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Last Updated: April 25, 2025

Drugs in MeSH Category Filaricides


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Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Lederle HETRAZAN diethylcarbamazine citrate TABLET;ORAL 006459-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Filaricides Market Analysis and Financial Projection

The global market for filariasis treatments and its associated patent landscape reveal critical insights into pharmaceutical trends for neglected tropical diseases (NTDs). Below is a structured analysis of market dynamics and intellectual property developments for drugs classified under NLM MeSH: Filaricides.


Market Dynamics of Filaricides

The filariasis treatment market is experiencing robust growth, driven by increasing disease prevalence and public health interventions:

  • Market Growth:
    The market is projected to rise from USD 10.96 billion in 2023 to USD 28.68 billion by 2033, reflecting a 10.1% CAGR[1][5][11]. This expansion is fueled by rising infections in tropical regions, particularly Africa and South Asia, where Wuchereria bancrofti accounts for 99.4% of cases in India[1][5].

  • Key Drivers:

    • Mass Drug Administration (MDA) Programs: Annual doses of ivermectin, diethylcarbamazine (DEC), and albendazole form the backbone of WHO-recommended strategies, achieving microfilariae clearance rates up to 96% in triple-drug regimens[3][16].
    • Cost-Effectiveness: MDA alone costs USD 112 per DALY averted, making it 8% of India’s GDP per capita, while integrated vector control increases expenses to USD 1.83 per resident[8].
    • Government Initiatives: Programs like India’s National Filaria Prevention Programme (2020) and global funding for R&D aim to eliminate lymphatic filariasis by 2030[1][5].
  • Treatment Landscape:

    • First-Line Drugs: DEC, ivermectin, and albendazole dominate, with triple therapy (IDA) showing superior efficacy over dual regimens in clinical trials[3][16].
    • Emerging Therapies: AWZ1066S (Subiaco Associates) is a late-stage pipeline drug, while nanoparticle-based delivery systems and Wolbachia-targeting antibiotics like doxycycline are under exploration[1][7][15].
  • Regional Challenges:
    Unplanned urbanization and climate change amplify mosquito breeding, while co-endemicity with Loa loa in Africa complicates ivermectin use due to encephalopathy risks[15].


Patent Landscape for Filaricides

Patent activity for filaricides reflects broader trends in NTD research and commercialization barriers:

Aspect Key Findings
Global Patent Trends Lymphatic filariasis falls into the low-activity category, with <100 patent families filed between 1985–2014[2].
Leading Countries The U.S. (6,154 filings) and China (2,423) dominate, though 50% of patents are inactive, indicating low commercial viability[2][4].
Innovation Hubs U.S. universities (e.g., Columbia, Michigan) lead in core patent citations, focusing on drug delivery and combination therapies[4].
Evergreening Practices Pharma giants like AstraZeneca and Gilead extend monopolies via trivial formulation patents, delaying generic entry[14].

Challenges in Drug Development

  • Neglect in R&D: Only 0.6% of NTD-related patents target filariasis, with most investments directed toward diseases like dengue[2][4].
  • Generic Dominance: Generics constitute 70–80% of private-sector drug markets in LMICs, reducing incentives for novel filaricide development[12].
  • Diagnostic Gaps: PCR and ELISA-based tools remain underpatented despite their critical role in monitoring MDA outcomes[1][7].

Strategic Implications

  • Policy Priorities: Scaling MDA coverage and integrating vector control (e.g., insecticidal curtains) could accelerate elimination[8].
  • R&D Opportunities: Public-private partnerships are vital to advance therapies like moxidectin and gene-editing technologies[15].
  • Equity Concerns: Patent pooling and tiered pricing mechanisms are needed to ensure affordable access in low-income regions[14][12].

"The stagnation in filaricide patents underscores the paradox of NTDs: high burden, low commercial interest."
– Adapted from Springer Medizin’s analysis of NTD patent trends[2].

This interplay of market growth and innovation gaps highlights the need for sustained global collaboration to align economic incentives with public health priorities.

References

  1. https://www.futuremarketinsights.com/reports/filariasis-treatment-market
  2. https://www.springermedizin.de/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-w/15223934
  3. https://pmc.ncbi.nlm.nih.gov/articles/PMC10584738/
  4. https://www.scirp.org/journal/paperinformation?paperid=89601
  5. https://www.pharmiweb.com/press-release/2024-10-23/global-filariasis-treatment-market-to-reach-usd-2868-billion-by-2032-projected-to-grow-at-101-ca
  6. https://patents.google.com/patent/US8841330B2/en
  7. https://www.imarcgroup.com/filariasis-market
  8. https://pmc.ncbi.nlm.nih.gov/articles/PMC11649082/
  9. https://meshb.nlm.nih.gov/record/ui?ui=D008118
  10. https://www.youtube.com/watch?v=o6CTfdx85ys
  11. https://www.verifiedmarketreports.com/product/filariasis-treatment-market/
  12. https://pubmed.ncbi.nlm.nih.gov/24098644/
  13. https://meshb.nlm.nih.gov/record/ui?ui=D008117
  14. https://www.uclawsf.edu/2020/09/24/patent-drug-database/
  15. https://pubmed.ncbi.nlm.nih.gov/20847694/
  16. https://pubmed.ncbi.nlm.nih.gov/30403937/

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