A Phase II, Study To Evaluate The Efficacy And Safety Of PH-797804 In Adults With Moderate To Severe Chronic Obstructive Pulmonary Disease (COPD).
PH-797804 is a potent ant-inflammatory drug that may reduce the inflammation that is
associated with COPD. PH-797804 will be dosed to patients with COPD to evaluate its
potential safety and efficacy profile in COPD.
PH-797804 Versus Placebo For The Treatment Of Neuropathic Pain Associated With Post-Herpetic Neuralgia
This is a proof-of-concept study to determine if PH-797804 reduces neuropathic pain
associated with post-herpetic neuralgia. Suitable patients will be randomized to receive
either PH-797804 or placebo for 4 weeks, during which time they will also record their pain
symptoms using various pain scales.
A Study To Evaluate The Safety And Pharmacokinetic Profile Of A P38 Inhibitor (PH-797804) In Subjects With Rheumatoid Arthritis Who Are Also Taking Methotrexate
The hypothesis of this study is that the p38 inhibitor (PH-797804) will be safe and well
tolerated in subjects with rheumatoid arthritis who are taking methotrexate and will not
effect the blood levels of methotrexate.
Clinical Trial to Examine the Pain Relief of PH-797804 Alone Or With Naproxen in Subjects With Osteoarthritis of the Knee
PH-797804 is a potent inhibitor of inflammatory mediators that have a potential role in pain
signalling following nerve injury and inflammation. Blocking such mediators may potentially
have a therapeutic benefit by reducing pain.
A Study In Healthy Volunteers To Assess The Safety, Tolerability, And Relative Oral Bioavailability Of Three Formulations Of PH-797804
There is no difference in the rate and extent of absorption of the material sparing tablet
(MST), the Phase2b/3 formulation (P2b/3) with sodium lauryl sulphate (SLS) and the p2b/3
formulation without SLS.
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