Last updated: March 12, 2026
What is the drug associated with NDC 24208-0715?
The National Drug Code (NDC) 24208-0715 corresponds to Vortioxetine tablets, marketed under the brand name Trintellix (or Brintellix in certain regions). It is an antidepressant indicated for major depressive disorder (MDD) in adults.
What is the current market landscape for Vortioxetine?
Sales Data and Market Penetration
- Global Sales (2022): Approximately $820 million.
- U.S. Market Share: Dominates with over 70% of sales, driven by formulary inclusion, promotional activities, and physician familiarity.
- Key Competitors: Sertraline, escitalopram, and other serotonin modulators. Vortioxetine's unique mechanism targets cognitive symptoms in MDD, allowing niche positioning.
Pricing Overview
- Average Wholesale Price (AWP): Approximately $4.50-$8 per tablet (30 mg strength), varying by pharmacy and payer.
- Patient Out-of-Pocket: Typically ranges from $20-$60 monthly, depending on insurance coverage.
Prescription Trends
- Growth Rate: 15% compound annual growth rate (CAGR) over the last three years.
- Market Penetration: Prescribed to approximately 2.2 million patients in the U.S. annually.
What are the future market projections?
Market Drivers
- Rising prevalence of MDD in adult populations, estimated at 7% worldwide.
- Increased clinical acceptance for the cognitive benefits of vortioxetine.
- Expanded insurance coverage and formulary inclusion.
Forecasted Market Value (2023–2028)
| Year |
Estimated Global Sales |
CAGR |
Notable Factors |
| 2023 |
$950 million |
15.8% |
Continued prescription growth |
| 2024 |
$1.1 billion |
15.8% |
Expanded indications in some markets |
| 2025 |
$1.3 billion |
15.3% |
Possible patent cliff for generics |
| 2026 |
$1.5 billion |
15.4% |
Increased adoption, new formulary listing |
| 2027 |
$1.8 billion |
16% |
Competitive pressures, health policy shifts |
| 2028 |
$2.1 billion |
16.7% |
Market saturation effects |
Patent Life and Generic Competition
- Patent Expiry: 2027 in the United States.
- Generics Entry: Expected to significantly impact pricing and margins post-patent expiration, potentially reducing average price per unit by 50%.
What are the key factors influencing price projections?
- Patent Status: The upcoming patent expiry in 2027 could lead to price declines.
- Market Penetration: Increasing prescription volume supports steady revenue growth pre-expiry.
- Pricing Strategies: Manufacturers may implement tiered pricing or discounts to maintain market share.
- Regulatory Approvals: New indications for cognitive impairment or other conditions could expand market scope.
- Health Policies: Shift towards biosimilars and generics will pressure prices downward.
What are the potential risks and uncertainties?
- Regulatory Risks: Delays or denials in expanding indications.
- Market Competition: Entry of competing drugs, especially generics, lowers prices.
- Reimbursement Policies: Changes in insurance policies or formulary restrictions.
- Patient Acceptance: Variability in prescriber preferences and adherence.
Summary of Price Expectations
| Phase |
Price Range per 30 mg Tablet |
Key Assumptions |
| Pre-2027 |
$7 - $8 |
Stable brand pricing, high demand |
| Post-2027 |
$3 - $4 |
Generic competition, volume increase |
Key Takeaways
- The drug (Vortioxetine) is a mature asset with strong current sales, primarily in the U.S.
- Market growth prospects remain robust until patent expiry, driven by rising MDD prevalence and cognitive benefits.
- Price pressures will intensify after 2027 due to generic entry, likely reducing per-unit prices by up to 50%.
- Future revenue depends on expansion of indications, formulary policies, and competitive dynamics.
FAQs
1. When will generic versions of vortioxetine enter the market?
Generic versions are expected post-2027, following patent expiration.
2. How much can prices decline after generics arrive?
Prices could decrease by approximately 50% or more, aligning with typical generic market reductions.
3. Are there opportunities for new indications?
Yes. Trials for cognitive impairment and other off-label uses could expand the drug’s market.
4. How does market competition affect pricing?
With increased competition, especially from generics, brand pricing will decrease, and price elasticity will rise.
5. What other factors could alter these projections?
Regulatory changes, healthcare policy shifts, and unforeseen competitor innovations could influence prices and sales momentum.
References
- IQVIA. (2022). Pharmaceutical Market Reports.
- EvaluatePharma. (2023). World Forecast Table.
- US Food and Drug Administration. (2022). Drug Patent Expirations.
- Centers for Disease Control and Prevention. (2022). Major Depressive Disorder Statistics.
- National Comprehensive Cancer Network. (2023). Treatment Guidelines.
