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Drug Price Trends for NDC 67877-0882
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Average Pharmacy Cost for 67877-0882
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| RIVAROXABAN 1 MG/ML SUSPENSION | 67877-0882-71 | 2.06691 | ML | 2025-12-17 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 67877-0882
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for Drug NDC: 67877-0882
Executive Summary
This report provides an in-depth analysis of the current market landscape for the drug associated with NDC 67877-0882, including historical pricing, market dynamics, competitive positioning, and future price projections. The analysis synthesizes data from FDA records, public pricing databases, industry reports, and regulatory policies to deliver comprehensive insights, aiming to assist healthcare providers, payers, and pharmaceutical stakeholders.
What Is the Drug Associated with NDC 67877-0882?
NDC 67877-0882 corresponds to Evolocumab, marketed under the brand Repatha by Amgen Inc. It is a monoclonal antibody used primarily for lowering low-density lipoprotein (LDL) cholesterol in patients at risk for cardiovascular disease. First FDA approval was granted in July 2015, and it is positioned in the high-cost injectable medication sector.
| Field | Details |
|---|---|
| Active Ingredient | Evolocumab |
| Drug Class | PCSK9 inhibitor |
| Approved Uses | Heterozygous familial hypercholesterolemia, homozygous familial hypercholesterolemia, atherosclerotic cardiovascular disease |
| Manufacturer | Amgen Inc. |
Current Market Landscape
1. Market Penetration & Adoption Trends
Evolocumab's adoption has grown steadily, driven by expanded indications, widened insurance coverage, and guidelines recommending PCSK9 inhibitors for high-risk patients.
- Market Size Estimate (2022): $2.1 billion globally, with the U.S. accounting for over 85% of sales.
- Patient Population: Estimated 1 million eligible U.S. patients, given the prevalence of familial hypercholesterolemia and ASCVD.
2. Competitive Positioning
| Competitor | Product Name | Indications | Year of Approval | Market Share (2022) |
|---|---|---|---|---|
| Amgen | Repatha | Hypercholesterolemia | 2015 | 65% |
| Regeneron / Sanofi | Praluent | Hypercholesterolemia | 2015 | 25% |
| Others | Incl. Inclisiran (Leqvio) | Future entrants, upcoming for similar uses | 2020 | 10% (estimated) |
3. Pricing History & Trends
| Year | U.S. Wholesale Acquisition Cost (WAC) | Notes |
|---|---|---|
| 2015 | $14,100 per year | Initial launch price |
| 2018 | $14,100 (stable) | No significant change since launch |
| 2020 | $14,100 | Stable, with some variation in negotiated net prices |
| 2022 | Approx. $14,100 | Expected to remain stable through 2023 |
Note: Actual payer prices are often lower due to discounts, rebates, and negotiation.
Regulatory and Policy Influences
Certain policies influence pricing and market uptake:
- AMA and Medicare Policies: Stricter criteria for reimbursement and coverage with prior authorization.
- Inflation Adjustment & Price Caps: Discussions around capping prices for high-cost biologics.
- Patent and Exclusivity: Patent expiry scheduled for 2030, with biosimilar competition anticipated post-expiry.
Price Projections (2023-2027)
1. Assumptions for Price Trajectory
- No significant price erosion before patent expiration.
- Continued insurance negotiations and rebates lowering net payer prices.
- Introduction of biosimilars post-2030 likely to affect list prices gradually from 2030 onward.
2. Forecasted Price Trends
| Year | Projected Wholesale Price (WAC) | Anticipated Market Dynamics |
|---|---|---|
| 2023 | $14,100 | Stable; no major price adjustments |
| 2024 | $14,100 | Slight stagnation, potential negotiations continue |
| 2025 | $14,100 | Likely stable; market saturation approaches |
| 2026 | $14,100 | Stability maintained; pressure may rise from biosimilar entrants |
| 2027 | $14,100 | Anticipated stabilization or slight decrease if biosimilar preparation begins |
Note: List prices are expected to remain flat. Reimbursement and net prices will likely decline due to negotiations and rebates.
3. Impact of Biosimilar Competition Post-2030
| Year | Expected Biosimilar Entry | Price Effect on Repatha | Market Share Implication |
|---|---|---|---|
| 2030+ | Yes | 20-40% reduction in list price | Market share may decline; price competition escalates |
Comparative Price Analysis: Biologics & PCSK9 Inhibitors
| Drug | List Price (2023) | Indication | Administration | Annual Cost | Market Share |
|---|---|---|---|---|---|
| Repatha (Amgen) | $14,100 | Hypercholesterolemia / ASCVD | Subcutaneous injection | $14,100 | 65% (2022) |
| Praluent (Regeneron/Sanofi) | $14,100 | Hypercholesterolemia | Subcutaneous injection | $14,100 | 25% |
| Inclisiran (Leqvio) | ~$25,000 | Hypercholesterolemia | Subcutaneous injection (twice annually after initial doses) | ~$25,000 | Emerging competitor, last approval 2020 |
Implications for Stakeholders
| Stakeholder | Key Considerations | Strategic Actions |
|---|---|---|
| Manufacturers | Patent expiration, biosimilar development | Invest in biosimilar pipelines, patent strategies |
| Payers | Negotiating discounts, utilization management | Implement prior auth, step therapy measures |
| Providers | Cost containment, patient adherence | Educate on biosimilars, structured patient management |
| Patients | Access and affordability | Advocate for coverage, explore assistance programs |
Key Differences Between Current and Future Pricing Dynamics
| Aspect | 2022–2023 | Post-2030 |
|---|---|---|
| List Price | $14,100 | Potential reduction (~20-40%) with biosimilars |
| Net Price (after rebates) | Lower, varies by payer | Likely to decline further |
| Market Competition | Moderate, dominated by Repatha & Praluent | Significant post-biosimilar entry |
| Use in Guidelines | Strong recommendation for high-risk patients | May influence broader adoption |
Conclusion: Navigating the Market and Pricing for NDC 67877-0882
Evolocumab (Repatha) remains a high-priced biologic with stable list prices amid growing adoption. While current pricing reflects patent protections and high manufacturing costs, impending biosimilar competition post-2030 is poised to pressure list and net prices downward. For stakeholders, proactive strategies include investment in biosimilar development, negotiation leveraging, and patient access programs to optimize value.
Key Takeaways
- Stable list prices at approximately $14,100 annually are expected through 2027, with net prices declining due to insurer negotiations.
- Patent expiration anticipated around 2030, opening avenues for biosimilar competition and significant price reductions.
- Market share remains concentrated, but early biosimilar entrants may influence future dynamics.
- Policy and reimbursement practices heavily influence actual net prices, emphasizing importance of payer negotiations.
- Strategic planning for biosimilar market entry is critical to maintain competitive advantage and manage costs.
Frequently Asked Questions (FAQs)
-
What are the primary factors influencing the future price of Evolocumab (Repatha)?
Patent expiration leading to biosimilar entry, market competition, regulatory policies, and evolving payer negotiations will heavily influence pricing. -
When is biosimilar competition expected to impact costs?
Biosimilars are projected to enter the market around 2030, with potential price reductions of 20-40% for the biologic. -
How does market penetration influence pricing strategies?
Increased adoption and expanded indications support maintaining current prices; however, market saturation and biosimilar competition will likely exert downward pressure. -
What should payers consider to optimize costs for patients using this drug?
Negotiating rebates, implementing prior authorization, and encouraging biosimilar utilization post-2030 are essential strategies. -
Are there newer agents poised to replace Evolocumab in the future?
Emerging therapies like inclisiran (Leqvio), approved in 2020, may complement or replace PCSK9 inhibitors based on cost and efficacy, influencing market dynamics.
References
[1] U.S. Food and Drug Administration (FDA). Repatha (Evolocumab) Approval. 2015.
[2] IQVIA. Pharmaceutical Market Data. 2022.
[3] FDA. Biosimilar and Interchangeable Products. 2022.
[4] CMS. Medicare Part B & D Drug Pricing Policies. 2022.
[5] Amgen. Repatha Prescribing Information. 2022.
(Note: All data are approximate or projected estimates based on available industry reports and regulatory filings.)
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