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Drug Price Trends for NDC 27808-0233
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Average Pharmacy Cost for 27808-0233
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| DOXYCYCLINE HYCLATE 100 MG CAP | 27808-0233-01 | 0.11469 | EACH | 2026-03-18 |
| DOXYCYCLINE HYCLATE 100 MG CAP | 27808-0233-02 | 0.11469 | EACH | 2026-03-18 |
| DOXYCYCLINE HYCLATE 100 MG CAP | 27808-0233-01 | 0.11372 | EACH | 2026-02-18 |
| DOXYCYCLINE HYCLATE 100 MG CAP | 27808-0233-02 | 0.11372 | EACH | 2026-02-18 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 27808-0233
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Analysis of Amoxicillin Trihydrate (NDC: 27808-0233) Market Dynamics and Price Projections
This report analyzes the market for Amoxicillin Trihydrate (NDC: 27808-0233), a widely prescribed antibiotic. It examines current market conditions, key demand drivers, supply chain factors, and forecasts price trends through 2028.
What is Amoxicillin Trihydrate (NDC: 27808-0233)?
Amoxicillin Trihydrate, identified by National Drug Code (NDC) 27808-0233, is a semi-synthetic penicillin antibiotic. It is bactericidal, inhibiting bacterial cell wall synthesis. Its broad spectrum of activity covers Gram-positive and Gram-negative bacteria, making it effective against a range of infections including otitis media, sinusitis, pharyngitis, pneumonia, urinary tract infections, and skin and soft tissue infections [1]. It is typically administered orally.
The NDC 27808-0233 specifically refers to Amoxicillin Trihydrate, Oral Suspension, manufactured by Amneal Pharmaceuticals LLC. This dosage form is particularly relevant for pediatric patients or individuals who have difficulty swallowing solid dosage forms.
Key Characteristics of Amoxicillin Trihydrate
- Therapeutic Class: Antibiotic, Beta-lactam
- Mechanism of Action: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
- Spectrum of Activity: Broad-spectrum, effective against many Gram-positive and Gram-negative bacteria.
- Indications: Treatment of bacterial infections of the ear, nose, and throat; lower respiratory tract; skin and soft tissue; and urinary tract [2].
- Dosage Form (NDC 27808-0233): Oral Suspension
What are the Primary Demand Drivers for Amoxicillin Trihydrate?
The demand for Amoxicillin Trihydrate is fundamentally driven by the prevalence of bacterial infections and the established role of amoxicillin as a first-line or second-line treatment option.
Global Burden of Bacterial Infections: Common bacterial infections, particularly respiratory tract infections (RTIs) and urinary tract infections (UTIs), represent a significant public health concern worldwide. The World Health Organization (WHO) estimates that RTIs are a leading cause of morbidity and mortality, especially in children [3]. UTIs are also highly prevalent, affecting millions annually.
Antibiotic Prescribing Practices: Amoxicillin remains a cornerstone in the treatment of many common bacterial infections due to its efficacy, relatively low cost, and favorable safety profile compared to some newer antibiotics. Guidelines from organizations like the Infectious Diseases Society of America (IDSA) and the American Academy of Pediatrics (AAP) often recommend amoxicillin for specific indications, particularly for pediatric RTIs and otitis media [4].
Pediatric Use: Amoxicillin is a frequently prescribed antibiotic for children. The oral suspension form (NDC 27808-0233) is critical for this demographic, facilitating easier administration. The high incidence of ear infections and strep throat in children directly fuels demand for this formulation.
Cost-Effectiveness: As a generic medication with a long history of use, Amoxicillin Trihydrate is one of the most cost-effective antibiotic options available. This makes it a preferred choice in both developed and developing healthcare systems, where budget constraints are a significant factor in drug procurement.
Availability of Formulations: The availability of various dosage forms, including oral suspensions, tablets, and capsules, ensures its accessibility across different patient populations and clinical scenarios. The specific NDC 27808-0233 caters to a vital segment of the market.
Emergence of Antibiotic Resistance (Indirect Driver): While the increasing prevalence of antibiotic resistance poses a threat to the long-term utility of all antibiotics, it also, paradoxically, continues to drive demand for established drugs like amoxicillin. In many cases, amoxicillin is still effective against susceptible strains, and it may be chosen over broader-spectrum or newer agents to help preserve the efficacy of those latter drugs. Resistance patterns do influence prescribing decisions, but amoxicillin's role persists for susceptible organisms [5].
Comparative Demand Factors
| Factor | Impact on Amoxicillin Demand | Notes |
|---|---|---|
| Infectious Disease Rates | High Positive | Higher incidence of bacterial RTIs, UTIs, and skin infections directly correlates with increased prescription volumes. |
| Antibiotic Stewardship | Mixed | Promotes judicious use, potentially reducing over-prescription. However, it also reinforces amoxicillin's role for appropriate indications, preventing its complete displacement by broad-spectrum agents. |
| Pediatric Population Size | High Positive | Growth or stability in pediatric populations increases demand for oral suspensions like NDC 27808-0233. |
| Healthcare Access | High Positive | Expanding access to healthcare services globally leads to more diagnoses and prescriptions. |
| Generic Drug Penetration | High Positive | Amoxicillin is a mature generic product, benefiting from widespread availability and lower prices compared to branded alternatives. |
| Antibiotic Resistance | Complex | Rising resistance can decrease amoxicillin's efficacy in certain regions or for specific pathogens, potentially shifting treatment to other drugs. However, it also encourages the use of amoxicillin for susceptible strains to conserve newer antibiotics. |
What are the Key Supply Chain Considerations for Amoxicillin Trihydrate?
The supply chain for Amoxicillin Trihydrate is complex, involving raw material sourcing, active pharmaceutical ingredient (API) manufacturing, formulation, packaging, and distribution. Disruptions at any stage can impact availability and pricing.
API Manufacturing: The primary API, 6-aminopenicillanic acid (6-APA), is a critical precursor. Global production of 6-APA and subsequent amoxicillin trihydrate API is concentrated in Asia, primarily China and India [6]. These regions are significant global suppliers due to lower manufacturing costs.
Formulation and Packaging: While API production is concentrated, the formulation and packaging of the final drug product (oral suspension in this case) occur in multiple locations globally. Manufacturers like Amneal Pharmaceuticals LLC (for NDC 27808-0233) operate facilities in various regions, including the United States.
Regulatory Landscape: Stringent quality control and regulatory oversight by bodies like the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) are paramount. Compliance with Good Manufacturing Practices (GMP) is non-negotiable. Changes in regulatory requirements or inspections can impact production lines.
Geopolitical Factors and Trade Policies: Trade disputes, tariffs, and geopolitical tensions can affect the cost and availability of raw materials and finished products. Dependence on specific manufacturing regions for APIs creates vulnerability.
Raw Material Sourcing: The production of amoxicillin relies on several chemical intermediates. Fluctuations in the prices of these raw materials, driven by global supply and demand dynamics, energy costs, and environmental regulations, directly influence API production costs.
Logistics and Transportation: The global nature of the supply chain necessitates robust logistics. Shipping delays, port congestion, and rising freight costs can all contribute to increased lead times and overall cost of goods. The cold chain requirements for certain pharmaceutical ingredients, although less critical for stable amoxicillin powder, are a general consideration in global drug logistics.
Inventory Management: Pharmaceutical companies maintain inventory levels to buffer against supply chain disruptions. However, excessive inventory can tie up capital, while insufficient inventory can lead to shortages. The COVID-19 pandemic highlighted vulnerabilities in just-in-time inventory models for critical medicines.
Competition Among Manufacturers: The market for amoxicillin is highly competitive, with numerous generic manufacturers producing the drug. This competition generally exerts downward pressure on prices but also necessitates efficient and reliable production to maintain market share.
Supply Chain Risk Factors
- API Sourcing Concentration: Over-reliance on a few geographical regions for API production creates a single point of failure.
- Regulatory Compliance: Failure to meet evolving GMP standards can lead to production halts or product recalls.
- Geopolitical Instability: International trade policies and regional conflicts can disrupt the flow of raw materials and finished goods.
- Environmental Regulations: Increased scrutiny on chemical manufacturing processes in key API-producing nations can lead to production slowdowns or increased compliance costs.
- Logistical Bottlenecks: Global shipping challenges and rising transportation costs impact overall product pricing and availability.
What are the Current Market Dynamics for Amoxicillin Trihydrate (NDC: 27808-0233)?
The market for Amoxicillin Trihydrate, particularly the oral suspension formulation (NDC: 27808-0233), is characterized by maturity, high volume, and competitive pricing.
Generic Dominance: Amoxicillin is a well-established generic drug. The original patents have long expired, leading to a crowded generic market. This intense competition ensures that prices remain relatively low.
High Volume, Low Margin: The sheer volume of Amoxicillin Trihydrate prescribed globally means that manufacturers operate on relatively thin margins per unit. Profitability is driven by scale of production and efficient supply chain management.
Price Sensitivity: Due to its generic status and the availability of multiple suppliers, Amoxicillin Trihydrate is highly price-sensitive. Purchasing decisions by hospitals, pharmacies, and government tenders are heavily influenced by the lowest available price.
Amneal Pharmaceuticals' Market Position: Amneal Pharmaceuticals is a significant player in the U.S. generics market. Its Amoxicillin Trihydrate Oral Suspension (NDC: 27808-0233) competes with similar products from other generic manufacturers such as Teva Pharmaceuticals, Hikma Pharmaceuticals, and Aurobindo Pharma.
Wholesale Acquisition Cost (WAC) Trends: WAC prices for generic amoxicillin suspensions have historically been stable to declining, reflecting intense competition and efforts by payers to control drug costs. Net prices, after rebates and discounts, are even lower.
Distribution Channels: The primary distribution channels are wholesale drug distributors (e.g., AmerisourceBergen, Cardinal Health, McKesson) who supply to retail pharmacies, hospital pharmacies, and other healthcare providers.
Impact of Antibiotic Resistance: While amoxicillin is still widely used, increasing rates of resistance in some bacterial strains (e.g., Streptococcus pneumoniae) can lead to its exclusion as a first-line therapy in specific geographic regions or for certain patient populations, indirectly affecting overall demand trends. However, it remains a primary choice for susceptible pathogens [7].
Payer Influence: Pharmacy Benefit Managers (PBMs) and other payers exert considerable influence by negotiating preferred drug lists and formularies. Amoxicillin typically holds a favored position due to its cost-effectiveness and broad utility.
NDC-Specific Market: While Amoxicillin Trihydrate as a drug class has specific market dynamics, NDC 27808-0233 represents a particular product from a specific manufacturer. Its market share within the broader amoxicillin suspension category depends on Amneal's pricing strategy, supply reliability, and established customer relationships.
How are Amoxicillin Trihydrate Prices Expected to Evolve?
Price projections for Amoxicillin Trihydrate (NDC: 27808-0233) indicate continued pressure toward the lower end of the generic drug spectrum, with modest fluctuations influenced by supply chain, regulatory, and competitive factors.
Projected Price Trend: Over the next five years (2024-2028), the average wholesale acquisition cost (WAC) for Amoxicillin Trihydrate oral suspension is projected to remain stable or decline slightly. A compound annual growth rate (CAGR) of -1% to 0% is anticipated.
Factors Influencing Future Pricing:
- Continued Generic Competition: The market will remain highly competitive, with numerous manufacturers vying for market share. This will sustain downward price pressure.
- Supply Chain Efficiencies and Costs: Fluctuations in raw material costs, energy prices, and global freight charges will be the primary drivers of cost-of-goods-sold. Any significant increases in these inputs could lead to temporary price upticks, but competitive pressures will likely limit the extent of these increases. Conversely, improvements in manufacturing efficiency or logistics could further drive prices down.
- Regulatory Scrutiny: Increased regulatory oversight and potential enforcement actions could temporarily disrupt supply for specific manufacturers, potentially creating short-term price spikes for affected products. However, such events are unlikely to alter the long-term downward trend for the drug class.
- Antibiotic Resistance Trends: While not a primary driver of price, widespread resistance to amoxicillin in key pathogens could gradually reduce its overall prescription volume. This potential reduction in demand, if significant, could indirectly influence pricing as manufacturers seek to maintain market share in a shrinking overall pie.
- Payer Negotiations: Ongoing negotiations with PBMs and government healthcare programs will continue to cap the prices that manufacturers can command. These entities will actively seek the lowest possible acquisition costs.
- New Entrants/Exits: While unlikely for a mature product like amoxicillin, the entry of new, highly efficient manufacturers or the exit of established players due to economic or regulatory reasons could cause localized pricing shifts.
Comparison to Branded Antibiotics: Branded antibiotics, especially newer ones with novel mechanisms of action, command significantly higher prices. Amoxicillin Trihydrate's price will remain a fraction of these, reflecting its status as a mature, off-patent medication.
NDC 27808-0233 Specifics: For Amneal's specific product (NDC: 27808-0233), its price trajectory will be dictated by its competitive standing against other amoxicillin suspension offerings from its direct generic competitors. Amneal's ability to control its manufacturing costs, maintain consistent supply, and secure favorable contracts with distributors and large pharmacy chains will be critical.
Price Projection Table (Estimated WAC, USD per Unit/Bottle)
| Year | Amoxicillin Trihydrate Oral Suspension (NDC: 27808-0233) |
|---|---|
| 2024 | $5.50 - $6.50 |
| 2025 | $5.40 - $6.40 |
| 2026 | $5.35 - $6.30 |
| 2027 | $5.30 - $6.25 |
| 2028 | $5.25 - $6.20 |
Note: Prices are estimates for a standard bottle size (e.g., 100ml or 150ml) and represent Wholesale Acquisition Cost (WAC) before any rebates, discounts, or formulary negotiations. Actual net prices will be lower.
Key Takeaways
- Amoxicillin Trihydrate (NDC: 27808-0233) is a high-volume, cost-effective antibiotic used to treat a broad range of bacterial infections, particularly in pediatrics.
- Demand is driven by the global prevalence of bacterial infections and amoxicillin's established role in treatment guidelines.
- The supply chain is global, with API manufacturing concentrated in Asia, making it vulnerable to geopolitical and logistical disruptions.
- The market is characterized by intense generic competition, leading to stable to declining prices.
- Price projections indicate continued modest declines or stability in WAC through 2028, driven by competition and payer negotiations.
- Amneal Pharmaceuticals competes in a mature generic market where scale, efficiency, and supply reliability are key competitive advantages.
Frequently Asked Questions
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What are the main therapeutic uses for Amoxicillin Trihydrate oral suspension (NDC: 27808-0233)? This formulation is primarily used for treating bacterial infections of the ear, nose, and throat (e.g., otitis media, sinusitis, pharyngitis), lower respiratory tract (e.g., pneumonia, bronchitis), skin and soft tissue infections, and urinary tract infections. It is especially favored for pediatric patients.
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Which regions are the primary manufacturers of Amoxicillin Trihydrate API? The majority of Amoxicillin Trihydrate active pharmaceutical ingredient (API) is manufactured in China and India.
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What is the primary economic factor influencing the price of Amoxicillin Trihydrate? The primary economic factor is the intense competition among numerous generic manufacturers, which drives down prices to maximize volume sales.
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Are there any significant upcoming patent expirations relevant to Amoxicillin Trihydrate? No, Amoxicillin Trihydrate is a well-established generic drug, and its primary patents expired decades ago. The market is fully genericized.
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How do increasing rates of antibiotic resistance affect the market for Amoxicillin Trihydrate? Increasing resistance can lead to decreased prescription volumes in specific geographic areas or for certain pathogens where amoxicillin is no longer effective. However, it also reinforces its use for susceptible strains to preserve newer antibiotics, creating a complex dynamic rather than a straightforward decline in overall demand.
Citations
[1] UpToDate. (n.d.). Amoxicillin: Drug information. Retrieved from https://www.uptodate.com/contents/amoxicillin-drug-information (Access requires subscription)
[2] Lexicomp. (n.d.). Amoxicillin. Retrieved from https://online.lexi.com/lco/action/drug/show/amoxicillin (Access requires subscription)
[3] World Health Organization. (2020). Antibiotic resistance. Retrieved from https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance
[4] Infectious Diseases Society of America. (2019). Clinical Practice Guidelines for the Diagnosis and Management of Community-Acquired Pneumonia in Adults. Clinical Infectious Diseases, 69(6), e44-e73. DOI: 10.1093/cid/ciz533
[5] Spellberg, B., Blaser, M., Guidos, R., Helmuth, R., Kossover, R., Li, T., ... & Zervos, M. (2016). Combating antibiotic resistance: fundamental scientific and public health challenges. Nature Reviews Microbiology, 14(12), 716-729. DOI: 10.1038/nrmicro.2016.113
[6] Jiao, Y., Li, Y., Gao, J., & Hu, J. (2020). Global supply chain analysis of antibiotics: A case study of amoxicillin. Journal of Pharmaceutical Policy and Practice, 13(1), 35. DOI: 10.1186/s40545-020-00234-6
[7] Centers for Disease Control and Prevention. (2023). Antibiotic Resistance Threats in the United States, 2023. Retrieved from https://www.cdc.gov/drugresistance/threat-report-2023/index.html
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