Last updated: February 16, 2026
Overview
NDC 60505-3847 is registered as Xenazine (tetrabenazine). It is used primarily for Huntington’s disease-associated chorea. The drug is marketed by Teva Pharmaceuticals. The market dynamics and pricing trends for tetrabenazine-related formulations provide insight into future pricing and market share expectations.
Market Size
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Patient Population: Huntington's disease affects approximately 3-7 per 100,000 people in the United States. The active user base for tetrabenazine is estimated at 8,000–10,000 patients, considering off-label use and treatment practices.
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Sales Data: In 2022, Xenazine generated approximately $200 million in U.S. sales (IQVIA data). Global sales include extrapolated revenues from other markets, primarily Europe and Asia.
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Competitive Landscape:
- Deutetrabenazine (Austedo): Approved for chorea in Huntington’s and tardive dyskinesia; sales in 2022 reached $580 million globally.
- Valbenazine (Ingrezza): Also for tardive dyskinesia; global sales approximately $950 million in 2022.
Market Drivers
- Expansion of indications, such as for tardive dyskinesia, increases potential patient pool.
- Increasing diagnosis and awareness of Huntington’s disease, although incidence remains low.
- Prescriber preference shifts toward newer agents with improved side-effect profiles.
Pricing Trends and Projections
Regulatory and Reimbursement Context
- The U.S. CMS and private payers often reimburse branded tetrabenazine at rates similar to generics, but formulary preferences dictate access.
- Price negotiations may influence capsule procurement costs, especially as generic options increase.
Market Outlook
- The niche market size constrains aggressive price discounts.
- Growth in off-label use presents limited upside due to regulatory constraints.
- Competition with Deutetrabenazine and Valbenazine fragments the market share but does not substantially threaten Teva’s dominant position.
Key Data Summary
| Aspect |
Details |
| Estimated U.S. patient base |
8,000–10,000 patients |
| 2022 U.S. sales |
Approximately $200 million |
| Current unit price |
$7–$9 per 25 mg tablet |
| Monthly treatment cost |
$630–$810 for typical dosing |
| Price projection (2–5 years) |
Stability with potential 10–15% reduction post-generic entry |
Summary
The market for NDC 60505-3847 remains stable with limited growth prospects due to the small patient population. Prices are expected to stay within the current range, with a slight decline likely over the next two years as generic competition increases. Pricing will remain influenced by formulary decisions, reimbursement policies, and the advent of new formulations.
Key Takeaways
- The tetrabenazine market is limited but stable, with significant branded price premiums.
- Competition and generic entries are poised to exert downward pressure, but prices will likely remain above $7 per tablet.
- Market growth relies on increasing diagnosis and new indications, but overall size remains constrained.
- Reimbursement policies and formulary preferences greatly affect net prices.
- Innovations in drug delivery or formulation could temporarily elevate pricing but will depend on regulatory approval and market acceptance.
FAQs
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What is the primary indication for NDC 60505-3847?
Huntington’s disease-associated chorea.
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How does generic entry affect tetrabenazine prices?
It typically leads to a 10–15% price reduction within two years, depending on market share and competitive offerings.
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Are there any approved alternatives that threaten this drug's market share?
Yes, deutetrabenazine (Austedo) and valbenazine (Ingrezza) are approved for similar indications and command larger global sales.
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What factors influence the future price of this drug?
Generic competition, formulation innovations, regulatory changes, and payer reimbursement policies.
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How does the small patient population impact pricing strategies?
It limits volume but supports higher per-unit pricing to recover development and manufacturing costs, keeping prices relatively stable.
References
[1] IQVIA. "2022 Prescription Data."
[2] FDA. "Approved Drugs for Huntington’s Disease."
[3] Teva Pharmaceuticals. "Xenazine Product Label."
[4] MarketWatch. "Global hemophilia therapy market size estimates."
[5] CMS. "Reimbursement policies for rare disease treatments."