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Sincalide - Generic Drug Details

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What are the generic sources for sincalide and what is the scope of sincalide freedom to operate?

Sincalide is the generic ingredient in one branded drug marketed by Bracco and is included in one NDA. There is one patent protecting this compound. Additional information is available in the individual branded drug profile pages.

Sincalide has ten patent family members in eight countries.

There are three drug master file entries for sincalide. One supplier is listed for this compound.

Summary for sincalide

International Patents:	10
US Patents:	1
Tradenames:	1
Applicants:	1
NDAs:	1
Drug Master File Entries:	3
Suppliers / Packagers:	1
Bulk Api Vendors:	25
Clinical Trials:	3
Patent Applications:	477
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for sincalide
DailyMed Link:	sincalide at DailyMed

Pharmacology for sincalide

Ingredient-type	Cholecystokinin
Drug Class	Cholecystokinin Analog

Synonyms for sincalide

(3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-bis(2-(methylthio)ethyl)-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosane-1,2

(3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-amino-3-formamidopropanoic acid]-3-[4-(sulfooxy)phenyl]propanamido]-4-(methylsulfanyl)butanamido]acetamido}-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]-3-{[(1S

(3S)-3-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-hydroxy-4-oxobutanoyl]amino]-3-(4-sulfooxyphenyl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylsulfanyl

(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-(methylthio)-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]

(3S)-3-azanyl-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-4-oxidanyl-1,4-bis(oxidanylidene)butan-2-yl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]amino

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

[125I]CCK-8

1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein

126S323

25126-32-3

25345-10-2

89911-55-7

9038-72-6

91921-74-3

A817659

AKOS016340423

BDBM21147

C49H62N10O16S3

Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-

CAS-25126-32-3

CCK C-terminal octapeptide

CCK Octapeptide, sulfated

CCK-8

CCK-8 (sulphated)

CCK-8(SO3)

CHEBI:135946

CHEMBL1121

cholecystokinin 8

cholecystokinin C-terminal octapeptide

cholecystokinin fragment 26-33 amide (sulphated)

Cholecystokinin octapeptide

Cholecystokinin Octapeptide, sulfated

Cholecystokinin-8

Cholecystokinin-pancreozymin

CS-5963

D05845

D0I8AF

DB09142

DSSTox_CID_28543

DSSTox_GSID_48617

DSSTox_RID_82815

DTXSID7048617

EINECS 246-639-0

FT-0630515

GTPL864

H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Human CCK-8

HY-P0093

IZTQOLKUZKXIRV-YRVFCXMDSA-N

Kinevac

Kinevac (TN)

L-alpha-Aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide

L-Aspartyl-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide hydrogen sulfate (ester)

M03GIQ7Z6P

MFCD00079849

MolPort-006-124-517

NCGC00167273-01

NCGC00183278-01

NCGC00183363-01

O411

Pancreozymin

Pancreozymin C-terminal octapeptide

SC-47569

SCHEMBL122365

Sincalida

Sincalida [INN-Spanish]

Sincalide (Kinevac)

Sincalide (USP/INN)

Sincalide [USAN:USP:INN:BAN]

Sincalidum

Sincalidum [INN-Latin]

SQ 19844

SQ-19844

Syncalide

Tox21_112955

Tox21_113481

UNII-M03GIQ7Z6P

US Patents and Regulatory Information for sincalide

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Bracco	KINEVAC	sincalide	INJECTABLE;INJECTION	017697-001	Approved Prior to Jan 1, 1982		RX	Yes	Yes			Y

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Expired US Patents for sincalide

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Bracco	KINEVAC	sincalide	INJECTABLE;INJECTION	017697-001	Approved Prior to Jan 1, 1982

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International Patents for sincalide

Country	Document Number	Estimated Expiration
Germany	60336509
Austria	502647
World Intellectual Property Organization (WIPO)	2005027954
China	100374154