CLINICAL TRIALS PROFILE FOR L-LEUCOVORIN

Clinical Trials for l-leucovorin

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00002002 ↗	A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome	Completed	Lederle Laboratories	N/A	The primary objective of the study is to evaluate the effectiveness of l-leucovorin in preventing toxicity from high dose trimethoprim / sulfamethoxazole (TMP / SMX) used as a therapy for Pneumocystis carinii pneumonia (PCP) in patients with AIDS.
NCT00005586 ↗	Leucovorin and Fluorouracil Compared With Observation in Treating Patients With Colorectal Cancer That Has Been Surgically Removed	Completed	Institute of Cancer Research, United Kingdom	Phase 3	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether chemotherapy is more effective than observation in patients who have had surgery to remove colorectal cancer. PURPOSE: This randomized phase III trial is studying leucovorin and fluorouracil to see how well they work compared to observation in treating patients with colorectal cancer that has been surgically removed.
NCT00046995 ↗	Combination Chemotherapy in Treating Patients With Colon Cancer	Unknown status	Groupe Regional d'Etudes du Cancer Colorectal	Phase 3	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which schedule of chemotherapy is most effective in treating colon cancer. PURPOSE: Randomized phase III trial to compare different schedules of chemotherapy using carboplatin with fluorouracil and leucovorin in treating patients who have stage IIB or stage III colon cancer.
NCT00190515 ↗	A Trial Comparing Adjuvant Oral UFT/LV to 5-FU/l-LV in Stage III Colorectal Cancer (JCOG-0205-MF)	Completed	Ministry of Health, Labour and Welfare, Japan	Phase 3	To evaluate the clinical effectiveness of oral UFT/LV comparing 5-FU/l-LV as adjuvant therapy for stage III colorectal cancer.
NCT00190515 ↗	A Trial Comparing Adjuvant Oral UFT/LV to 5-FU/l-LV in Stage III Colorectal Cancer (JCOG-0205-MF)	Completed	Haruhiko Fukuda	Phase 3	To evaluate the clinical effectiveness of oral UFT/LV comparing 5-FU/l-LV as adjuvant therapy for stage III colorectal cancer.
NCT00209625 ↗	Phase I / II Study of Irinotecan (CPT-11) Combined With l-Leucovorin (l-LV) and 5-FU in Patients With Advanced Colorectal Cancer	Completed	Hokkaido Gastrointestinal Cancer Study Group	Phase 1/Phase 2	We performed a phase I/II study of CPT-11/5FU/l-LV in advanced colorectal cancer, to determine the optimal dose of CPT-11 and to estimate the safety and efficacy of this regimen
NCT00209703 ↗	Feasibility Study of mFOLFOX6 in Patients With Advanced Colorectal Cancer	Terminated	Hokkaido Gastrointestinal Cancer Study Group	Phase 2	We performed a feasibility study of mFOLFOX6 in advanced colorectal cancer in Japan and to estimate the safety and efficacy of this regimen.

Clinical Trial Conditions for l-leucovorin

Condition Name

Condition Name for
Intervention	Trials
Colorectal Cancer	6
Metastatic Colorectal Cancer	5
Language Disorders	2
Autism Spectrum Disorder	2

Condition MeSH

Condition MeSH for
Intervention	Trials
Colorectal Neoplasms	17
Autistic Disorder	2
Adenocarcinoma	2
Autism Spectrum Disorder	2

Clinical Trial Locations for l-leucovorin

Trials by Country

Trials by Country for
Location	Trials
United States	57
Japan	39
Italy	6
Canada	4
United Kingdom	3

Trials by US State

Trials by US State for
Location	Trials
New York	4
California	3
Arizona	3
South Carolina	2
Ohio	2

Clinical Trial Progress for l-leucovorin

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase	Trials
Phase 3	8
Phase 2	10
Phase 1/Phase 2	3

Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase	Trials
Completed	9
Active, not recruiting	5
Recruiting	4

Clinical Trial Sponsors for l-leucovorin

Sponsor Name

Sponsor Name for
Sponsor	Trials
Gruppo Oncologico del Nord-Ovest	6
Hokkaido Gastrointestinal Cancer Study Group	3
Pfizer	3

Sponsor Type

Sponsor Type for
Sponsor	Trials
Other	33
Industry	7
U.S. Fed	2