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Last Updated: May 4, 2024

CLINICAL TRIALS PROFILE FOR LOXO-305


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Clinical Trials for LOXO-305

Trial ID Title Status Sponsor Phase Summary
NCT03740529 ↗ A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL Recruiting Loxo Oncology, Inc. Phase 1/Phase 2 This is an open-label, multi-center Phase 1/2 study of oral LOXO-305 in patients with CLL/SLL and NHL who have failed or are intolerant to standard of care.
NCT04662255 ↗ Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) Recruiting Loxo Oncology, Inc. Phase 3 This is a study for participants with a type of blood cancer called mantle cell lymphoma (MCL). The main purpose is to compare LOXO-305 to other drugs that work in a similar way that have already been approved by the United States Food and Drug Administration (US FDA). Participation could last up to two years, and possibly longer, if the disease does not progress.
NCT04666038 ↗ Study of LOXO-305 Versus Investigator's Choice (IdelaR or BR) in Patients With CLL or SLL Recruiting Loxo Oncology, Inc. Phase 3 This is a study for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL) who have previously received treatment with at least a BTK inhibitor. The main purpose is to compare LOXO-305 to idelalisib plus rituximab or bendamustine plus rituximab. Participation could last up to four years, and possibly longer, if the disease does not progress.
NCT04849416 ↗ A Study of LOXO-305 in Chinese Participants With Blood Cancer (Including Lymphoma and Chronic Leukemia) Recruiting Eli Lilly and Company Phase 2 A study of the safety, side effects, and effectiveness of LOXO-305 in Chinese adults with lymphoma or chronic leukemia who have already had standard of care treatment. Participation could last up to four years.
NCT04965493 ↗ A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Recruiting Loxo Oncology, Inc. Phase 3 The purpose of this study is to compare the efficacy and safety of fixed duration pirtobruitinib (LOXO-305) with VR (Arm A) compared to VR alone (Arm B) in patients with CLL/SLL who have been previously treated with at least one prior line of therapy. Participation could last up to five years.
>Trial ID >Title >Status >Phase >Summary

Clinical Trial Conditions for LOXO-305

Condition Name

Condition Name for
Intervention Trials
Chronic Lymphocytic Leukemia 7
Small Lymphocytic Lymphoma 7
Lymphoma, Mantle-Cell 3
Mantle Cell Lymphoma 3
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Condition MeSH

Condition MeSH for
Intervention Trials
Lymphoma 11
Leukemia, Lymphoid 10
Leukemia, Lymphocytic, Chronic, B-Cell 10
Leukemia 9
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Clinical Trial Locations for LOXO-305

Trials by Country

Trials by Country for
Location Trials
United States 68
Japan 25
China 18
United Kingdom 9
France 8
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Trials by US State

Trials by US State for
Location Trials
Florida 7
Texas 6
Louisiana 3
Tennessee 3
Ohio 3
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Clinical Trial Progress for LOXO-305

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase Trials
Phase 3 5
Phase 2 7
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase Trials
Not yet recruiting 7
Recruiting 7
Completed 2
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Clinical Trial Sponsors for LOXO-305

Sponsor Name

Sponsor Name for
Sponsor Trials
Loxo Oncology, Inc. 10
Eli Lilly and Company 3
M.D. Anderson Cancer Center 3
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Sponsor Type

Sponsor Type for
Sponsor Trials
Industry 13
Other 8
NIH 1
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