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Last Updated: August 14, 2020

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CLINICAL TRIALS PROFILE FOR AZD2014

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Clinical Trials for AZD2014

Trial ID Title Status Sponsor Phase Summary
NCT01026402 Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Efficacy of AZD2014 Completed AstraZeneca Phase 1 The main purpose of the study is to establish a safe dose of the drug by providing information on any potential side effects this drug may cause and collecting data about how a patient's cancer responds to the drug. The study will also assess the blood levels and action of AZD2014 in the body over a period of time and will indicate whether the drug has an effect on the types of cancer the patients have.
NCT01597388 AZD2014 and Fulvestrant in Patients With ER+ Advanced Metastatic Breast Cancer Active, not recruiting AstraZeneca Phase 1 The purpose of this study is to assess safety and tolerability of AZD2014 when given in combination with Fulvestrant.
NCT01793636 A Study Comparing AZD2014 vs Everolimus in Patients With Metastatic Renal Cancer Terminated AstraZeneca Phase 2 When kidney cancer spreads beyond the kidney, it is known as metastatic kidney cancer. This is very difficult to treat and almost all patients will die of their disease within 2 years of the diagnosis. Sunitinib and other related drugs (e.g. pazopanib) have become standard therapy for untreated patients with metastatic kidney cancer. They target a growth factor known as VEGF which is important in treating kidney cancer. Although the results with this drug are impressive, patients develop resistance to the drug and stop therapy. It is currently standard practice is to give everolimus when resistance to sunitinib occurs; this is associated with clear clinical benefit. However the average time to cancer regrowth with everolimus is only 5 months. It is thought this might be because, everolimus only partially inhibits its target (TORC 1 and TORC 2). Therefore further improvement in treating patients is required. AZD2014 is a promising new drug which does inhibit both TORC 1 and TORC 2 and is therefore worthy of investigation in renal cancer as it theoretically could may have advantages over everolimus. Therefore study compares AZD2014 to everolimus in the setting where everolimus is used as standard of care. (e.g. in patients who have failed drug like sunitinib). The study is a randomised trial allowing us to quantify the benefit and potential for further development of AZD2014. Repeat Xrays (CT scans) will be used to assess if the new drug delays tumour growth. Patients will be closely followed up in clinic to ensure safety. A maximum of 122 patients will be recruited into this multi centre national trial. The primary goal of the study is to investigate if AZ2014 delays the time for cancer regrowth (time to progression) compared to everolimus.
NCT01793636 A Study Comparing AZD2014 vs Everolimus in Patients With Metastatic Renal Cancer Terminated Cancer Research UK Phase 2 When kidney cancer spreads beyond the kidney, it is known as metastatic kidney cancer. This is very difficult to treat and almost all patients will die of their disease within 2 years of the diagnosis. Sunitinib and other related drugs (e.g. pazopanib) have become standard therapy for untreated patients with metastatic kidney cancer. They target a growth factor known as VEGF which is important in treating kidney cancer. Although the results with this drug are impressive, patients develop resistance to the drug and stop therapy. It is currently standard practice is to give everolimus when resistance to sunitinib occurs; this is associated with clear clinical benefit. However the average time to cancer regrowth with everolimus is only 5 months. It is thought this might be because, everolimus only partially inhibits its target (TORC 1 and TORC 2). Therefore further improvement in treating patients is required. AZD2014 is a promising new drug which does inhibit both TORC 1 and TORC 2 and is therefore worthy of investigation in renal cancer as it theoretically could may have advantages over everolimus. Therefore study compares AZD2014 to everolimus in the setting where everolimus is used as standard of care. (e.g. in patients who have failed drug like sunitinib). The study is a randomised trial allowing us to quantify the benefit and potential for further development of AZD2014. Repeat Xrays (CT scans) will be used to assess if the new drug delays tumour growth. Patients will be closely followed up in clinic to ensure safety. A maximum of 122 patients will be recruited into this multi centre national trial. The primary goal of the study is to investigate if AZ2014 delays the time for cancer regrowth (time to progression) compared to everolimus.
>Trial ID >Title >Status >Phase >Summary

Clinical Trial Conditions for AZD2014

Condition Name

Condition Name for
Intervention Trials
Solid Tumor 2
Meningioma 2
Advanced Solid Malignancies 2
Advanced Castrate-resistant Prostate Cancer (CRPC) 1
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Condition MeSH

Condition MeSH for
Intervention Trials
Lung Neoplasms 6
Breast Neoplasms 6
Carcinoma, Non-Small-Cell Lung 4
Neoplasms 3
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Clinical Trial Locations for AZD2014

Trials by Country

Trials by Country for
Location Trials
United States 35
United Kingdom 16
Korea, Republic of 5
Canada 4
France 4
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Trials by US State

Trials by US State for
Location Trials
Massachusetts 5
Tennessee 4
Michigan 4
South Carolina 2
Oklahoma 2
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Clinical Trial Progress for AZD2014

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase Trials
Phase 2 16
Phase 1/Phase 2 7
Phase 1 9
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Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase Trials
Recruiting 20
Not yet recruiting 4
Active, not recruiting 3
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Clinical Trial Sponsors for AZD2014

Sponsor Name

Sponsor Name for
Sponsor Trials
AstraZeneca 23
Samsung Medical Center 6
Cancer Research UK 4
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Sponsor Type

Sponsor Type for
Sponsor Trials
Other 36
Industry 26
NIH 2
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