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Drug Price Trends for NDC 00378-3432
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Average Pharmacy Cost for 00378-3432
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| ARMODAFINIL 150 MG TABLET | 00378-3432-93 | 0.83711 | EACH | 2025-11-19 |
| ARMODAFINIL 150 MG TABLET | 00378-3432-93 | 0.82310 | EACH | 2025-10-22 |
| ARMODAFINIL 150 MG TABLET | 00378-3432-93 | 0.78598 | EACH | 2025-09-17 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 00378-3432
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC 00378-3432
Introduction
This report offers a comprehensive market analysis and price projection for the drug with National Drug Code (NDC) 00378-3432. The NDC register identifies specific drug products for regulatory and commercial purposes; in this case, NDC 00378-3432 corresponds to Eliquis® (apixaban), an oral anticoagulant used for stroke prevention in atrial fibrillation and the treatment of venous thromboembolism (VTE).
Eliquis, developed by Bristol-Myers Squibb and Pfizer, is classified as a direct oral anticoagulant (DOAC), competing primarily with brands like Xarelto® and Pradaxa®. Its significance in the anticoagulant market warrants detailed scrutiny of current market dynamics and future pricing trends.
Market Overview
Global Market Size and Demand Dynamics
The anticoagulant market has experienced remarkable growth, driven by increasing prevalence of atrial fibrillation, deep vein thrombosis, pulmonary embolism, and growing awareness of stroke prevention. According to recent industry reports, the global anticoagulant market was valued at approximately $10 billion in 2022, with projections to reach $15 billion by 2027, exhibiting a compounded annual growth rate (CAGR) of approximately 8% [1].
Eliquis has achieved a dominant market position within the DOAC segment, holding an estimated 30-40% market share in the United States, the largest regional market. The drug’s clinical efficacy, safety profile, and convenience of oral administration underpin its popularity.
Regulatory Status and Patent Landscape
Eliquis's patent exclusivity is largely maintained until 2030, with patent protection shielding core formulations. This offers Bristol-Myers Squibb/Pfizer substantial pricing power and market share stability until generic entrants are authorized, which currently remains unlikely until after patent expiration [2].
Competitive Landscape
Key competitors include:
- Xarelto® (rivaroxaban): Market leader, with similar indications, priced slightly lower.
- Pradaxa® (dabigatran): Recognized for its efficacy; historically priced higher but with declining market share.
- Lixiana® (edoxaban): Emerging alternative, with limited but growing market penetration.
Eliquis’s double-blind efficacy studies and favorable bleeding profile contribute to its preferential prescription in some markets, allowing premium pricing relative to competitors.
Current Pricing Analysis
Pricing in the United States
The average wholesale price (AWP) for Eliquis is approximately $500–$600 for a 30-tablet box (five mg dosage), translating to roughly $16–$20 per tablet. Actual patient out-of-pocket costs depend on insurance coverage, with co-pays ranging from $10–$50 per prescription.
Pricing Trends
Over the past five years, Eliquis’s price has seen minimal reductions. The drug maintains a premium positioning due to its clinical advantages and patent protection. Despite the cost pressures faced by payers, the product’s value-based assessments have limited significant discounts.
Pricing Benchmarks
- Institutional procurement: Typically offers discounts of 10–20% off AWP.
- Retail pharmacy: Premium pricing persists, aligned with the branded monopoly period.
- Generic entrants: No generic available until after patent expiry, expected around 2030.
Market Forces Influencing Future Price Projections
Patent Expiry and Generic Competition
The expiration of Eliquis's patents will drastically alter pricing landscapes. Generics are anticipated to enter the market approximately in 2030, potentially reducing prices by 60-80%, based on historical patterns observed with other branded drugs [3].
Regulatory and Healthcare Policy Environment
The Biden Administration’s push for more transparent drug pricing and the potential introduction of price negotiation mechanisms under Medicare could exert downward pressure on Eliquis prices, albeit the timing remains uncertain.
Emerging Biosimilars and Alternative Therapies
While Eliquis is not a biologic, the advent of biosimilar-like innovations and newer anticoagulants like factor Xa inhibitors could influence prescribing trends and, consequently, pricing strategies.
Market Penetration and Therapy Differentiation
Enhanced adherence programs, combination therapies, and expanding indications may sustain or increase Eliquis's market share pre-patent expiry, buffering potential price erosions.
Price Projection Outlook (2023-2030)
| Year | Expected Price Range (per 30-tablet pack) | Rationale |
|---|---|---|
| 2023 | $500 – $600 | Current market positioning; minimal annual changes |
| 2024 – 2025 | $490 – $580 | Slight reductions due to payer negotiations and discounting strategies |
| 2026 – 2027 | $460 – $560 | Continued market stabilization before patent cliff; inflation adjustments |
| 2028 – 2029 | $440 – $540 | Pre-generic entry preparations; possible volume-driven discounts |
| 2030+ | $200 – $300 (post-generic entry) | Significant price reductions anticipated post-patent expiry, aligned with historical trends of similar drugs |
The sharp decline post-2030 aligns with the typical 60–80% price reduction observed when generics first enter the market [4].
Strategic Implications and Recommendations
- Patent extension opportunities: Bristol-Myers Squibb/Pfizer can pursue patent extensions or formulation innovations to delay generic competition.
- Pricing optimization: Maintaining premium pricing through clinical differentiation, while preparing for strategic cost management post-patent expiry.
- Market expansion: Focus on increasing indications and geographic penetration to capitalize on current exclusivity.
- Post-expiry strategies: Prepare for market share retention through biosimilar development and value-based pricing models once generics enter.
Key Takeaways
- The current pricing premium of Eliquis remains justified by its clinical profile and patent protection, with retail prices around $16–$20 per tablet.
- Future prices will stabilize with minor fluctuations until patent expiration, after which significant price reductions (60–80%) are inevitable.
- The competitive landscape and regulatory environment will influence pricing strategies, requiring ongoing market intelligence.
- Proactive patent management and innovation are essential to extend Eliquis’s market dominance.
- Companies should prepare for a post-patent era by developing biosimilars or alternative anticoagulant formulations to regain market traction.
FAQs
1. When is Eliquis expected to face generic competition?
Patent protections are anticipated to expire around 2030, opening the market for generics that could significantly lower prices [2].
2. How will generics impact Eliquis’s market share?
Generics will likely reduce the brand’s market share by 50–70%, triggering substantial price declines and increased affordability for payers and patients.
3. Are there any regulatory efforts to cap drug prices for Eliquis?
While some policy proposals seek to regulate prices, no concrete measures specifically targeting Eliquis are in place as of yet. Future policies, however, could influence price dynamics.
4. How does Eliquis compare economically to its rivals?
Although priced higher than some competitors, Eliquis’s superior safety and efficacy profiles support its premium positioning, making it cost-effective for certain patient populations.
5. What are potential strategies for Bristol-Myers Squibb and Pfizer to maximize revenue pre- and post-patent?
Pre-patent expiry, their focus should be on market expansion, indication growth, and patent extension. Post-expiry, diversifying with biosimilars, value-based pricing, and new indications can help sustain profitability.
References
[1] GlobalData Healthcare. “Anticoagulant Market Size and Forecast 2022-2027.”
[2] U.S. Food and Drug Administration. “Patent Expiry Dates for Eliquis and Related Market Data.”
[3] IMS Health. “Historical Price Trends Post-Patent Expirations.”
[4] Pharmaceutical Market Dynamics Report, 2022.
Note: Data points are illustrative, gathered from industry reports, regulatory filings, and market analyses relevant as of early 2023.
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