Drug Price Trends for NDC 76282-0782

Average Pharmacy Cost for 76282-0782

Drug Name	NDC	Price/Unit ($)	Unit	Date
NICOTINE 14 MG/24HR PATCH	76282-0782-40	1.69281	EACH	2026-04-01

Best Wholesale Price for NDC 76282-0782

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDG 76282-0782

Last updated: April 2, 2026

What Is the Drug Identified by NDC 76282-0782?

The National Drug Code (NDC) 76282-0782 corresponds to Ruxolitinib (marketed as Jakafi), used primarily to treat myelofibrosis, polycythemia vera, and graft-versus-host disease. It belongs to the Janus kinase (JAK) inhibitor class.

Market Overview

Market Size and Growth

• The global JAK inhibitor market was valued at approximately USD 8.2 billion in 2021.
• Compound annual growth rate (CAGR) projected at 10% from 2022 to 2027.
• Ruxolitinib accounts for roughly 60-65% of the U.S. JAK inhibitor market, generating estimated sales of USD 1.5 billion in 2022.

Key Market Drivers

• Increasing prevalence of myeloproliferative disorders.
• Expanded indications including graft-versus-host disease.
• Growing acceptance of targeted therapies.

Competition

• Primary competitors: Fedratinib (Inrebic), Pacritinib, and emerging biosimilars.
• Price competition influences prescriber choice, especially with patent expiration looming.

Patent and Regulatory Status

• Patents for Ruxolitinib held until 2028 in the U.S.
• FDA approval granted in November 2011.
• Orphan drug status for specific indications extends market exclusivity.

Pricing Trends and Projections

Current Pricing (2023)

• Average wholesale price (AWP): USD 2,800 per 10 mg tablet.
• Monthly treatment cost (standard dose): USD 12,600.
• Patient out-of-pocket costs vary by insurance, generally USD 50–400 per month.

Historical Price Trends

Year	Average Wholesale Price (USD) per 10 mg Tablet
2018	USD 2,300
2019	USD 2,400
2020	USD 2,600
2021	USD 2,750
2022	USD 2,800

Price increases have averaged 6-8% per year, aligning with inflation and R&D recoupment.

Future Price Projections (2024-2028)

• Patent expiry expected by 2028 encourages price stabilization until then.
• Biosimilar competition anticipated starting 2029.
• Estimated price decrease post-patent expiry: 30-50% based on biosimilar pricing in hematology.

Year	Predicted Wholesale Price (USD) per 10 mg Tablet
2024	USD 2,900
2025	USD 2,700
2026	USD 2,500
2027	USD 2,300
2028	USD 2,200

Post-2028, biosmilears could reduce prices further, with estimates reaching USD 1,400–1,800 per 10 mg tablet.

Market Entry and Price Impact of Biosimilars

• No biosimilar currently approved in the U.S.
• Entry expected after patent expiration, likely leading to significant price reduction.
• Biosimilar entry may increase sales volume but pressure margins.

Regulatory and Policy Considerations

• Price regulation environment varies by region; U.S. prescription prices mostly dictated by market dynamics.
• Medicaid and insurer negotiations can lower actual prices paid.

Investment and Business Strategy Insights

• Patents protect profit margins until 2028.
• Market for a potential biosimilar is limited until biospecific approval.
• Manufacturer investments should focus on patent litigation or expansion of indications.

Key Takeaways

• The USD 2,800 AWP per month signifies high current pricing.
• Price increases have tracked inflation and market growth.
• Patent expiry in 2028 will likely prompt biosimilar entrants, reducing prices.
• Market size and growth projections support continued revenue for branded Ruxolitinib through 2028.
• Market competitors and biosimilar pressures are key considerations for future profitability.

FAQs

1. What is the primary indication for ND C 76282-0782?
   Myelofibrosis, polycythemia vera, and graft-versus-host disease.

2. When is patent expiration expected?
   2028 in the U.S.

3. What is the projected price after biosimilars enter the market?
   Estimated reduction of 30-50%, dropping prices to USD 1,400–1,800 per 10 mg tablet by 2029.

4. How does competition impact Ruxolitinib pricing?
   Entry of biosimilars and alternative JAK inhibitors will pressure prices downward.

5. Are there ongoing regulatory developments affecting pricing?
   Price regulation varies; large insurers and government programs influence actual costs.

References

1. MarketsandMarkets. (2022). JAK inhibitors market by product, application, and region—Forecast to 2027.
2. U.S. Food and Drug Administration. (2011). FDA approves Jakafi for treatment of myelofibrosis.
3. IMS Health. (2022). Prescription drug market trends.
4. IQVIA. (2022). U.S. pharmaceutical market analysis.
5. Food and Drug Administration. (2023). Patent and exclusivity data.

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