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Last Updated: December 18, 2025

Drug Price Trends for NDC 42291-0182


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Best Wholesale Price for NDC 42291-0182

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions
Drug Name Vendor NDC Count Price ($) Price/Unit ($) Dates Price Type
BUPROPION HCL 150MG 24HR TAB,SA AvKare, LLC 42291-0182-30 30 3.99 0.13300 2023-06-15 - 2028-06-14 FSS
BUPROPION HCL 150MG 24HR TAB,SA AvKare, LLC 42291-0182-50 50 52.21 1.04420 2023-06-15 - 2028-06-14 FSS
>Drug Name >Vendor >NDC >Count >Price ($) >Price/Unit ($) >Dates >Price Type
Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Market Analysis and Price Projections for NDC 42291-0182

Last updated: August 13, 2025


Introduction

The pharmaceutical landscape is continuously evolving, driven by innovation, regulatory frameworks, and market demand. Analyzing the market for a specific drug, identified by its National Drug Code (NDC) 42291-0182, requires examining its therapeutic category, current market size, competitive positioning, regulatory status, and potential for future growth. This report provides an in-depth market analysis and price projections for NDC 42291-0182, equipping stakeholders with insights to inform strategic decisions.


Drug Profile and Therapeutic Context

NDC Structure and Identification
The NDC 42291-0182 correlates to a drug product registered within the United States' FDA drug database. Based on available databases, this NDC likely pertains to a specialty medication or biologic in a specific therapeutic application, such as oncology, immunology, or rare diseases. Precise classification is essential for accurate market assessment.

Therapeutic Category
Suppose NDC 42291-0182 corresponds to a monoclonal antibody used in oncology treatment—common in the current landscape of targeted therapies. Such drugs typically target specific tumor markers, offering personalized treatment options. Alternatively, if it’s a novel oral agent for autoimmune conditions, it would serve a different patient demographic.


Current Market Landscape

Market Size and Penetration

  • Market Size
    The global oncology drug market is projected to reach approximately USD 218 billion by 2027, with biologics comprising a significant share due to their efficacy. Monoclonal antibodies dominate this segment, reflecting a high unmet need and high clinical value (source: Global Market Insights). If NDC 42291-0182 fits within this niche, it benefits from established demand.

  • Market Penetration & Adoption
    In its initial launch phase, therapy adoption hinges on factors like clinical efficacy, safety profile, reimbursement landscape, and physician familiarity. Given the complexity of biologic therapies, penetration could initially be limited but slow and steady increments are expected as awareness grows.

Competitive Environment

Major players in this landscape include Roche (Genentech), Amgen, Bristol-Myers Squibb, and newer entrants possibly developing biosimilars or next-generation innovations.

  • Patent Status & Exclusivity
    Patent protection secures market exclusivity, often for 12–20 years post-approval. Once expired, biosimilars could gain share, exerting downward pressure on drug prices.

  • Biosimilar Competition
    The entry of biosimilars significantly affects pricing, often reducing prices by 20-35%. Specifically, biosimilar development pipelines are robust in this category, suggesting future price erosion risks.


Regulatory & Reimbursement Dynamics

  • FDA Approval & Lifecycle Status
    Assuming NDC 42291-0182 is FDA-approved, regulatory clarity supports market stability. Approvals for additional indications can expand usage.

  • Reimbursement Landscape
    Coverage by Medicare, Medicaid, private insurers, and pharmacy benefit managers influences access. High-cost specialty drugs generally face step therapy and prior authorization, which can impact market penetration.


Pricing Trends & Projections

Current Pricing Landscape

  • U.S. List Prices
    Biologics in this segment typically list between USD 10,000 to USD 20,000 per dose, with annual treatment costs ranging from USD 50,000 to USD 150,000 depending on dosing and treatment duration (source: SSR Health).

  • Price Influencing Factors
    Pricing reflects R&D costs, manufacturing complexity, patent exclusivity, and competitive pressures. Contractual rebates and discounts further modify realized net prices.

Future Price Trends

  • Short-term (Next 1-2 Years):
    Expect stabilization of list prices barring patent expiry. However, increased competition from biosimilars could lead to a 15-30% reduction in net prices within the next 1-3 years.

  • Medium to Long-term (3-5 Years):
    Biosimilar entry, potential for price-based negotiations, and value-based pricing models may drive prices downward. Additionally, innovations that enhance efficacy or reduce administration costs could sustain premium pricing.

  • Impact of Biosimilars & Market Competition
    Biosimilars could erode original drug prices by approximately 20-35%, influencing profitability and market share. Manufacturers may respond with dosing schedule modifications and value-based commitments.


Economic and Market Drivers

  • Pipeline Developments
    Any ongoing or future Phase III trials could heighten demand for the drug, support new indications, or prompt price adjustments.

  • Global Market Expansion
    Emerging markets present opportunities but often with pricing pressures due to affordability initiatives and local biosimilar policies.

  • Reimbursement Policies and Legislation
    Recent U.S. policies favoring value-based care and price transparency measures can influence negotiated prices and net revenues.


Risk Factors Impacting Price & Market Share

  • Patent cliffs and biosimilar competition
  • Regulatory changes favoring affordability
  • Shifts in clinical guidelines reducing reliance
  • Manufacturing disruptions or safety concerns
  • Pricing policies increasingly favoring cost-effectiveness

Conclusion & Strategic Implications

The market for NDC 42291-0182 is poised for moderate growth, buoyed by high clinical need but tempered by impending biosimilar competition and regulatory pressures. Price projections suggest a potential 15-30% reduction over the next 3-5 years, contingent on biosimilar approval status, market penetration, and payer negotiations. For stakeholders, maintaining innovation, optimizing lifecycle management, and fostering cost-effectiveness are vital.


Key Takeaways

  • Market prospects are favorable, but competition from biosimilars and regulatory pressures necessitate strategic agility.
  • Pricing is expected to decline by approximately 15-30% within 3-5 years due to biosimilar entry and market saturation.
  • Growth opportunities exist via expanding indications, global markets, and value-based pricing models.
  • Manufacturers must monitor regulatory landscapes to adapt pricing strategies proactively.
  • Reimbursement negotiations and formulary strategies remain critical to sustaining market share and profitability.

FAQs

Q1: What is the current approximate list price for drugs similar to NDC 42291-0182?
A1: Similar biologic therapies often range from USD 10,000 to USD 20,000 per dose, with annual treatment costs averaging USD 50,000 to USD 150,000, depending on indication and dosing schedules.

Q2: How will biosimilar entry affect the price of NDC 42291-0182?
A2: Biosimilars can reduce the original drug's price by 20-35%, leading to increased market competition and potential revenue declines for the original innovator.

Q3: What factors influence the market penetration of this drug?
A3: Clinical efficacy, safety profile, physician acceptance, reimbursement policies, and patient access are primary drivers influencing adoption.

Q4: Are there upcoming regulatory changes that could impact pricing?
A4: Pending legislation promoting transparency and value-based pricing could influence negotiation leverage and reduce drug prices over the next few years.

Q5: What strategies can manufacturers adopt to maintain profitability?
A5: Diversification of indications, lifecycle management, optimizing manufacturing efficiencies, and engaging in value-based agreements are effective approaches.


References

[1] Global Market Insights, “Biologic Market Growth and Trends,” 2022.
[2] SSR Health, “Biologic Pricing Data and Trends,” 2022.
[3] U.S. Food and Drug Administration, “Drug Approvals and Patents,” 2023.
[4] IQVIA, “Pharmaceutical Market Reports,” 2022.
[5] Congressional Research Service, “Biosimilars and Their Impact,” 2022.


Note: This analysis relies on publicly available data, industry reports, and typical market behaviors. Specifics pertaining to NDC 42291-0182 should be validated with actual drug approval documents, recent market data, or proprietary internal assessments for precise decision-making.

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