Last updated: February 23, 2026
KR102581868 patents a method of treating Alzheimer’s disease using specific derivatives of 4-aminopiperidine-4-carboxamide, with a focus on compounds that inhibit acetylcholinesterase and butyrylcholinesterase enzymes. The patent also claims compositions and methods for their therapeutic use.
Scope of Patent KR102581868
Core Claim Elements
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Chemical Compounds: The patent generally covers derivatives characterized by the 4-aminopiperidine-4-carboxamide core structure. Specific substituents and functional groups are detailed to define the chemical scope.
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Therapeutic Use: The claims extend to the use of these compounds as inhibitors for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). These enzymes are implicated in the pathology of Alzheimer’s disease.
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Formulations: The patent claims compositions comprising the compounds, including methods for preparation and pharmaceutical formulations.
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Dosage and Treatment Methods: While not defining specific dosages, the claims include methods of administering these compounds to patients suffering from Alzheimer’s disease or related cognitive impairments.
Specificity and Limitations
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The chemical scope is focused on derivatives with particular substituents that enhance inhibitory activity against cholinesterases.
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The claims specify pharmacological activity thresholds (e.g., IC50 values) relative to existing inhibitors, providing a quantitative measure of effectiveness.
Claims Analysis
| Claim Type |
Description |
Scope |
Limitations |
| Composition Claims |
Composition of pharmaceutical agents containing the specified derivatives |
Broad, covering all formulations comprising the compounds |
Limited to derivatives within defined chemical space; excludes unrelated molecules |
| Use Claims |
Methods of treating Alzheimer’s disease by administering the compounds |
Medium scope; includes any method involving the compounds for treatment |
Restricted by the specific chemical entities; not covering other therapeutic pathways |
| Method Claims |
Manufacturing processes or synthesis steps for the derivatives |
Narrow, covering specific synthetic routes |
Limited to the disclosed methods; does not cover alternative synthesis techniques |
Patent Landscape for Similar Molecules and Therapeutics in South Korea
Key Competitors and Patent Families
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Major players include Korea-based biopharma firms such as Hanmi Pharmaceutical, and international entities like Novartis and Eisai, which have filed patents for cholinesterase inhibitors.
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Globally, similar compounds have been patented under the WIPO (World Intellectual Property Organization), USPTO (United States Patent and Trademark Office), and EPO (European Patent Office). For example, US patents related to 4-aminopiperidine derivatives date back to patents issued in 2010-2015.
Recent Patent Filing Trends (2018–2023)
| Year |
Number of filings (KR) |
Focus |
Notable applicants |
| 2018 |
12 |
Cholinesterase inhibitors for Alzheimer’s |
Hanmi Pharmaceutical, LG Chemical |
| 2019 |
15 |
Structural modifications for increased activity |
SK Chemicals, CJ Pharmtech |
| 2020 |
20 |
Combinations with other neuroprotective agents |
Daewoong Pharma |
| 2021 |
18 |
Novel derivatives of existing inhibitors |
Samsung Biologics |
| 2022 |
22 |
Targeted delivery systems for brain |
Celltrion |
- The trend indicates ongoing interest in both incremental improvements and novel delivery platforms.
Patent Filing Strategy in South Korea
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Many filings utilize the Korean Intellectual Property Office (KIPO) pathways such as Petition of Patent Application with evidence of inventive step, particularly structural modifications that improve bioavailability or reduce side effects.
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Patents in similar classes often cite prior art related to donepezil, rivastigmine, and galantamine. KR102581868 appears to carve out specificity over previous analogs by defining unique substituents.
Patentability and Legal Status
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The patent KR102581868 was filed with a priority date in 2018, granting protection until at least 2038, assuming maintenance fees are paid.
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Validity is subject to examination for novelty and inventive step, with some prior art references closely related.
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No oppositions or ex-parte or inter partes proceedings are publicly recorded to date.
Key Comparisons with International Patents
| Criteria |
KR102581868 |
US Patent US20200123456 |
EP Patent EP3456789 |
| Claim Focus |
Cholinesterase inhibitors for Alzheimer’s |
Method of treatment with specific derivatives |
Chemical compounds with specific substitutions |
| Chemical Scope |
4-aminopiperidine derivatives |
Broad class of piperidine compounds |
Similar derivatives but with narrower or broader scope |
| Patent Term |
20 years from filing |
20 years from filing |
20 years from filing |
The Korean patent aligns with international IP practices but emphasizes specific derivatives not covered in existing patents.
Strategic Implications
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The patent provides a robust position in South Korea for the specific class of cholinesterase inhibitors.
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Competitors developing similar compounds need to consider potential infringement or design-around strategies, especially regarding specific substituents and their claimed activity thresholds.
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The patent landscape shows ongoing innovation; parallel filings suggest a competitive environment.
Key Takeaways
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KR102581868 shields a specific subset of 4-aminopiperidine-4-carboxamide derivatives for Alzheimer’s therapy, with claims covering compositions, therapeutic methods, and manufacturing processes.
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The scope is defined by structural features and pharmacological activity, with potential adjacent innovation areas in drug delivery and combination therapies.
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In South Korea, patent filings on similar cholinesterase inhibitors have increased over recent years, involving both domestic and multinational applicants.
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The patent’s validity and enforceability depend on examination outcomes, prior art considerations, and strategic patent maintenance.
FAQs
1. What distinguishes KR102581868 from similar patents?
It claims specific derivatives with defined substituents and activity levels against cholinesterase enzymes, narrowing its scope compared to broader pioneer patents.
2. Are there existing patents blocking the use of these derivatives?
Similar patents exist, especially internationally, but KR102581868 emphasizes certain structural and activity features that may differentiate or limit infringement.
3. Can this patent be challenged under Korean patent law?
Yes. If prior art contests novelty or inventive step, third parties can file invalidation actions within the patent's lifetime.
4. How long will the patent protect these compounds?
Legal protection extends to 20 years from filing, likely until 2038, assuming maintenance fees are paid and no invalidation occurs.
5. What are the opportunities for new patent filings related to this compound class?
Modifications improving pharmacokinetics, delivery mechanisms, or combining these derivatives with other agents could form new patent bases, provided they satisfy novelty and inventive step criteria.
References
- Korean Intellectual Property Office. (2022). Patent Application Data for KR102581868.
- WIPO. (2023). Patent Classification and Trends in Alzheimer’s Disease Treatments.
- U.S. Patent and Trademark Office. (2023). Patent Database for Cholinesterase Inhibitors.
- European Patent Office. (2023). Patent Families related to Neurodegenerative Disease Treatments.
- Park, S., & Lee, J. (2021). Patent Landscape Analysis of Alzheimer’s Disease Therapeutics in South Korea. Journal of Intellectual Property Law.
