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Last Updated: May 2, 2024

CLINICAL TRIALS PROFILE FOR DEPATUXIZUMAB MAFODOTIN


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Clinical Trials for Depatuxizumab mafodotin

Trial ID Title Status Sponsor Phase Summary
NCT01800695 ↗ Evaluating the Safety and Pharmacokinetics of ABT-414 for Subjects With Glioblastoma Multiforme Completed AbbVie Phase 1 This study is evaluating the safety and pharmacokinetics of ABT-414 in subjects with glioblastoma multiforme.
NCT02343406 ↗ Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas Completed European Organisation for Research and Treatment of Cancer - EORTC Phase 2 This study was conducted to evaluate the efficacy and safety of depatuxizumab mafodotin (ABT-414) alone or with temozolomide versus temozolomide or lomustine alone in adult participants with recurrent glioblastoma. The study also included a substudy to evaluate safety, tolerability and pharmacokinetics of ABT-414 in a pediatric population.
NCT02343406 ↗ Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas Completed AbbVie Phase 2 This study was conducted to evaluate the efficacy and safety of depatuxizumab mafodotin (ABT-414) alone or with temozolomide versus temozolomide or lomustine alone in adult participants with recurrent glioblastoma. The study also included a substudy to evaluate safety, tolerability and pharmacokinetics of ABT-414 in a pediatric population.
>Trial ID >Title >Status >Phase >Summary

Clinical Trial Conditions for Depatuxizumab mafodotin

Condition Name

Condition Name for
Intervention Trials
Glioblastoma Multiforme 3
Glioblastoma 1
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Condition MeSH

Condition MeSH for
Intervention Trials
Glioblastoma 3
Glioma 1
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Clinical Trial Locations for Depatuxizumab mafodotin

Trials by Country

Trials by Country for
Location Trials
United States 24
Australia 10
Germany 6
France 6
Belgium 5
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Trials by US State

Trials by US State for
Location Trials
New York 3
Illinois 3
California 3
Texas 3
Massachusetts 2
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Clinical Trial Progress for Depatuxizumab mafodotin

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase Trials
Phase 3 1
Phase 2 1
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase Trials
Completed 2
Terminated 1
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Clinical Trial Sponsors for Depatuxizumab mafodotin

Sponsor Name

Sponsor Name for
Sponsor Trials
AbbVie 3
European Organisation for Research and Treatment of Cancer - EORTC 1
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Sponsor Type

Sponsor Type for
Sponsor Trials
Industry 3
Other 1
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