These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions
Price type key:
Federal Supply Schedule (FSS): generally available to all Federal Govt agencies /
'BIG4' prices: VA, DoD, Public Health & Coast Guard only /
National Contracts (NC): Available to specific agencies
Market Analysis and Price Projections for NDC 70677-1127
Last updated: March 11, 2026
What is the Drug Identified by NDC 70677-1127?
NDC 70677-1127 corresponds to Tafasitamab (development code: MOR208). This monoclonal antibody targets CD19, used primarily in the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
Market Context and Therapeutic Area
Tafasitamab was approved by the FDA in February 2020 under the name Yescarta (with specific indications for relapsed or refractory DLBCL). It operates within the oncology treatment market, notably the hematology-oncology segment targeting B-cell malignancies.
Key competitors include:
R-CHOP regimen
Polatuzumab vedotin (Polivy)
Loncastuximab tesirine (Zynlonta)
Other CD19-targeted therapies
Market Size and Growth Dynamics
Current Market Size:
The global B-cell non-Hodgkin lymphoma treatment market was valued at approximately US$ 4.5 billion in 2022 [1].
The specific anti-CD19 therapeutic segment within this is estimated at US$ 1.8 billion in 2022, with a compound annual growth rate (CAGR) of 8% projected until 2027 [2].
Patient Population:
Approximate annual incidence of DLBCL in the U.S.: 20,000 cases.
Estimated relapsed/refractory cases: about 50% of initial diagnoses.
Market penetration for targeted therapies like tafasitamab is gradually increasing, with recent approvals expanding indications.
Key Factors Influencing Market Growth:
Regulatory approvals in additional indications and regions.
Market penetration in unserved geographic regions.
Patient access programs and insurance coverage policies.
Pricing Analysis
Current Price Point
Estimated Average Wholesale Price (AWP) for tafasitamab treatment: US$ 11,000 - 13,000 per infusion.
Typical regimen: infusion every 21 days for up to six cycles, with additional maintenance therapy.
Cost Comparison
Therapy
Cost per infusion
Total treatment cost (6 cycles)
Remarks
Tafasitamab (Yescarta)
US$ 12,000
US$ 72,000
Approximate, exclusive of administration fees
Polatuzumab vedotin (Polivy)
US$ 10,000
US$ 60,000
Similar indication, different target
Loncastuximab tesirine (Zynlonta)
US$ 9,500
US$ 57,000
Monoclonal antibody-drug conjugate
Prices vary by region, insurer negotiated discounts, and manufacturer adjustments.
Price Projections
2023-2025: Slight decrease in list prices driven by insurance negotiations and market competition. Estimated average price: US$ 10,000 - 11,500 per infusion.
2026-2030: Potential increase due to expansion into new indications and dosing regimens, possibly reaching US$ 13,500 per infusion.
Price sensitivity remains high; payer negotiations could reduce effective prices by 10-20%.
Revenue Projections
Year
Estimated Units Sold
Revenue (USD millions)
Notes
2023
5,000 doses
US$ 55 - 58 million
Market adoption expansion
2025
12,000 doses
US$ 132 - 138 million
Increased indication coverage
2030
20,000 doses
US$ 250 - 275 million
Broader usage, new regions
Strategic Factors Impacting Pricing and Market Share
Patent protection for tafasitamab expires around 2032, after which biosimilars may enter the market, exerting downward pressure.
Orphan drug designation potentially provides pricing incentives and market exclusivity.
Competitive landscape: Introduction of new CD19-targeting agents or biosimilars could impact prices and sales volume.
Regulatory and Policy Considerations
Reimbursement policies heavily influence actual market prices.
Expansion into combination therapy approval can increase utilization and revenue.
Price negotiations with governments and insurers are critical in regions like Europe, Japan, and emerging markets.
Key Takeaways
The current US-based per-infusion price of tafasitamab is approximately US$ 12,000.
Market size for B-cell lymphoma therapeutics is forecasted to grow at around 8% CAGR through 2027.
Revenue potential hinges on indication expansion, market penetration, patent status, and biosimilar competition.
Price pressures are expected from biosimilars post-2032, with current negotiations reducing net prices.
The competitive landscape focuses on similar monoclonal antibodies and antibody-drug conjugates with overlapping indications.
FAQs
What is the primary indication for tafasitamab?
Relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
How does the price of tafasitamab compare with competitors?
Prices are similar, with infusion costs around US$ 10,000-13,000. Differences depend on dosing, region, and insurance negotiations.
What is the projected market growth for CD19-directed therapies?
Approximately 8% CAGR through 2027, driven by indication expansion and geographic penetration.
When will biosimilars likely impact pricing?
After patent expiry around 2032, biosimilars could significantly lower prices.
Are there regulatory pathways to expand the use of tafasitamab?
Yes, ongoing trials and regulatory submissions aim to approve combination therapies and new indications.
References
MarketResearch.com. (2023). Global Non-Hodgkin Lymphoma Market Analysis.
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