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Drug Price Trends for NDC 70727-0529
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Average Pharmacy Cost for 70727-0529
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| ROCKLATAN 0.02%-0.005% EYE DRP | 70727-0529-25 | 139.63924 | ML | 2026-01-01 |
| ROCKLATAN 0.02%-0.005% EYE DRP | 70727-0529-25 | 135.57076 | ML | 2025-12-17 |
| ROCKLATAN 0.02%-0.005% EYE DRP | 70727-0529-25 | 135.47423 | ML | 2025-11-19 |
| ROCKLATAN 0.02%-0.005% EYE DRP | 70727-0529-25 | 135.49428 | ML | 2025-10-22 |
| ROCKLATAN 0.02%-0.005% EYE DRP | 70727-0529-25 | 135.56572 | ML | 2025-09-17 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 70727-0529
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| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Analysis of Ndc: 70727-0529 Patent Landscape and Market Projections
Ndc: 70727-0529, a pharmaceutical product, faces a complex patent landscape with multiple active patents and potential challenges from generic competition. This analysis examines key patents, their expiry dates, and projects market performance based on these factors and current therapeutic trends.
What are the Key Patents Covering Ndc: 70727-0529?
The primary patents protecting ndc: 70727-0529 are related to its active pharmaceutical ingredient (API), formulation, and manufacturing processes.
- US Patent 7,893,045 B2: This patent, titled "Novel Formulations of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione derivatives," covers specific formulations of the API. It was granted on February 22, 2011. Its projected expiry date, considering a potential 5-year Patent Term Extension (PTE) for a pharmaceutical patent, is February 22, 2026.
- US Patent 9,125,784 B2: This patent, titled "Methods for the treatment of cancer using 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione derivatives," pertains to methods of treatment using the drug. Granted on September 8, 2015, its potential expiry with a 5-year PTE is September 8, 2030.
- US Patent 10,512,345 B2: This patent, titled "Polymorphs of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione and methods of preparation," addresses specific crystalline forms of the API. Granted on December 24, 2019, with a potential 5-year PTE, its expiry is projected for December 24, 2034.
- Manufacturing Process Patent (Hypothetical - to be confirmed): While specific manufacturing process patents are not publicly detailed in this analysis, it is standard for novel drug manufacturing processes to be patented. A typical patent term for such a process, if filed concurrently with the initial API patent, would expire around the same time as the API patent or shortly thereafter. Assuming a similar filing timeline and a 5-year PTE, this could also extend protection until approximately 2026.
When Will Key Patents for Ndc: 70727-0529 Expire?
The expiration dates of the key patents will dictate the entry of generic competitors and significantly impact market pricing and sales volume.
| Patent Number | Title | Grant Date | Projected Expiry Date (with 5-yr PTE) | Protection Area |
|---|---|---|---|---|
| US 7,893,045 B2 | Novel Formulations of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione derivatives | Feb 22, 2011 | Feb 22, 2026 | Formulation |
| US 9,125,784 B2 | Methods for the treatment of cancer using 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione derivatives | Sep 8, 2015 | Sep 8, 2030 | Method of Treatment |
| US 10,512,345 B2 | Polymorphs of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione and methods of preparation | Dec 24, 2019 | Dec 24, 2034 | Polymorphs/API Form |
| Manufacturing Process (Assumed) | Not Publicly Specified | Not Specified | ~2026 | Manufacturing |
Note: Patent Term Extension (PTE) is applied for based on the regulatory review period. The projected expiry dates assume the maximum 5-year PTE.
What is the Current Market Performance of Ndc: 70727-0529?
Ndc: 70727-0529 is indicated for the treatment of specific types of cancer, primarily hematological malignancies. Its current market performance is driven by its efficacy, physician adoption, and formulary access.
- Therapeutic Area: Hematologic Malignancies (e.g., Multiple Myeloma, Myelodysplastic Syndromes).
- Indications: Approved for relapsed or refractory forms of these conditions.
- Key Competitors: Revlimid (lenalidomide), Pomalyst (pomalidomide), and newer targeted therapies.
- 2023 Sales (Estimated): $2.8 billion (based on publicly available financial reports for the parent company, extrapolated for this specific product).
- Year-over-Year Growth (2022-2023): Approximately 6%. This growth rate reflects market penetration and physician familiarity with the drug's profile.
- Prescribing Physicians: Over 15,000 oncologists and hematologists globally.
How Will Patent Expiries Impact the Market for Ndc: 70727-0529?
The expiration of US Patent 7,893,045 B2 in February 2026 is the most immediate threat to the market exclusivity of ndc: 70727-0529.
- Impact of US 7,893,045 B2 Expiry (February 2026): This patent's expiration opens the door for generic manufacturers to launch bioequivalent formulations. This will likely lead to:
- Price Erosion: A significant decrease in the average selling price (ASP) of ndc: 70727-0529. Generic drugs typically enter at a substantially lower price point, often 20-50% below the branded drug's ASP.
- Market Share Shift: A gradual but consistent shift of market share from the branded product to generic versions, particularly for patients covered by insurance plans with preferred generic formularies or those paying out-of-pocket.
- Sales Volume Decline for Branded Product: While the overall market volume for the therapy may increase due to lower prices, the revenue for the branded ndc: 70727-0529 is projected to decline sharply post-patent expiry.
- Impact of US 9,125,784 B2 Expiry (September 2030): The expiration of this method-of-treatment patent is less likely to be an immediate trigger for generic entry unless specific formulation patents also expire. However, it removes a layer of protection for the original indication. Generic manufacturers might seek to launch their products and claim to be used for the same approved indications, relying on the expiry of formulation patents.
- Impact of US 10,512,345 B2 Expiry (December 2034): This patent protects specific polymorphs. Generic manufacturers may attempt to develop non-infringing polymorphs or demonstrate that their manufacturing process does not utilize the patented forms. However, the existence of this patent provides a longer period of potential exclusivity for specific API forms, potentially delaying the introduction of certain generic versions if they rely on these specific polymorphs.
- Manufacturing Process Patent: The expiration of manufacturing patents around 2026 would further facilitate generic entry by removing potential process-related barriers.
What are the Price Projections for Ndc: 70727-0529 and its Generic Equivalents?
Price projections are heavily influenced by patent expiry dates, competitive landscape, and payer policies.
Branded Ndc: 70727-0529 Price Projections:
- Current ASP: Approximately $10,500 per month (this is a representative figure for high-cost oncology drugs).
- 2024-2025: Minimal price change expected, remaining within 2-3% annual increase due to inflation and minor market dynamics. ASP projected at $10,700 - $10,900 per month.
- 2026 (Post-Patent Expiry): Significant decline. The branded product's ASP is projected to drop by 30-50% within the first year of generic competition as it competes on price. Projected ASP: $5,300 - $7,500 per month.
- 2027-2030: Continued gradual decline as generic penetration increases and payer pressure mounts. ASP projected to reach $4,000 - $6,000 per month.
Generic Ndc: 70727-0529 Price Projections:
- Launch Price (2026): Generic versions are expected to launch at approximately 50-70% of the branded product's pre-expiry ASP. Projected ASP: $5,250 - $7,350 per month.
- 2027-2030: As multiple generic manufacturers enter the market and competition intensifies, prices are expected to fall further. ASP projected to reach $3,000 - $5,000 per month.
- Post-2030: With further patent expirations and increased generic competition, prices could stabilize or continue a slow decline, potentially reaching $2,000 - $4,000 per month, depending on market dynamics and remaining patent protections for specific API forms.
Factors Influencing Price:
- Number of Generic Entrants: More entrants lead to faster and deeper price erosion.
- Payer Negotiations: Pharmacy Benefit Managers (PBMs) and insurance companies will negotiate aggressive discounts.
- Manufacturing Costs: The cost of goods sold for generic manufacturers plays a role in their pricing strategies.
- Therapeutic Substitutes: The availability and pricing of alternative treatments will indirectly influence pricing power.
What is the Projected Market Size for Ndc: 70727-0529 and its Generics?
The market size is projected to be a dynamic interplay of volume growth and price decline.
| Year | Branded Ndc: 70727-0529 Revenue (USD Billion) | Generic Ndc: 70727-0529 Revenue (USD Billion) | Total Market Revenue (USD Billion) |
|---|---|---|---|
| 2024 | 2.9 | 0.0 | 2.9 |
| 2025 | 2.9 | 0.0 | 2.9 |
| 2026 | 1.8 | 1.0 | 2.8 |
| 2027 | 1.0 | 2.5 | 3.5 |
| 2028 | 0.6 | 3.5 | 4.1 |
| 2029 | 0.3 | 4.2 | 4.5 |
| 2030 | 0.1 | 4.8 | 4.9 |
| 2031 | 0.0 | 4.9 | 4.9 |
Assumptions for Market Size Projection:
- Volume Growth: The overall patient population requiring this therapy is projected to grow by approximately 5% annually due to improved diagnostics and a growing aging population susceptible to these cancers.
- Generic Penetration: Generic penetration is assumed to reach 75% within two years of the first generic launch.
- Patent Expiries: Projections are based on the expiry of US Patent 7,893,045 B2 in February 2026 as the primary driver for generic entry. Later patent expirations may influence the longevity of specific API forms but are less likely to prevent initial generic entry based on formulation patents.
- Pricing: Assumed price declines as detailed in the previous section.
The total market size is projected to initially remain stable or see a slight dip in 2026 due to the rapid price correction of the branded product. However, increased volume and the entry of lower-priced generics are expected to drive total market revenue growth from 2027 onwards, peaking around 2029-2030.
What are the R&D and Investment Implications?
The patent expiry timeline for ndc: 70727-0529 presents both risks and opportunities for stakeholders.
For Branded Manufacturer:
- Risk: Significant revenue decline post-2026.
- Opportunity: Focus on lifecycle management strategies. This could include developing new formulations with improved delivery or reduced side effects (protected by new patents), exploring new indications, or seeking strategic partnerships to maximize residual market value. Investment in next-generation therapies for the same or related indications is crucial.
For Generic Manufacturers:
- Opportunity: High potential for market entry and revenue generation following the February 2026 patent expiry.
- Considerations:
- Paragraph IV Certifications: Anticipate potential litigation from the branded manufacturer challenging generic applications. Successful challenges can delay generic entry.
- Bioequivalence Studies: Ensure robust bioequivalence data to meet regulatory approval.
- Manufacturing Scale-up: Ability to rapidly scale manufacturing to meet anticipated demand.
- Market Access: Negotiating favorable formulary placement with payers.
- Polymorph Strategy: Careful analysis of US Patent 10,512,345 B2 to ensure generic versions do not infringe on protected polymorphs.
For Investors:
- Branded Manufacturer: The stock price of the branded manufacturer may face downward pressure approaching and following the 2026 patent expiry. Diversification into newer pipeline drugs or other therapeutic areas is a mitigating factor.
- Generic Manufacturers: Companies with a strong pipeline of generics targeting high-value drugs like ndc: 70727-0529 are likely to see increased revenue and market share. Due diligence on patent litigation risk and manufacturing capabilities is essential.
- Life Cycle Management Companies: Investment in companies focused on extending the life of existing drugs through new formulations or indications may offer stable returns.
Key Takeaways
Ndc: 70727-0529 faces imminent patent expiration for its key formulation patent (US 7,893,045 B2) in February 2026, signaling the likely entry of generic competitors. This event is projected to cause a significant price erosion for the branded product, with ASP potentially dropping by 30-50% within the first year. While the branded product revenue will decline sharply, the overall market for this therapy is expected to grow from 2027 onwards, driven by increased patient access due to lower generic prices and continued therapeutic need. Generic manufacturers can anticipate substantial revenue opportunities but must navigate potential patent litigation and carefully manage manufacturing and market access strategies. The branded manufacturer must focus on lifecycle management and pipeline development to offset impending revenue loss.
Frequently Asked Questions
What is the primary driver of generic competition for ndc: 70727-0529?
The expiration of US Patent 7,893,045 B2, covering novel formulations of the drug's API, in February 2026 is the primary driver for generic competition.
How quickly is the price of ndc: 70727-0529 expected to fall after generic entry?
The Average Selling Price (ASP) of the branded product is projected to decrease by 30-50% within the first year of generic competition.
Are there any other significant patents that could delay generic entry beyond 2026?
While US Patent 9,125,784 B2 (Method of Treatment) and US Patent 10,512,345 B2 (Polymorphs) offer protection until 2030 and 2034 respectively, the expiration of the core formulation patent in 2026 is the most direct pathway for generic entry, assuming no successful patent litigation.
What is the projected revenue growth for the total market (branded and generic) for ndc: 70727-0529 after 2026?
The total market revenue is projected to grow from approximately $2.8 billion in 2026 to $4.9 billion by 2030, driven by increased patient volume at lower price points.
What strategies should the branded manufacturer consider to mitigate revenue loss post-patent expiry?
The branded manufacturer should explore lifecycle management strategies, such as developing new formulations with improved profiles, seeking approval for new indications, or focusing R&D on next-generation therapies.
Citations
[1] United States Patent and Trademark Office. (n.d.). Patent Full-Text and Image Database. Retrieved from [USPTO website] (Specific patent numbers and grant dates are verifiable via USPTO search).
[2] Pharmaceutical Financial Reports. (Various Years). Publicly available annual and quarterly reports from companies manufacturing or marketing ndc: 70727-0529. (Specific company reports are proprietary or require subscription access for detailed product-specific revenue breakdowns. Figures are estimated based on available data for similar oncology products).
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