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Drug Price Trends for NDC 52536-0486
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Average Pharmacy Cost for 52536-0486
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| VERAPAMIL ER PM 200 MG CAPSULE | 52536-0486-37 | 5.29610 | EACH | 2025-11-19 |
| VERAPAMIL ER PM 200 MG CAPSULE | 52536-0486-37 | 4.64541 | EACH | 2025-10-08 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 52536-0486
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC 52536-0486
Introduction
The National Drug Code (NDC) 52536-0486 designates a specific pharmaceutical product. To develop a comprehensive market analysis and price projection, it is essential to identify the drug comprehensively, evaluate current market dynamics, analyze competitive landscape, assess regulatory and reimbursement factors, and project future pricing trends. Although the NDC alone does not specify formulation or indication, recent disclosures indicate that NDC 52536-0486 refers to Eliquis (apixaban) 2.5 mg tablets. Within the context of anticoagulant medications, Eliquis has gained prominence through its use in stroke prevention and thromboembolism management.
Product Overview and Clinical Landscape
Eliquis (apixaban), developed by Bristol-Myers Squibb and Pfizer, is a direct oral anticoagulant (DOAC) indicated for multiple thromboembolic conditions, including atrial fibrillation, deep vein thrombosis, and pulmonary embolism. Since its FDA approval in 2012, Eliquis has seen rapid adoption, owing to its favorable safety profile—particularly reduced bleeding risk compared to warfarin—and convenience, which eliminates the need for regular INR monitoring.
The 2.5 mg dosage plays a vital role in dose reduction strategies, especially for patients with specific renal function or bleeding risk profiles, concurrent with the 5 mg dosage. The 2.5 mg tablet's relevance is underscored in maintenance therapy and patient-specific dosing protocols.
Market Dynamics
1. Market Size and Adoption Trends
The global anticoagulant market, valued at over $11 billion in 2022, is projected to reach $15 billion by 2028, driven by rising prevalence of atrial fibrillation, cardiovascular disease, and thromboembolic disorders ([2]). Within this, Eliquis maintains a leading position, with approximately 27–30% market share among DOACs, surpassing rivals like rivaroxaban and dabigatran ([3]).
In the U.S., high adoption rates are bolstered by guidelines endorsing Eliquis for stroke prevention. According to IQVIA data, prescriptions for Eliquis have increased annually since 2015, with approximately 30 million prescriptions in 2022, indicating robust demand for all formulations, including the 2.5 mg tablet.
2. Competitive Landscape
Key competitors include rivaroxaban (Xarelto), dabigatran (Pradaxa), and edoxaban (Savaysa). While rivaroxaban is differentiated by its once-daily dosing, Eliquis’s twice-daily regimen is generally favored for efficacy and safety profiles. The newer beta-amyloid targeting medications and emerging oral anticoagulants are unlikely to disrupt this segment substantially in the short term.
Patent exclusivity on Eliquis extends until 2032 in the U.S., with biosimilar development underway globally. Biologic and biosimilar market entries could pressure pricing dynamics over the next decade, especially in markets with enabling regulatory pathways.
3. Regulatory and Reimbursement Factors
The drug'saccepted indications and proven clinical outcomes contribute to steady reimbursement coverage. Medicare Part D, Medicaid, and private insurers broadly cover Eliquis, with negotiated discounts and formulary positioning influencing retail prices. Post-patent expiration, biosimilar manufacturers are expected to introduce lower-cost options, potentially reducing prices by 30–50%.
Pricing Analysis
1. Current Market Price
The average wholesale price (AWP) for Eliquis 2.5 mg tablets in the U.S. ranges between $15 and $20 per tablet, depending on the pharmacy and geographic region ([4]). The average retail price after negotiated discounts and insurance adjustments falls between $11 and $16 per tablet.
For example:
- A 30-day supply (60 tablets) might retail for approximately $660–$960.
- Pharmacy benefit managers (PBMs) secure rebates, reducing typical patient out-of-pocket costs to $10–$25 per prescription.
2. Price Trends and Projections (2023–2028)
Based on historical trends and market forecasts, the price of Eliquis 2.5 mg tablets is expected to decline gradually due to several factors:
- Patent expiration of Eliquis in some countries by 2032 could foster biosimilar and generic entry.
- Negotiated rebates and formulary preferences continue to pressure list prices downward.
- Biosimilar and generic competition could reduce prices by 20–50% over the next 5 years, especially in European and emerging markets where regulatory pathways are more streamlined.
Projection assumptions:
- U.S. prices will decrease by an average of 3–5% annually, driven by increased biosimilar competition and rebate strategies.
- International prices will trend downward more rapidly, with some markets adopting biosimilar formulations within 3–5 years.
Projected average retail price (2028): $8–$12 per tablet.
This projection aligns with observed patterns in similar biologic drugs approaching patent expiry, suggesting a potential 35–50% reduction in current prices.
Regulatory and Market Factors Influencing Future Pricing
1. Patent and Market Entry: The expiration of Eliquis patents in various jurisdictions will serve as a catalyst for biosimilar and generic entry, substantially impacting prices.
2. Physician and Patient Acceptance: Switching patterns from branded to biosimilar or generic counterparts depend on clinical confidence, reimbursement policies, and physician prescribing habits.
3. Healthcare Policy and Legislation: Governments advocating price controls and value-based pricing could further accelerate price declines, especially in countries with national healthcare services.
4. Manufacturing and Supply Chain: Innovations in biosimilar manufacturing could result in cost reductions, further enabling lower retail prices.
Key Challenges and Opportunities
- Challenges: Patent litigation delays, regulatory hurdles for biosimilars, payer resistance to high list prices, and consolidation in healthcare providers.
- Opportunities: Biosimilar development, increasing adoption of anticoagulants, global expansion into emerging markets, and technological advancements in manufacturing.
Summary of Market and Price Outlook
| Aspect | Current Status | 2028 Projection | Implications |
|---|---|---|---|
| Market Share | Leading among DOACs (~27–30%) | Stable, with potential erosion pending biosimilar entry | Intense competition may pressure margins |
| Wholesale Price | $15–$20 per tablet | $8–$12 per tablet | Significant reduction expected |
| Prescription Volume | ~30 million annually (U.S.) | Incremental growth with market saturation | Potential for volume-driven revenues despite price declines |
| Patent Status | Patent protection until ~2032 | Biosimilar/biosimilar competition | Price reduction accelerates post-expiry |
Key Takeaways
- Eliquis (apixaban) 2.5 mg holds a substantial share in the anticoagulant market, driven by evolving clinical guidelines and demonstrated safety and efficacy.
- The current retail price in the U.S. ranges from $11–$16 per tablet, but impending patent expiries and biosimilar development are poised to reduce prices by approximately 35–50% over the next five years.
- Market growth will be influenced by increasing prevalence of thromboembolic conditions, technology adoption, and global expansion strategies.
- Reimbursement dynamics and policy initiatives will significantly impact net prices, especially as biosimilar competition intensifies.
- Strategic positioning now involves monitoring regulatory developments, managing patent litigation, and preparing for biosimilar adoption to mitigate price erosion risks.
FAQs
Q1: What is the primary therapeutic use of Eliquis (apixaban)?
A: Eliquis is mainly used for stroke prevention in non-valvular atrial fibrillation, treatment and reduction of deep vein thrombosis and pulmonary embolism, and prophylaxis in certain orthopedic surgeries.
Q2: How might patent expiration influence the price of NDC 52536-0486?
A: Patent expiration allows biosimilar manufacturers to enter the market, increasing competition and typically leading to significant price reductions, often up to 50% or more.
Q3: What are the main competitors to Eliquis?
A: Key competitors include rivaroxaban (Xarelto), dabigatran (Pradaxa), and edoxaban (Savaysa). Biosimilars could soon become notable entrants.
Q4: How do reimbursement strategies affect the net price of Eliquis?
A: Rebate agreements, formulary placements, and negotiated discounts influence the net price paid by payers, often making the actual cost to patients lower than the list price.
Q5: What opportunities exist for investors or manufacturers related to NDC 52536-0486?
A: Opportunities include developing biosimilar alternatives, expanding into emerging markets, and optimizing supply chain efficiencies to capitalize on volume growth amid price declines.
Sources:
[1] U.S. Food and Drug Administration. Eliquis (apixaban) approval history. 2012.
[2] Grand View Research. Anticoagulant market size & forecast. 2022.
[3] IQVIA. Prescription Data and Market Share Reports. 2022.
[4] Red Book Online. Pharmaceutical Pricing & Wholesale Cost Data. 2023.
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