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Last Updated: December 12, 2025

List of Excipients in API bupivacaine

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Excipients in NDA-approved (novel) drugs containing bupivacaine

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Company	Tradename	Ingredient	NDC	Excipient	Potential Generic Entry
Renaissance Lakewood LLC	POSIMIR	bupivacaine	49396-6601	BENZYL ALCOHOL
Renaissance Lakewood LLC	POSIMIR	bupivacaine	49396-6601	SUCROSE ACETATE ISOBUTYRATE
INNOCOLL PHARMACEUTICALS	POSIMIR	bupivacaine	51715-660	BENZYL ALCOHOL
>Company	>Tradename	>Ingredient	>NDC	>Excipient	>Potential Generic Entry

Excipients in ANDA-approved (generic) drugs containing bupivacaine

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Company	Ingredient	NDC	Excipient
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581	HYDROCHLORIC ACID
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581	METHYLPARABEN
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581	SODIUM CHLORIDE
>Company	>Ingredient	>NDC	>Excipient

Detailed excipient profiles for bupivacaine

Excipient focus: ANHYDROUS DEXTROSE

bupivacaine drug variants containing ANHYDROUS DEXTROSE

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Company	Ingredient	NDC
B Braun Medical Inc	bupivacaine hydrochloride with dextrose	0264-9379
Hospira Inc	bupivacaine hydrochloride in dextrose	0409-1761
Hospira Inc	bupivacaine hydrochloride in dextrose	0409-3613
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing ANHYDROUS DEXTROSE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: ASCORBIC ACID

bupivacaine drug variants containing ASCORBIC ACID

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Company	Ingredient	NDC
Hospira Inc	bupivacaine hydrochloride and epinephrine	0409-5738
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-0557
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-9011
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing ASCORBIC ACID

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: BENZYL ALCOHOL

bupivacaine drug variants containing BENZYL ALCOHOL

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing BENZYL ALCOHOL

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Company	Ingredient	NDC
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci and epinephrine	51662-1399
>Company	>Ingredient	>NDC

Excipient focus: CITRIC ACID MONOHYDRATE

bupivacaine drug variants containing CITRIC ACID MONOHYDRATE

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Company	Ingredient	NDC
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci and epinephrine	51662-1399
Fresenius Kabi USA LLC	bupivacaine hydrochloride and epinephrine bitartrate	63323-462
Fresenius Kabi USA LLC	bupivacaine hydrochloride and epinephrine bitartrate	63323-468
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing CITRIC ACID MONOHYDRATE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: DETOSU/TRIETHYLENE GLYCOL/TRIETHYLENE GLYCOL POLYGLYCOLIDE COPOLYMER

bupivacaine drug variants containing DETOSU/TRIETHYLENE GLYCOL/TRIETHYLENE GLYCOL POLYGLYCOLIDE COPOLYMER

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Company	Ingredient	NDC
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing DETOSU/TRIETHYLENE GLYCOL/TRIETHYLENE GLYCOL POLYGLYCOLIDE COPOLYMER

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
>Company	>Ingredient	>NDC

Excipient focus: DEXTROSE

bupivacaine drug variants containing DEXTROSE

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Company	Ingredient	NDC
Brookfield Pharmaceuticals LLC	bupivacaine hydrochloride	71351-022
Huons Co Ltd	bupivacaine hydrochloride	73293-0002
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing DEXTROSE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: DIMETHYL SULFOXIDE

bupivacaine drug variants containing DIMETHYL SULFOXIDE

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Company	Ingredient	NDC
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing DIMETHYL SULFOXIDE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
>Company	>Ingredient	>NDC

Excipient focus: EDETATE CALCIUM DISODIUM

bupivacaine drug variants containing EDETATE CALCIUM DISODIUM

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Company	Ingredient	NDC
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-0557
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-9011
Henry Schein Inc	bupivacaine hydrochloride and epinephrine bitartrate	0404-9908
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing EDETATE CALCIUM DISODIUM

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: HYDROCHLORIC ACID

bupivacaine drug variants containing HYDROCHLORIC ACID

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Company	Ingredient	NDC
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci and epinephrine	51662-1399
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hcl	51662-1592
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing HYDROCHLORIC ACID

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: MALEIC ACID

bupivacaine drug variants containing MALEIC ACID

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Company	Ingredient	NDC
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing MALEIC ACID

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
>Company	>Ingredient	>NDC

Excipient focus: METHYLPARABEN

bupivacaine drug variants containing METHYLPARABEN

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Company	Ingredient	NDC
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci and epinephrine	51662-1399
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hcl	51662-1592
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing METHYLPARABEN

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: MONOTHIOGLYCEROL

bupivacaine drug variants containing MONOTHIOGLYCEROL

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Company	Ingredient	NDC
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-0557
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-9011
Henry Schein Inc	bupivacaine hydrochloride and epinephrine bitartrate	0404-9908
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing MONOTHIOGLYCEROL

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: NITROGEN

bupivacaine drug variants containing NITROGEN

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Company	Ingredient	NDC
Brookfield Pharmaceuticals LLC	bupivacaine hydrochloride	71351-022
Huons Co Ltd	bupivacaine hydrochloride	73293-0002
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing NITROGEN

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: SODIUM CHLORIDE

bupivacaine drug variants containing SODIUM CHLORIDE

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Company	Ingredient	NDC
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci and epinephrine	51662-1399
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hcl	51662-1592
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing SODIUM CHLORIDE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: SODIUM HYDROXIDE

bupivacaine drug variants containing SODIUM HYDROXIDE

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Company	Ingredient	NDC
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci and epinephrine	51662-1399
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hcl	51662-1592
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing SODIUM HYDROXIDE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: SODIUM LACTATE

bupivacaine drug variants containing SODIUM LACTATE

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Company	Ingredient	NDC
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-0557
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-9011
Henry Schein Inc	bupivacaine hydrochloride and epinephrine bitartrate	0404-9908
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing SODIUM LACTATE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: SODIUM METABISULFITE

bupivacaine drug variants containing SODIUM METABISULFITE

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Company	Ingredient	NDC
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci and epinephrine	51662-1399
Hospira Inc	bupivacaine hydrochloride and epinephrine	0409-5738
Septodont Inc	bupivacaine hydrochloride and epinephrine bitartrate	0362-0557
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing SODIUM METABISULFITE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

Excipient focus: SUCROSE ACETATE ISOBUTYRATE

bupivacaine drug variants containing SUCROSE ACETATE ISOBUTYRATE

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing SUCROSE ACETATE ISOBUTYRATE

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Company	Ingredient	NDC
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci and epinephrine	51662-1399
>Company	>Ingredient	>NDC

Excipient focus: TRIACETIN

bupivacaine drug variants containing TRIACETIN

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Company	Ingredient	NDC
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing TRIACETIN

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
>Company	>Ingredient	>NDC

Excipient focus: WATER

bupivacaine drug variants containing WATER

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Company	Ingredient	NDC
HF Acquisition Co LLC DBA HealthFirst	bupivacaine hci	51662-1581
Hikma Pharmaceuticals USA Inc	bupivacaine hydrochloride	0143-9328
Hikma Pharmaceuticals USA Inc	bupivacaine hydrochloride	0143-9330
>Company	>Ingredient	>NDC

bupivacaine drug variants not containing WATER

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Company	Ingredient	NDC
Renaissance Lakewood LLC	bupivacaine	49396-6601
INNOCOLL PHARMACEUTICALS	bupivacaine	51715-660
Heron Therapeutics Inc	bupivacaine and meloxicam	47426-301
>Company	>Ingredient	>NDC

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