List of Excipients in Branded Drug ATHLETES FOOT

Company	Tradename	Ingredient	NDC	Excipient	Potential Generic Entry
Target Corporation	ATHLETES FOOT	terbinafin hydrochloride	11673-401	BENZYL ALCOHOL
Target Corporation	ATHLETES FOOT	terbinafin hydrochloride	11673-401	CETYL ALCOHOL
Target Corporation	ATHLETES FOOT	terbinafin hydrochloride	11673-401	CETYL PALMITATE
Target Corporation	ATHLETES FOOT	terbinafin hydrochloride	11673-401	ISOPROPYL MYRISTATE
Target Corporation	ATHLETES FOOT	terbinafin hydrochloride	11673-401	POLYSORBATE 60
Target Corporation	ATHLETES FOOT	terbinafin hydrochloride	11673-401	SODIUM HYDROXIDE
Target Corporation	ATHLETES FOOT	terbinafin hydrochloride	11673-401	SORBITAN MONOSTEARATE

Generic Drugs Containing ATHLETES FOOT

Company	Ingredient	NDC	Excipient
Walgreen Company	butenafine hydrochloride	0363-2100	BENZYL ALCOHOL
Walgreen Company	butenafine hydrochloride	0363-2100	CETETH-23
Walgreen Company	butenafine hydrochloride	0363-2100	CETYL ALCOHOL
Walgreen Company	butenafine hydrochloride	0363-2100	GLYCERIN
Walgreen Company	butenafine hydrochloride	0363-2100	GLYCERYL STEARATE SE
Walgreen Company	butenafine hydrochloride	0363-2100	PROPYLENE GLYCOL DICAPRYLATE
Walgreen Company	butenafine hydrochloride	0363-2100	SODIUM BENZOATE

What are the Most Frequently-Used Excipients in ATHLETES FOOT?

# Of NDCs	Excipient
16	BENZYL ALCOHOL
7	CETETH-23
16	CETYL ALCOHOL
9	CETYL PALMITATE
7	GLYCERIN
6	GLYCERYL STEARATE SE
9	ISOPROPYL MYRISTATE

Excipient Strategy and Commercial Opportunities for Athletes Foot Drugs

Last updated: March 3, 2026

What role do excipients play in athlete's foot medications?

Excipients in athlete's foot formulations serve as inactive agents that enhance stability, improve bioavailability, and facilitate manufacturing. They include adhesives, preservatives, solvents, stabilizers, and pH adjusters. Common excipients include propylene glycol, polyethylene glycol, ethanol, and dimethyl sulfoxide (DMSO).

How do excipient choices impact drug delivery and efficacy?

Excipients influence drug skin penetration, stability, and patient tolerability. For topical formulations like creams and sprays, penetration enhancers such as propylene glycol and DMSO increase the drug's absorption into affected skin layers. Preservatives like parabens improve shelf life. The choice of excipient affects onset of action and duration of efficacy.

What are key considerations in developing excipient strategies for athlete's foot medications?

• Skin compatibility: Minimize irritation, especially for sensitive skin.
• Penetration enhancement: Use agents that facilitate active ingredient absorption without causing toxicity.
• Stability: Ensure excipients do not react adversely with active ingredients or degrade over shelf life.
• Regulatory compliance: Select excipients approved by the FDA, EMA, or other authorities for topical use.

Which excipients are prevalent in marketed athlete's foot products?

Excipient Type	Examples	Function	Market Presence
Penetration enhancers	Propylene glycol, DMSO	Improve drug absorption	Widely used, e.g., Lotrimin AF
Preservatives	Methylparaben, Propylparaben	Extend shelf life	Standard in OTC creams
Emollients	Petrolatum, Mineral oil	Moisturize skin	Common in barrier creams
Solvents	Ethanol, Isopropyl alcohol	Dissolve active ingredients	Used in sprays and solutions

What are the commercial opportunities around excipient innovation?

1. Enhanced efficacy formulations: Developing new penetration enhancers can reduce treatment duration and improve cure rates.
2. Reduced irritation products: Creating excipients that minimize skin irritation opens opportunities in sensitive skin segments.
3. Shelf-stable products: Formulating with novel preservatives or stabilizers increases shelf life and appeal.
4. Combination products: Incorporating multiple actives with optimized excipients addresses resistant strains and recurrence.

How do regulatory trends inform excipient strategy?

Regulatory bodies increasingly scrutinize excipient safety, especially in topical drugs intended for prolonged use. Preference shifts toward natural or biocompatible excipients are evident. Companies investing in biodegradable, non-toxic excipients can differentiate their products and anticipate faster approvals.

What are the market dynamics for athlete's foot medications?

The global topical antifungal market was valued at approximately USD 2 billion in 2022 and is growing at a CAGR of 4% (Grand View Research). Dominant players include Johnson & Johnson, Novartis, and Bayer. OTC products account for 85% of sales, with cream formulations leading. There's steady innovation in formulation, with a focus on rapid onset and minimal irritation, aligning with excipient strategy evolution.

Key Takeaways

• Excipients influence drug stability, absorption, and patient experience.
• Penetration enhancers like propylene glycol are central in topical athlete's foot medications.
• Innovation in excipients can improve efficacy, tolerability, and shelf stability.
• Regulatory trends favor natural, non-toxic excipients, presenting market differentiation.
• The market's growth supports opportunities for formulations with improved excipient profiles.

FAQs

1. Which excipients are safest for sensitive skin in athlete's foot products?
   Natural oils, certain biocompatible preservatives (e.g., benzyl alcohol), and non-irritating penetration enhancers like glycerin.

2. Can novel excipients improve the treatment duration for athlete's foot?
   Yes, by enhancing drug penetration and retention, novel excipients can reduce application frequency and therapy length.

3. What regulatory hurdles exist for new excipients in topical antifungals?
   Regulatory approval requires demonstration of safety and efficacy, with extensive testing for skin irritation or sensitization.

4. Are there gaps in excipient options for athlete's foot medications?
   Yes, especially in developing non-irritating, biodegradable penetration enhancers that are also highly effective.

5. How does excipient choice impact product differentiation?
   It affects onset of action, tolerability, stability, and shelf life, enabling brands to position products for specific consumer needs.

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References

[1] Grand View Research. (2022). Topical Antifungal Market Size, Share & Trends Analysis. [2] U.S. Food and Drug Administration. (2021). Guidance for Industry: Topical Drug Products. [3] EMA. (2020). Guideline on the use of excipients in topical and cutaneous preparations.