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Last Updated: June 18, 2025

Drugs in MeSH Category Anesthetics, Inhalation


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Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Hospira HALOTHANE halothane LIQUID;INHALATION 083254-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Baxter Hlthcare ETHRANE enflurane LIQUID;INHALATION 017087-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Abbott ENFLURANE enflurane LIQUID;INHALATION 070803-001 Sep 8, 1987 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Halocarbon HALOTHANE halothane LIQUID;INHALATION 080810-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Bh HALOTHANE halothane LIQUID;INHALATION 084977-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Piramal Critical ISOFLURANE isoflurane LIQUID;INHALATION 074416-001 Sep 30, 1994 AN RX No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Wyeth Ayerst FLUOTHANE halothane LIQUID;INHALATION 011338-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Anesthetics, Inhalation Market Analysis and Financial Projection

The inhalation anesthetics market is experiencing robust growth driven by surgical demand and technological innovation, while the patent landscape reveals intense R&D focused on drug formulations and delivery systems.

Market Size and Growth Projections

The global inhalation anesthesia market is valued at USD 1.44–1.68 billion (2024–2025) and projected to reach USD 1.80–2.20 billion by 2030, with a CAGR of 4.57–6.65%[1][4][16]. Discrepancies in growth rates stem from varying methodologies, but consensus highlights steady expansion due to:

  • Rising surgical volumes, particularly in outpatient and ambulatory settings (160+ ASCs performing spine surgeries in the U.S. alone)[1].
  • Technological advancements in vaporizers and monitoring systems, enabling precise dosing and faster recovery[7][16].
  • Emerging markets: Medical tourism in India/Thailand and healthcare investments in Latin America and MEA drive regional growth[4][16].

Key Market Drivers

1. Agent Efficacy and Safety

  • Sevoflurane dominates (rapid onset, minimal airway irritation) and is prioritized post-desflurane phaseouts in Europe[16]. Newer agents reduce postoperative agitation and nausea[15].
  • Environmental regulations: Shift toward agents like sevoflurane due to lower global warming potential vs. desflurane[16].

2. Surgical Innovations

  • Minimally invasive procedures and same-day surgeries demand fast-recovery anesthetics. Over 46% of Canadian cancer diagnoses in 2021 required surgical intervention, amplifying demand[10].
  • Cost-effectiveness: Inhalation anesthetics account for 5–13% of hospital drug budgets but reduce ICU stays and complications[3][13].

3. Strategic Collaborations

  • Acquisitions (e.g., Dechra Pharmaceuticals acquiring sevoflurane/isoflurane portfolios) and public-private partnerships enhance supply chain resilience[10][16].

Patent Landscape and Innovations

Drug Formulations

  • US4762856: Covers 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane compositions, foundational for modern halogenated agents[5].
  • CN1247741A: Emulsified IV inhalational anesthetics reduce pollution and enable controlled sedation[9].

Delivery Systems

  • Container Materials: Aluminum containers (US20110284418A1, WO2002022195A2) replace glass/plastic to prevent breakage and chemical degradation[8][11].
  • Smart Devices: Patent US20140166527A1 describes polyester/fluoropolymer containers compatible with vaporizers, improving portability[2].

Neuroprotective Applications

  • Isoflurane and xenon show NMDA/AMPA receptor antagonism, potentially mitigating cerebral ischemia damage[12].

Environmental and Regulatory Dynamics

  • Emission Reduction: Anesthetic recycling systems extract waste gases from ORs, aligning with EPA guidelines[13].
  • Patent Expirations: Generics entering the market pressure firms to innovate (e.g., Halocarbon’s sevoflurane patents)[10].
  • Regional Policies: EU phaseouts of high-GWP agents accelerate R&D in sustainable alternatives[16].

Future Outlook

North America retains dominance (52.8% share in 2024)[4], but Asia-Pacific grows fastest due to healthcare infrastructure investments. Innovations in neuroprotection and eco-friendly delivery systems will shape the next decade, with sevoflurane remaining central to clinical practice.

"The integration of smart technologies and digital monitoring systems has enabled healthcare providers to maintain better control over anesthetic depth and reduce complications."
Mordor Intelligence[1]

References

  1. https://www.mordorintelligence.com/industry-reports/inhalation-anesthetics-market
  2. https://patents.google.com/patent/US20140166527A1/en
  3. https://pubmed.ncbi.nlm.nih.gov/16554286/
  4. https://www.imarcgroup.com/inhalation-anesthesia-market
  5. https://www.drugpatentwatch.com/p/patent/4762856
  6. https://meshb.nlm.nih.gov/record/ui?ui=D018685
  7. https://marketresearch.biz/report/inhalation-anesthesia-market/
  8. https://patents.google.com/patent/US20110284418A1/en
  9. https://patents.google.com/patent/CN1247741A/en
  10. https://www.giiresearch.com/report/moi1441615-inhalation-anesthetics-market-share-analysis.html
  11. https://patents.google.com/patent/WO2002022195A2/en
  12. https://journals.sagepub.com/doi/10.1038/sj.jcbfm.9600410
  13. https://www.nextmsc.com/report/inhalation-anesthesia-market
  14. https://ispub.com/IJA/3/2/7433
  15. https://www.thebrainyinsights.com/report/inhalation-anesthetics-market-13164
  16. https://www.grandviewresearch.com/industry-analysis/inhalation-anesthesia-market
Last updated: 2025-03-24

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