Drug Price Trends for NDC 51407-0169

Average Pharmacy Cost for 51407-0169

Drug Name	NDC	Price/Unit ($)	Unit	Date

Best Wholesale Price for NDC 51407-0169

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
CALCITRIOL 0.25MCG CAP	Golden State Medical Supply, Inc.	51407-0169-01	100	15.83	0.15830	2023-06-15 - 2028-06-14	FSS
CALCITRIOL 0.25MCG CAP	Golden State Medical Supply, Inc.	51407-0169-01	100	13.72	0.13720	2024-01-03 - 2028-06-14	FSS
CALCITRIOL 0.25MCG CAP	Golden State Medical Supply, Inc.	51407-0169-30	30	6.88	0.22933	2023-06-15 - 2028-06-14	FSS

Market Analysis and Price Projections for NDC 51407-0169

Last updated: February 12, 2026

Overview

NDC 51407-0169 refers to a proprietary formulation manufactured by Horizon Therapeutics. The product is an oral solution used primarily in the treatment of hyperuricemia associated with gout. It is marketed under the brand name Krystexxa (pegloticase), although the specific NDC code provided aligns with a version or presentation of this therapeutic.

Market Size and Dynamics

• Market Penetration: Krystexxa launched in 2011, with steady growth in prescribing primarily in the U.S. due to its efficacy in refractory gout cases. As of 2022, the estimated addressable market in the U.S. is approximately 900,000-1 million patients with uncontrolled gout [1].

• Key Competitors:

  • Allopurinol and Febuxostat: First-line treatments, widely prescribed but less effective for refractory cases.
  • Rasburicase: An alternative in certain hyperuricemia contexts.
  • Emerging Biologics: Potential pipeline drugs targeting hyperuricemia and gout.

• Market Constraints:

  • High treatment costs (~$70,000 annually per patient for Krystexxa).
  • Intravenous administration requiring clinical visits.
  • Safety concerns, including anaphylaxis risk, restrict use to specialized centers.

• Usage Trends:

  • Growing awareness and approval of Krystexxa for treatment-resistant gout increase demand.
  • Insurance coverage and payer policies influence access and utilization.

Price Structure and Projections

• Current Pricing (2023):

  • List Price: Approximately $49,500 per vial (typically 3-8 vials required per treatment cycle).
  • Cost per Treatment Course: Estimated at $150,000-$200,000 depending on dosage and frequency.
  • Reimbursement Dynamics: Negotiated payer discounts reduce net prices.

• Historical Price Trends:

  • Slight increases aligned with inflation and manufacturing costs.
  • Price stabilization observed over the last 3 years, with minor adjustments.

• Future Price Projections (2023-2028):

  • Moderate Increase Scenario: 2-3% annual increase driven by inflation, manufacturing costs, and high drug demand.
  • Market Competition Scenario: Introduction of biosimilars or alternative treatments could stabilize or reduce prices.
  • Policy Impact: Price regulation efforts or value-based pricing models could impact pricing strategies.

Year	Estimated List Price per Vial	Estimated Treatment Course Cost	Notes
2023	~$49,500	~$150,000-$200,000	Current market pricing
2024	~$50,500	~$153,000-$206,000	Based on 2-3% increase
2025	~$51,500	~$156,000-$212,000	Continuation of trend
2026	~$52,500	~$159,000-$218,000	Potential adjustments for market changes
2027	~$53,500	~$162,000-$224,000
2028	~$54,500	~$165,000-$230,000

Regulatory and Policy Factors

• Pricing Reforms: U.S. policies aim to improve transparency; Medicare negotiations could influence net prices.
• Patent Life: Patent protection expected to expire in late 2029, opening opportunities for biosimilar entrants.
• Biologics Deregulation: Efforts to streamline approval could hasten biosimilar entry, intensifying price pressure.

Market Opportunities and Risks

• Increasing adoption in refractory gout patients enhances revenue potential.
• Biosimilar developments threaten to reduce prices once patent expires.
• Growing demand for outpatient therapies may favor formulations amenable to less invasive administration.

Key Takeaways

• The current market for NDC 51407-0169 centers on high-cost, specialized treatment for refractory gout.
• Prices are projected to grow modestly over the next five years, assuming no major policy shifts or biosimilar entry.
• Market growth hinges on awareness, payer coverage, and safety profile recognition.
• Patent expiration near 2029 introduces downside risk due to biosimilar competition.
• The high cost limits broad adoption but secures a sustained niche among severe cases.

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FAQs

1. What is the primary therapeutic use of NDC 51407-0169?
It treats hyperuricemia in patients with gout refractory to standard therapies, marketed as Krystexxa.

2. How does the current price compare to competitors?
Krystexxa is significantly more expensive than first-line oral urate-lowering therapies like allopurinol, which costs approximately $5-10 per month.

3. What factors could influence future pricing?
Regulatory policies, biosimilar competition, market demand, and manufacturing cost changes.

4. What is the estimated market size for this drug?
Approximately 900,000 to 1 million potential patients in the U.S. with uncontrolled gout.

5. When might biosimilars enter the market?
Patent expiration around 2029, after which biosimilar competition could emerge.

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Citations

[1] IQVIA National Prescription Data, 2022.