhesion to skin;

(b) printing an enhancer onto the adsorbent fabric layer;

(c) laminating an anchor adhesive layer to the fabric layer; and

(d) applying a backing layer to the anchor adhesive layer which defines the upper surface of the device and is substantially impermeable to the drug,

wherein prior to said laminating, the drug is incorporated into the anchor adhesive layer, the contact adhesive layer, or both.

12. A method for making a fragrance-releasing device, comprising:

(a) laminating an adsorbent fabric layer, adapted to initially retain a fragrance in liquid form, to a pressure-sensitive, pharmaceutically acceptable contact adhesive layer which defines a basal surface;

(b) printing a fragrance in liquid form onto the adsorbent fabric layer, whereby the fragrance is incorporated and initially retained therein;

(c) laminating an anchor adhesive layer to the fabric layer, the anchor adhesive layer comprised of a material that is substantially pormeable to the fragrance; and

(d) applying a backing layer to the anchor adhesive layer which defines the upper surface of the device and is substantially permeable to the fragrance.
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