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Claims for Patent: 4,883,790

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Claims for Patent: 4,883,790

Title: Wavelength-specific cytotoxic agents
Abstract:A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-720 nanometers is useful in treating disorders which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light. The use of the Gp of the invention permits the irradiation to comprise wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to receptor ligands or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.
Inventor(s): Levy; Julia G. (Vancouver, CA), Dolphin; David (Vancouver, CA), Chow; Jack K. (Burnaby, CA)
Assignee: University of British Columbia (Vancouver, CA)
Application Number:07/041,680
Patent Claims: 1. A method to impair the functioning of target cells to which a hydro-monobenzoporphyrin (Gp) having a light absorption maximum between 670-720 nm is attracted, which method comprises

administering to a mammal in need of such treatment an effective amount of said Gp; and

irradiating said target cells with radiation having a wavelength contained in the range of 670-720 nm,

wherein the Gp is selected from the group consisting of ##STR1## wherein each R.sup.3 is independently [2-carboxyethyl or a derivative thereof] lower alkyl (1-4C) or omegacarboxyalkyl (2-6C) or the esters (1-6C) or amides (1-10C) thereof; and

each R.sup.1 and R.sup.2 is independently selected from the group consisting of carboxy, carbalkoxy (1-6C), alkyl (1-6C) sulfone, and aryl.

2. The method of claim 1 wherein each R.sup.1 and R.sup.2 is independently selected from the group consisting of carboxy and carbalkoxy (1-6C).

3. The method of claim 2 wherein each R.sup.3 is independently selected from the group consisting of omegacarboxyalkyl (2-6C) and the esters (1-6C) thereof.

4. The method of claim 3 wherein the Gp has the formula selected from formulas 1 and 2.

5. The method of claim 3 wherein the Gp has the formula selected from formulas 3 and 4.

6. The method of claim 3 wherein the Gp has the formula selected from formulas 5 and 6.

7. The method of claim 1 wherein R.sup.1 and/or R.sup.2 is conjugated to a linker-moiety.

8. The method of claim 1 wherein each R.sup.3 is independently selected from the group consisting of omegacarboxyalkyl (2-6C) and the esters (1-6C) thereof.

9. The method of claim 1 wherein the target cells are present on the skin.

10. The method of claim 9 wherein the target cells are superficial tumors.

11. The method of claim 9 wherein each R.sup.1 and R.sup.2 is selected from the group consisting of carboxy, carbalkoxy(1-6C), alkyl(1-6C) sulfonate, alkyl(1-6C) sulfone, and aryl, optionally conjugated to a linker moiety.
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