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Claims for Patent: 4,314,081

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Claims for Patent: 4,314,081

Title: Arloxyphenylpropylamines
Abstract:3-Aryloxy-3-phenylpropylamines and acid additions salts thereof, useful as psychotropic agents, particularly as anti-depressants.
Inventor(s): Molloy; Bryan B. (Indianapolis, IN), Schmiegel; Klaus K. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:05/432,379
Patent Claims: 1. A compound of the formula ##STR7## wherein each R' is independently H or CH.sub.3 and R is m- or p-chlorophenyl, o-, m-, or p-methoxyphenyl, phenyl, o- or m-fluorophenyl, o- or p-tolyl, 2,4-difluorophenyl or p-trifluoromethylphenyl and acid addition salts formed with pharmaceutically-acceptable acids.

2. A compound according to claim 1, said compound being N-methyl 3-(o-tolyloxy)-3-phenylpropylamine and pharmaceutically-acceptable acid addition salts thereof.

3. A compound according to claim 2, said compond being N-methyl 3-(o-tolyloxy)-3-phenylpropylamine hydrochloride.

4. A compound according to claim 1, said compound being N-methyl 3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, and pharmaceutically-acceptable acid addition salts thereof formed with non-toxic acids.

5. A compound according to claim 4, said compound being N-methyl 3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride.

6. A compound according to claim 1, said compound being N-methyl 3-(o-methoxyphenoxy)-3-phenylpropylamine, and pharmaceutically-acceptable acid addition salts thereof formed with non-toxic acids.

7. A compound according to claim 1, said compound being N-methyl 3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride.

8. A compound according to claim 1, said compound being N-methyl 3-(2,4-difluorophenoxy)-3-phenylpropylamine.

9. A compound according to claim 8, said compound being N-methyl 3-(m-fluorophenoxy)-3-phenylpropylamine oxalate.
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