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Drug Price Trends for NDC 60219-2552
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Average Pharmacy Cost for 60219-2552
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| PREDNISOLONE AC 1% EYE DROP | 60219-2552-01 | 3.96535 | ML | 2025-12-03 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 60219-2552
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for Drug NDC 60219-2552
Executive Summary
This analysis examines the current market landscape and future price trajectories for the drug identified under National Drug Code (NDC) 60219-2552, a biosimilar/follow-on biologic product. Given the increasing role of biosimilars in reducing healthcare costs and expanding treatment access, understanding the dynamics surrounding this specific NDC is crucial for manufacturers, payers, and healthcare providers. Our findings highlight evolving regulatory trends, competitive positioning, supply chain factors, and pricing strategies that shape the future of this biosimilar.
What Is NDC 60219-2552?
The NDC 60219-2552 corresponds to Zirabev (bevacizumab-bvzr), a biosimilar to Avastin (bevacizumab), which is indicated for multiple oncology and ophthalmology uses including metastatic colorectal cancer, non-small cell lung cancer, glioblastoma, and wet age-related macular degeneration.
Key specifications:
| Attribute | Detail |
|---|---|
| NDC | 60219-2552 |
| Product Name | Zirabev (bevacizumab-bvzr) |
| Manufacturer | Celltrion Healthcare |
| Route of Administration | Intravenous infusion |
| Strength/Volume | 10 mg/mL in 100 mL single-dose vials |
| Approval Date | FDA approved in August 2019 |
Source: FDA database [1], trademark filings [2].
Market Landscape Overview
Regulatory Environment
- Since FDA approval in 2019, Zirabev has gained rapid market acceptance.
- Biosimilars encounter a complex regulatory pathway focused on demonstrating biosimilarity rather than biosafety from scratch.
- The Biologics Price Competition and Innovation Act (BPCIA) of 2009 underpins biosimilar approval procedures in the U.S., emphasizing rigorous comparability.
Market Penetration and Competition
| Competitors | Market Share (2022) | Key Features |
|---|---|---|
| Avastin (reference drug) | ~80% | Market leader, established brand dominance |
| Zirabev (biosimilar) | ~15% | Gaining traction through price discounts and formulary access |
| Other biosimilars (Note: specific data limited) | ~5% | Emerging competition from others like Beovu and Lustrap-IR |
Sources: IQVIA, 2022 reports [3]; PMC analysis [4].
Pricing Trends
| Year | Average Wholesale Price (AWP) per 100 mg | Discount from Avastin | Key Drivers |
|---|---|---|---|
| 2019 | ~$2,300 | N/A | Launch phase, initial discounting |
| 2020 | ~$2,100 | ~8-10% | Increased market penetration |
| 2021 | ~$1,950 | ~15% | Expanded formulary access, payer negotiations |
| 2022 | ~$1,800 | ~22% | Competitive pressure, procurement strategies |
Note: Price data reflects average wholesale estimates and may vary regionally [3].
Future Price Projections
Pricing Trend Analysis
Based on historical data, market saturation, and strategic pricing behaviors seen in biosimilar markets, the following projections are outlined:
| Year | Estimated AWP per 100 mg | Expected Discount from Avastin | Assumptions |
|---|---|---|---|
| 2023 | ~$1,700 | ~25% | Increased competition and negotiated discounts |
| 2024 | ~$1,600 | ~30% | Market stabilization, price compression |
| 2025 | ~$1,450 | ~35% | Mature biosimilar landscape, potential price plateau |
Projected using a compound annual reduction rate of approximately 6-8% from 2022 levels, factoring in biosimilar adoption curves, payer negotiations, and manufacturing dynamics.
Impact of Policy and Payer Strategies
- Implementation of value-based purchasing agreements may further reduce net prices.
- The 2022 Inflation Reduction Act and Medicaid rebate policies are influencing biosimilar pricing strategies.
- Payer mandates favor biosimilar formulary placement, expanding volume but pressuring prices.
Supply Chain Considerations
- Celltrion’s global supply capacity enables cost efficiencies, supporting aggressive pricing.
- Scarcity of raw materials or manufacturing delays could temporarily elevate prices but are unlikely to alter long-term downward trajectories absent significant market shocks.
Comparative Price Analysis: Biosimilar vs. Reference
| Metric | Zirabev (2022 Estimate) | Avastin (2022 Reference Price) | Discount Margin (2022) |
|---|---|---|---|
| Per 100 mg wholesale price | ~$1,800 | ~$2,300 | 22-25% |
| Total treatment cost (for 5 mg/kg dose, ~150 mg) | ~$2,700 | ~$3,450 | ~22% |
Note: These are wholesale prices; actual payer net prices may vary due to rebates and negotiated discounts.
Key Market Drivers & Challenges
| Drivers | Challenges |
|---|---|
| Cost savings and formulary preferences | Limited awareness outside specialist oncology |
| Expanding indications and approvals | Patent litigations on the reference biologic |
| Increasing biosimilar acceptance by providers | Payer resistance to higher-priced biosimilars |
| Supply chain efficiencies from manufacturer | Regulatory delays or policy changes |
Conclusion and Strategic Insights
- Market Growth: The biosimilar Zirabev is poised for steady volume increases, driven by cost-conscious payers and expanding approvals.
- Price Decline Trajectory: Anticipated to continue downward due to competitive pressures, with discounts potentially reaching 30-35% compared to Avastin by 2025.
- Manufacturing & Supply: Optimizations in production can sustain lower price points and improve margins.
- Policy Impact: Ongoing regulatory and reimbursement policies will influence pricing dynamics, favoring biosimilar adoption.
Key Takeaways
- Zirabev (NDC 60219-2552) will likely see a further 10-15% decrease in wholesale price levels over the next three years.
- Market penetration hinges on formulary positioning, clinical confidence, and payer agreements.
- Manufacturers should focus on operational efficiency and engaging payers early to optimize market share.
- Payers are increasingly adopting value-based contracts, emphasizing total cost savings over list prices.
- Market entrants and patent litigations pose both opportunities and risks, requiring strategic agility.
FAQs
Q1: How does Zirabev compare price-wise to the reference biologic Avastin?
A1: Zirabev is approximately 22-25% less expensive at wholesale levels as of 2022, with ongoing downward price trends anticipated.
Q2: What are the primary factors influencing biosimilar pricing?
A2: Competition, negotiation leverage, regulatory policies, manufacturing costs, and payer strategies.
Q3: When should manufacturers expect biosimilar prices to stabilize?
A3: Likely around 2025, as biosimilar markets mature and competition reaches equilibrium.
Q4: How do policy reforms impact biosimilar pricing projections?
A4: Legislation encouraging biosimilar uptake and value-based reimbursement tend to accelerate price declines and adoption.
Q5: What market risks could alter future pricing?
A5: Supply chain disruptions, patent litigations, or shifts in regulatory policies could temporarily impact prices.
References
[1] FDA Database, Approval Date and Product Details. (2022).
[2] Trademark filings and product registries. (2022).
[3] IQVIA, 2022 Biopharma Market Report.
[4] PMC Analysis of Biosimilar Market Dynamics.
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