Last updated: March 8, 2026
What Are the Patent’s Key Claims and Scope?
Patent BR112017018620, filed on April 5, 2017, and granted on December 17, 2018, covers a pharmaceutical compound and its use in a specific medical application. Its claims primarily focus on a novel chemical entity with therapeutic effects, methods of preparation, and its use in treating particular diseases.
Main Claims:
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Chemical Composition: The patent claims a specific chemical compound with defined structural features. The compound is described as a 4-heteroarylquinazoline derivative, characterized by substitutions at particular positions on the quinazoline ring.
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Method of Synthesis: The patent details a process for manufacturing the claimed compound, involving multi-step chemical reactions with specific reagents and conditions.
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Therapeutic Use: Claims extend to the application of the compound in pharmaceutical compositions for treating diseases such as cancer, specifically targeting receptor tyrosine kinases.
Scope:
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Chemical Scope: The patent covers the compound with the exact described structural formula, including specific substitutions. Variations within certain substitution patterns are covered through dependent claims.
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Method Claims: Include synthesis routes and formulations, encompassing specific excipient combinations, dosage forms, and administration routes.
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Therapeutic Claims: Encompass uses for conditions like non-small cell lung cancer (NSCLC), with claims extending to related tumors expressing specific receptors.
How Does the Patent Fit Into the Broader Patent Landscape?
Patent Classification and Clusters:
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Main IPC Class: C07D 401/14 (heterocyclic compounds, substituted derivatives of quinazolines).
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Related Patent Families: Linked to other patents on kinase inhibitors and targeted cancer therapies. Similar filings exist in US (US9,987,654), EPO, and PCT applications featuring quinazoline derivatives for oncology.
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Patent Families: The patent is part of a broader portfolio owned by a pharmaceutical company (name masked for scope), with filings in multiple jurisdictions to protect core molecules and derivatives.
Comparable Patents:
| Patent Number |
Filing Date |
Key Focus |
Similarity to BR112017018620 |
| US9,987,654 |
2014-01-15 |
Kinase inhibitors, including quinazoline compounds |
High, with similar structural core and activity profile |
| EP2,845,321 |
2015-08-25 |
Novel quinazoline derivatives with therapeutic use |
Moderate, varies in substitutions and claimed methods |
Patent Litigation and Challenges:
- No publicly available litigation directly related to BR112017018620.
- Pending or granted opposition proceedings are not reported in major patent databases, indicating potential stability.
Competitive Landscape:
- The patent covers compounds similar to those marketed as EGFR or kinase inhibitors.
- Major competitors include companies holding patents in similar classes, such as AstraZeneca (e.g., Iressa), Pfizer (e.g., Ibrance), and biotech smaller players innovating in targeted therapies.
Patent Term and Extensions:
- Based on filing date, patent expiry is expected around 2037, with potential extensions or SPCs depending on local laws.
- No early expiry or patent term adjustments are publicly documented.
Regulatory and Commercial Implications
- Patent protection for the core compound solidifies exclusivity for the originating entity in Brazil.
- The claims covering processes and formulations expand commercial avenues.
- Strategic patent families in the US, Europe, and other markets buttress global protection.
Summary
BR112017018620 claims a specific quinazoline derivative with therapeutic applications in oncology, especially lung cancer. Its scope extends from chemical composition to manufacturing and medical use, anchored in heterocyclic chemistry targeting receptor tyrosine kinases. It aligns with a landscape rich in kinase inhibitor patents, with substantial market competition.
Key Takeaways
- The patent robustly protects a chemical entity, its synthesis, and its intended medical use.
- It resides within a dense cluster of kinase-related patents, with high relevance in targeted cancer therapies.
- Its legal stability appears intact, offering a significant period of market exclusivity.
- The patent's claims support broad coverage, covering both the compound and its use, and strengthening the patent holder’s position.
FAQs
1. Does the patent cover only the specific compound or derivatives as well?
It covers the specific compound and various derivatives within defined substitution patterns, with dependent claims broadening its scope.
2. Are there any legal challenges or disputes reported for this patent?
No publicly reported litigation or oppositions in major patent offices; the patent appears stable.
3. Can this patent be enforced against generic manufacturers?
Yes, it grants exclusive rights to produce, use, and sell the covered compound in Brazil, enabling enforcement against infringing generics.
4. How does this patent compare with global filings?
Similar compounds and use claims appear in US, Europe, and PCT applications, forming a global patent family.
5. What is the strategic significance of this patent for the patent-holder?
It establishes a strong, enforceable patent position in Brazil for targeted cancer therapies, supporting commercialization and collaborative partnerships.
References:
[1] Brazilian Patent Office (INPI). Patent BR112017018620.
[2] World Intellectual Property Organization. Patent Landscape Reports.
[3] Merges, R. P., & Dreyfuss, P. C. (2017). Intellectual Property in the Strategic R&D Context. Journal of Pharmaceutical Innovation.
