Last updated: February 14, 2026
What is the current market status and pricing for NDC 42543-0497?
NDC 42543-0497 is a brand-name drug marketed under PenG (Benzylpenicillin) Injection, 1 million units (MU), primarily used for bacterial infections, including Streptococcus pneumoniae and syphilis. Its manufacturing company is Pfizer, and it is available in hospital and outpatient settings.
Market Overview
Demand Dynamics
- The demand for Benzylpenicillin has declined over the last decade, driven by the rise of oral and broad-spectrum antibiotics, and concerns over resistance.
- However, PenG retains importance in specific clinical situations—including neurosyphilis, certain resistant infections, and allergy management—maintaining some steady clinical demand.
- The drug's usage is concentrated in hospitals and clinics with infectious disease specialties.
Regulatory Landscape
- FDA approval for PenG remains stable; no recent label updates flag widespread shortages or restrictions.
- Recent efforts focus on antimicrobial stewardship to optimize injection use, reducing overprescription.
Supply Factors
- The manufacturing landscape has consolidated; Pfizer and a handful of sterile injectables producers control supply.
- Supply chain disruptions have occasionally affected availability, notably during the COVID-19 pandemic.
Pricing Analysis
Current Wholesale Acquisition Cost (WAC)
- The average WAC for PenG 1 MU injections currently ranges from $2.00 to $3.50 per vial (source: MCC, First Databank, Red Book 2023).
- Actual hospital procurement prices can be significantly lower, with price discounts ranging from 10% to 35% based on volume and contractual arrangements.
Historical Price Trends
- The price has remained relatively stable over five years, with small fluctuations.
- No significant price hikes have occurred recently, contrasting with other antibiotics subjected to shortages or shortages-driven increases.
Pricing Projections
- For the next 12-24 months, expect minimal volatility barring supply chain disruptions.
- Prices may fluctuate slightly due to inflation, procurement negotiations, or changes in antimicrobial stewardship policies.
- If regulatory policies tighten or shortages develop, prices could rise temporarily by 10-20%.
Market Drivers Affecting Future Pricing
| Driver |
Effect |
Source/Notes |
| Antibiotic Resistance |
Maintains niche demand |
CDC, 2022 |
| Supply Chain Stability |
Price stability |
Industry reports, 2023 |
| Regulatory Policies |
Potential price impact |
FDA updates, antimicrobial stewardship initiatives |
| Competition |
Limited, mainly Pfizer |
Market exclusivity in specific indications |
Competitive Landscape
- Few FDA-approved competitors for injectable Benzylpenicillin in the US, primarily limited to compounded forms or generics from other manufacturers.
- The lack of direct generic competition in US hospitals sustains relatively stable pricing.
Conclusions
- Current market value: WAC around $2–$3.50 per vial.
- Supply stability: Healthy but susceptible to disruptions.
- Pricing outlook: Stable with potential minor increases aligned with inflation and supply factors over the next two years.
Key Takeaways
- NDC 42543-0497 (Benzylpenicillin injection) has a niche but consistent demand driven by specific clinical uses.
- Prices hover within a narrow range, with no recent significant increases.
- Future pricing remains stable unless supply disruptions or regulatory changes occur.
FAQs
1. Is PenG available in generic form?
Yes, several manufacturers produce generic benzylpenicillin injectable formulations. However, Pfizer's branded form remains a significant market player.
2. What factors could cause Price fluctuations for NDC 42543-0497?
Potential causes include supply shortages, increased regulatory restrictions, or changes in antimicrobial stewardship policies that influence demand.
3. How does PenG compare in price to other antibiotics?
PenG is relatively inexpensive compared to broad-spectrum antibiotics; typical costs are under $4 per vial, making it one of the lower-cost injectables.
4. Are there patent protections or exclusivity policies affecting PenG prices?
No. PenG has long been off patent, and no exclusivity periods are currently in effect, contributing to price stability.
5. What industries or sectors are the main consumers of PenG?
Hospitals, outpatient clinics, and infectious disease specialty practices use PenG for specific indications requiring injectable penicillin therapy.
References
- First Databank. Antibiotic pricing data, 2023.
- Red Book. 2023. Pharmaceutical pricing and supply updates.
- Centers for Disease Control and Prevention. Antibiotic resistance threats, 2022.
- FDA. Drug approvals and labeling information, 2023.
- Industry reports on antimicrobial supply chains, 2023.
