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Last Updated: September 22, 2020

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CLINICAL TRIALS PROFILE FOR AZD8871

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Clinical Trials for AZD8871

Trial ID Title Status Sponsor Phase Summary
NCT02573155 Two-part Safety, Tolerability, Pharmacodynamic and -Kinetic Study of Inhaled AZD8871 in Asthmatic and COPD Subjects Completed AstraZeneca Phase 1 This is a phase I, randomised, placebo-controlled 2-part study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8871 delivered by inhalation, in asthmatic and chronic obstructive pulmonary disease (COPD) subjects.
NCT02814656 Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Subjects Completed Parexel Phase 1 AZD8871 is a new chemical entity possessing long-acting effect in a single molecule which presents a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]). The therapeutic goal for AZD8871 is a treatment with greater efficacy than single mechanism bronchodilators, with an equivalent or superior safety and tolerability profile. The primary purpose of this study is to check the safety and tolerability of AZD8871 at steady state. A multiple ascending dose (MAD) design has been selected for this study following the first time in man (FTIM), single ascending dose (SAD) study. Three dose levels will be tested in an ascending manner. The first dose to be administered will be 300 μg and the 2 subsequent doses will be decided based on safety, tolerability and pharmacokinetic (PK) data generated in the previous dose. The aim of this study is to also enable further investigations in healthy subjects to evaluate and develop AZD8871 as a dual action bronchodilator with an acceptable side-effect profile compared to other inhaled bronchodilators on the market as a treatment for COPD and asthma.
NCT02814656 Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Subjects Completed AstraZeneca Phase 1 AZD8871 is a new chemical entity possessing long-acting effect in a single molecule which presents a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]). The therapeutic goal for AZD8871 is a treatment with greater efficacy than single mechanism bronchodilators, with an equivalent or superior safety and tolerability profile. The primary purpose of this study is to check the safety and tolerability of AZD8871 at steady state. A multiple ascending dose (MAD) design has been selected for this study following the first time in man (FTIM), single ascending dose (SAD) study. Three dose levels will be tested in an ascending manner. The first dose to be administered will be 300 μg and the 2 subsequent doses will be decided based on safety, tolerability and pharmacokinetic (PK) data generated in the previous dose. The aim of this study is to also enable further investigations in healthy subjects to evaluate and develop AZD8871 as a dual action bronchodilator with an acceptable side-effect profile compared to other inhaled bronchodilators on the market as a treatment for COPD and asthma.
NCT02971293 Efficacy, Pharmacokinetics (PK), Safety and Tolerability Study of Inhaled AZD8871 Recruiting Parexel Phase 2 This is a study to evaluate the effects of AZD8871 in patients with COPD. Adult male or female patients with moderate to severe COPD, who agree to be in this study, will receive 3 treatments, i.e. 2 different doses of AZD8871 and placebo (dummy medication containing no drug) at once a day for 2 weeks, in a random order. To make the comparison between AZD8871 and placebo as fair as possible, this study is "double blinded." This means that neither patient nor the study doctor will know in which order the 3 treatments will be given. This study will include patients who are between 40 and 80 years of age. In total there will be 42 patients participating in this study at two study centers in the United Kingdom and Germany. The study will have a total of 12 visits for each patient spanning for a period of 4 to 6 months. The study is anticipated to run for approximately 8 months and should not exceed 10 months.
>Trial ID >Title >Status >Phase >Summary

Clinical Trial Conditions for AZD8871

Condition Name

Condition Name for
Intervention Trials
Chronic Obstructive Pulmonary Disease 2
Asthma (Part 1) 1
COPD (Part 2) 1
Chronic Obstructive Pulmonary Disease (COPD) 1
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Condition MeSH

Condition MeSH for
Intervention Trials
Pulmonary Disease, Chronic Obstructive 5
Lung Diseases, Obstructive 4
Lung Diseases 4
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Clinical Trial Locations for AZD8871

Trials by Country

Trials by Country for
Location Trials
United Kingdom 5
Germany 2
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Clinical Trial Progress for AZD8871

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase Trials
Phase 2 2
Phase 1 3
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Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase Trials
Completed 2
Recruiting 2
Not yet recruiting 1
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Clinical Trial Sponsors for AZD8871

Sponsor Name

Sponsor Name for
Sponsor Trials
AstraZeneca 5
Parexel 4
The Doctors Laboratory 1
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Sponsor Type

Sponsor Type for
Sponsor Trials
Industry 10
Other 2
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