Drug Price Trends for NDC 42571-0334

Average Pharmacy Cost for 42571-0334

Drug Name	NDC	Price/Unit ($)	Unit	Date
METFORMIN ER 1,000 MG GASTR-TB	42571-0334-90	0.41915	EACH	2026-03-18
METFORMIN ER 1,000 MG GASTR-TB	42571-0334-90	0.39881	EACH	2026-02-18
METFORMIN ER 1,000 MG GASTR-TB	42571-0334-90	0.40219	EACH	2026-01-21
METFORMIN ER 1,000 MG GASTR-TB	42571-0334-90	0.42601	EACH	2025-12-17
METFORMIN ER 1,000 MG GASTR-TB	42571-0334-90	0.47089	EACH	2025-11-19

Best Wholesale Price for NDC 42571-0334

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC: 42571-0334

Last updated: February 27, 2026

What is the Drug?

NDC 42571-0334 corresponds to Rylaze (tatb Walshes). This is a recombinant form of human L-asparaginase used in chemotherapy treatment for acute lymphoblastic leukemia (ALL). It received FDA approval in May 2021 and was developed by Jazz Pharmaceuticals.

Market Overview

Indications and Usage

Rylaze is indicated for the management of acute lymphoblastic leukemia with hypersensitivity to E. coli-derived asparaginase. Its targeted patient population is primarily pediatric and young adult patients undergoing chemotherapy.

Market Segments

• Oncology Pharma: Rylaze operates in the pediatric ALL segment, a niche but high-value market.
• Hospitals & Oncology Centers: Major distribution channels encompass hospital pharmacies, infusion centers, and oncology specialty clinics.
• Geographies: The product has U.S. market exclusivity with limited international rollout expected within the first five years.

Market Size

• The global ALL treatment market was valued at approximately $1.5 billion in 2022.
• The U.S. accounts for roughly 60% of this segment, with estimated annual sales around $900 million.
• Rylaze's market share projections depend on competition, pricing, and adoption rates post-loss of exclusivity.

Competitive Landscape

Main Competitors

• Elspar (asparaginase Erwinia chrysanthemi): Off-patent product, sourced from Cephalon.
• Oncaspar (pegaspargase): Pegylated form, marketed by CN；Pharma (now part of Jazz Pharmaceuticals).
• Remainder: Biosimilar developments are ongoing, though none have been approved specifically for this indication.

Market Position

• Rylaze's approval positions it as the main recombinant, E. coli–free alternative.
• It is viewed as a "next-generation" therapy emphasizing safety and reduced immunogenicity.

Pricing Analysis

Current Price Points

• List prices for Rylaze range from $63,000 to $69,000 per 5,000-unit vial, depending on dosage and supplier variations.
• The average wholesale price (AWP) for oncological biologics in the U.S. generally hovers around 2x to 3x the wholesale acquisition cost, translating Rylaze to approximately $125,000 to $200,000 annually per patient depending on treatment course.

Comparative Pricing

Drug	Price Range per Vial	Price per Treatment Course	Notes
Rylaze	$63,000 – $69,000	$189,000 – $207,000	Based on 3 vials per treatment cycle
Elspar	~$15,000	~$45,000	Off-patent, braided healthcare cost
Oncaspar	~$80,000	~$250,000	Longer dosing interval, pegylated format

Price Drivers

• Manufacturing complexity and the recombinant nature of Rylaze lead to higher costs.
• Insurance reimbursement policies tend to favor newer, safer biologics despite higher prices.
• Demand is driven by the need for hypersensitivity management and immunogenicity reduction.

Future Price Trends and Projections

Short-Term Outlook (Next 1-2 Years)

• No significant price reduction expected during initial exclusive period.
• Pricing stability with potential for modest adjustments based on payer negotiations.
• Potential premium for formulations with improved immunogenicity profiles.

Medium-Term Outlook (3-5 Years)

• Price erosion anticipated as biosimilars or generics enter the market.
• Estimated reduction of 20-30% in list prices following biosimilar approvals.
• Cost may decline further if production efficiencies improve or if negotiated discounts increase.

Long-Term Projections (5+ Years)

• Market entry of biosimilars expected to lower prices significantly.
• Competitive pressure could drive prices down by up to 50%, aligning with biosimilar trends in other biologics.
• Market share may diffuse among multiple players, impacting pricing power.

Key Regulatory and Policy Factors

• Patent exclusivity: Patent for Rylaze extends through at least 2030.
• Therapy reimbursement policies: Medicare, Medicaid, and private payers influence net prices; prior authorization and step therapy could restrict early access.
• Biosimilar pathway: The FDA's approval of biosimilars could affect pricing dynamics after patent expiration; no biosimilar approvals for Rylaze as of yet.

Risks to Price Stability

• Introduction of biosimilar competitors.
• Policy shifts toward price regulation.
• Uptake delays due to clinical practice inertia or payer resistance.

Summary

Aspect	Observation
Market Size	Approximately $900 million in the U.S. in 2022
Current Pricing	$63,000–$69,000 per vial
Competition	Elspar, Oncaspar, biosimilars (future prospects)
Price Projection (2-5 years)	Potential 20-30% reduction post-biosimilar entry

Key Takeaways

• Rylaze holds a strategic position in the pediatric ALL treatment market due to its recombinant, low-immunogenic profile.
• Prices are high, driven by manufacturing complexity and limited competition.
• Long-term pricing will decline with biosimilar development, regulatory changes, and market penetration.
• Current exclusivity and patent protections support stable pricing in the near term.
• Payers and policies will influence access and reimbursement, shaping price trajectories.

FAQs

1. When will biosimilars for Rylaze arrive in the market?
   No biosimilar has received FDA approval as of 2023. Approval timelines depend on biosimilar developers and FDA review processes, typically 3–5 years post-patent expiry.

2. How do Rylaze’s prices compare globally?
   International prices tend to be lower due to different healthcare systems and negotiated discounts; U.S. prices are among the highest.

3. What impact will insurance have on actual patient costs?
   Reimbursement policies and prior authorization may limit patient access or result in high out-of-pocket expenses despite high list prices.

4. Are there ongoing efforts to reduce manufacturing costs?
   Yes, as demand increases and biosimilars reduce costs, manufacturing efficiencies are expected to lower production expenses.

5. How does Rylaze’s market share compare to older formulations?
   Rylaze's adoption is growing, but it remains limited to specific indications and patient populations, with older formulations still prevalent in off-label or less safety-sensitive scenarios.

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References

[1] Food and Drug Administration. (2021). Rylaze (asparaginase erwinia chrysanthemi). Retrieved from https://www.fda.gov

[2] IQVIA. (2022). Oncology Market Reports. IQVIA Institute for Human Data Science.

[3] EvaluatePharma. (2023). Biotech & Biosimilar Market Trends. Evaluate Ltd.

[4] U.S. Department of Health & Human Services. (2022). Drug pricing and reimbursement policies.