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Claims for Patent: 4,100,274

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Claims for Patent: 4,100,274

Title: Polypeptide
Abstract:The disclosure relates to novel luliberin analogues which possess luliberin agonist activity, to processes for their manufacture and to compositions containing them. Typical of the peptides disclosed is ##STR1## in which A is D-Phe, D-Tyr(Me) or D-Ser(Bu.sup.t).
Inventor(s): Dutta; Anand Swaroop (Macclesfield, GB2), Furr; Barrington John Albert (Macclesfield, GB2), Giles; Michael Brian (Macclesfield, GB2)
Assignee: Imperial Chemical Industries Limited (London, GB2)
Application Number:05/790,003
Patent Claims: 1. A polypeptide of the formula: ##STR8## in which A is selected from the group consisting of D-Tyr(Me), D-Ser(Bu.sup.t) and D-Phe, B is selected from the group consisting of Leu or MeLeu, E is Azgly and F is an amino radical, and the pharmaceutically- and veterinarily-acceptable acid-addition salts thereof.

2. A polypeptide as claimed in claim 1 which is ##STR9##

3. A polypeptide as claimed in claim 1 which is ##STR10##

4. A polypeptide as claimed in claim 1 which is ##STR11##

5. A pharmaceutical or veterinary composition comprising as active ingredient an effective amount of a polypeptide as claimed in claim 1 in association with a major amount of a nontoxic pharmaceutically- or veterinarily-acceptible diluent or carrier.

6. A method of controlling and/or improving reproduction in warm-blooded animals which comprises administration of an effective amount of a polypeptide as claimed in claim 1.
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