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Last Updated: December 19, 2025

Drug Price Trends for NDC 00299-3822


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Best Wholesale Price for NDC 00299-3822

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions
Drug Name Vendor NDC Count Price ($) Price/Unit ($) Dates Price Type
>Drug Name >Vendor >NDC >Count >Price ($) >Price/Unit ($) >Dates >Price Type
Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Market Analysis and Price Projections for NDC: 00299-3822

Last updated: July 29, 2025


Introduction

Analyzing the market landscape and projecting future pricing for pharmaceutical products is critical for stakeholders involved in manufacturing, distribution, and investment. The National Drug Code (NDC): 00299-3822 corresponds to a specific drug product within the U.S. healthcare system, and understanding its market position, competitive environment, pricing dynamics, and potential growth trajectories provides valuable insights for stakeholders.


Drug Identification and Market Context

Product Overview

The NDC 00299-3822 refers to a branded or generic drug product, likely a prescription medication distributed through retail and hospital channels. The first segment, "00299," designates the manufacturer or labeler code assigned by the FDA. The subsequent segments "3822" specify the particular product and formulation.

Market Segments

This product's relevance hinges on its therapeutic class, indications, and market penetration. Suppose it is an oncology agent, anti-inflammatory, or chronic disease medication. Its market would be significantly different from niche or specialty drugs tied to rare indications.

Regulatory Status

As an FDA-approved drug, its regulatory standing influences market dynamics—e.g., exclusivity periods, patent protections, and potential for biosimilar entry. Patent life, exclusivity terms, and pending generic approvals shape the competitive environment.


Current Market Conditions

Market Size and Demand

The demand for the drug hinges on its approved indications, patient population, and treatment guidelines. For example, if it's used for a prevalent chronic disease like diabetes, the market could span millions of patients, translating into a robust revenue stream.

Competitive Landscape

Competitive pressures include generic versions, biosimilars, and alternative therapies. The entry of generics typically leads to substantial price erosion, impacting profit margins.

Pricing Benchmarks

Current prices are influenced by wholesale acquisition costs (WAC), Medicaid and Medicare reimbursement rates, and private insurance negotiations. The U.S. average wholesale price (AWP) provides a benchmark but often does not reflect net prices after discounts and rebates.

Distribution and Reimbursement

Insurance coverage, formulary placement, and prior authorization procedures influence sales volumes and margins. PBMs (Pharmacy Benefit Managers) wield significant power over net reimbursement rates.


Pricing Dynamics and Historical Trends

Historical Price Trends

Over recent years, drug prices in the U.S. have exhibited varied patterns—some ascending due to research and development (R&D) recoupment, others declining post-patent expiry due to generics.

Impact of Patent Expiry

Patent expiration typically triggers sharp price declines, often exceeding 80%, as generics enter the market. The timing of patent cliff impacts strategic planning.

Rebate and Discount Practices

Rebates negotiated between manufacturers and payers significantly affect net prices. These discounts complicate straightforward price projections.

Cost-Driven Pricing Factors

Manufacturing costs, R&D investments, and regulatory compliance influence baseline pricing. Price elasticity tends to be moderate in essential or life-saving drugs.


Future Price Projections and Market Trends

Impact of Patent Expiry and Biosimilar Entry

If NDC: 00299-3822 is a biologic or specialty drug nearing patent expiration, significant price erosion is anticipated within the next 1-3 years. Conversely, if it remains under patent, its pricing may sustain or modestly ascend, factoring inflation and R&D recoveries.

Market Growth Drivers

Expansion in indication approvals, label expansions, and rising prevalence of target diseases will support sales volume growth, potentially influencing pricing strategies.

Regulatory Developments

Policy shifts such as increased biosimilar approvals, value-based pricing models, or drug importation policies could compress pricing margins.

Reimbursement and Value-Based Agreements

Increasing adoption of outcomes-based arrangements may introduce tiered or performance-linked pricing, influencing average transaction prices.

Potential Disruption by Biosimilars or Generics

Market entry by biosimilars can reduce prices by 20-30% within 1-2 years of approval if the drug is biologic, with generic competition exerting even more profound effects on older, small-molecule drugs.


Stakeholder Impact and Strategic Implications

Manufacturer Strategies

Forecasting future prices and volumes is vital for planning R&D investments, market entry timing, and pricing strategies. Maintaining exclusivity rights remains critical in maximizing revenue.

Payer and Buyer Strategies

Insurance companies and PBMs will adjust formulary strategies based on pricing trends, seeking cost-effective options while balancing access.

Investors and Market Analysts

Projected pricing trajectories influence valuation models, M&A activity, and R&D investment considerations.


Key Factors Influencing Price Projections

Factor Impact Outlook
Patent status Patent expiration leads to price decline Pending, unless extended via new patents or formulation rights
Competitive landscape Entry of generics/biosimilars reduces prices Likely in 1-3 years for biologics; varies by drug class
Regulatory decisions Approvals/extensions influence market exclusivity Future approvals or restrictions can shift pricing trajectory
Reimbursement policies Value-based agreements can cap or enhance prices Trend towards negotiation-based pricing
Indication expansion Increased demand sustains or elevates prices Potential for volume-driven price inflation

Projections Summary

  • Short-term (1-2 years):
    If patent protection persists, expect stable or modest price increases (~2-5%) driven by inflation, demand growth, or value-based agreements. Conversely, impending patent expiry could trigger price reductions of 70-80%, aligning with generic entry trends.

  • Medium-term (3-5 years):
    Prices will likely stabilize at lower levels post-generic/biosimilar entry, unless differentiation through improved formulations or indications is achieved, which could sustain higher prices.

  • Long-term (5+ years):
    A mature market with multiple generics or biosimilars could compress prices further, with net revenues dominated by volume rather than unit price. Strategic options include drug reformulation or license extensions.


Key Takeaways

  • Patent and Regulatory Status Are Crucial: The expiration date of exclusivity protections predominantly shapes near-term pricing. Monitoring patent cliffs and regulatory approvals is vital for accurate forecasts.

  • Market Penetration and Competition Define Price Trajectory: Entry of biosimilars or generics can reduce prices by 70-80%, necessitating proactive strategic planning.

  • Volume Growth Can Offset Lower Prices: Expansion in indication approvals and increased disease prevalence can sustain revenue even with declining unit prices.

  • Reimbursement Strategies Influence Net Revenue: Outcome-based agreements and formulary positioning significantly affect the realized prices.

  • Ongoing Policy Trends Are Pivotal: Policy moves favoring biosimilars, importation, or drug price regulation may further depress prices.


FAQs

1. What is the typical impact of patent expiration on drug prices?
Patent expiration generally results in a sharp price decline—often 70-80%—as generic or biosimilar competitors enter the market, eroding the original product’s market share and pricing power.

2. How do biosimilars influence the pricing landscape?
Biosimilars introduce competition to biologic drugs, leading to reduced prices, typically 20-30% below reference biologics. Their market entry accelerates overall price erosion in the biologic segment.

3. What factors could delay price erosion post-patent expiry?
Extended patent protections through supplementary patents, formulation patents, or market exclusivity agreements can delay generic or biosimilar entry, maintaining higher prices longer.

4. How do reimbursement policies affect drug pricing?
Reimbursement models, especially value-based agreements, can tie payment levels to treatment outcomes, influencing net prices and encouraging negotiated discounts or bonuses.

5. What strategic considerations should companies have regarding future pricing?
Manufacturers should monitor patent cycles, invest in formulation innovations, explore indication expansion, and align with policy shifts to optimize revenue streams amid evolving price pressures.


References

[1] U.S. Food and Drug Administration. National Drug Code Directory. URL: https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-ndc-directory

[2] IQVIA Institute. The Global Use of Medicine in 2020 and Outlook to 2024.

[3] Government and Private Sector Reports on Drug Patent Expirations and Biosimilar Market Trends.

[4] Centers for Medicare & Medicaid Services. Reimbursement Data and Policy Frameworks.

[5] MarketResearch.com. Pharmaceutical Pricing and Reimbursement Analysis.


In conclusion, precise market and price forecasts for NDC: 00299-3822 depend on specific attributes such as patent status, therapeutic class, and competitive developments. Stakeholders should integrate current trends with regulatory and competitive insights to formulate informed strategies, leveraging diversification, innovation, and policy navigation to optimize value amid evolving market conditions.

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