Last updated: February 17, 2026
What is NDC 00093-5528?
NDC 00093-5528 identifies a specific pharmaceutical product. Based on available databases, this NDC corresponds to Methylprednisolone Sodium Succinate Inj, 125 mg/5 mL. It is an injectable steroid used primarily for severe allergic reactions, inflammation, and autoimmune conditions.
Market Size and Demand Dynamics
Current Market Composition
- Therapeutic Category: Corticosteroids
- Indications: Allergic reactions, asthma, autoimmune diseases
- Administration Route: Intravenous/Intramuscular injection
- Prescriber Base: Hospital pharmacies, clinics, emergency departments
Global Market Size
- The global corticosteroid market was valued at approximately $4.9 billion in 2022.
- Projected CAGR for corticosteroids: 3.5% to 4% (2023–2030), driven by increased autoimmune and allergic condition prevalence.
- Injectable corticosteroids account for around 25–30% of the total corticosteroid market by value.
U.S. Market Insights
- In 2022, U.S. corticosteroid injections contributed an estimated $1.2 billion.
- Annual prescription volume for methylprednisolone injections: ~1.5 million units.
- Institutional use dominates, especially in hospitals and emergency settings.
Competitive Landscape
Key Competitors
| Company |
Product Name |
Strengths |
Market Share (Est.) |
| Pfizer |
Solu-Medrol |
Established presence, broad distribution |
35% |
| Teva |
Methylprednisolone |
Cost competitiveness, global reach |
20% |
| Sandoz (Novartis) |
Generic methylprednisolone |
Price advantage |
15% |
| Others |
Various generics |
Niche or regional distributors |
30% |
Generic Market Penetration
Most methylprednisolone injections are available as generics, which constitute around 70–80% of volume. Brand name Solu-Medrol maintains premium pricing due to brand recognition.
Pricing Overview and Projections
Current Price Points
- Average Wholesale Price (AWP) for a 125 mg/5 mL vial: $18–$22.
- Estimated Transaction Price (post-discounts): $12–$16 per vial.
- Reimbursement Rates: Hospitals typically reimbursed at 10–20% above AWP under Medicare/Medicaid.
Historical Price Trends
- Price declines since 2010: approximately 15% over the past decade due to increased generics.
- Stabilization post-2020 with occasional rises following supply disruptions and inflation adjustments.
Forecast for 2023–2028
| Year |
Price Range (per vial) |
Key Drivers |
| 2023 |
$12.50–$16 |
Market saturation, cost competition |
| 2024 |
$12.50–$15.50 |
Possible supply chain disruptions, inflation |
| 2025 |
$13–$16 |
Market normalization, demand stability |
| 2026 |
$13–$16.50 |
Slight inflation impact |
| 2027 |
$13.50–$17 |
Potential price increases in shortages |
| 2028 |
$14–$17.50 |
Continued demand, inflation hits |
Regulatory and Policy Impacts
- FDA approvals for new formulations or biosimilars could influence pricing.
- Medicare/Medicaid policies governing reimbursements affect net revenue.
- Supply chain issues (e.g., raw material shortages) have the potential to cause price volatility.
Key Market Risks
- Increased use of biosimilars or generics reduces prices.
- Supply disruptions due to manufacturing issues or regulatory actions.
- Pricing pressure from hospital buying groups and bulk procurement initiatives.
- Regulatory changes impacting reimbursement and drug classification.
Summary
The methylprednisolone sodium succinate injection (NDC 00093-5528) functions within a mature, high-volume market increasingly impacted by generic competition. Current prices are stable but subject to downward pressure from market saturation and supply factors. Conservative projections estimate prices per vial between $12 and $16 through 2028, with potential upward adjustments in the case of supply shortages or regulatory-driven demand shifts.
Key Takeaways
- The drug operates in a mature, generic-dominant market with steady demand.
- Pricing has declined over the past decade due to generics but may stabilize.
- Supply chain issues and regulatory changes are the main risks influencing future pricing.
- Market growth remains aligned with global autoimmune and allergic condition prevalence increases.
- Reimbursement policies significantly impact net revenues for manufacturers and distributors.
FAQs
1. How does the availability of biosimilars affect the pricing of NDC 00093-5528?
Biosimilars and generics increase competition, generally driving down prices. As biosimilars for corticosteroids enter the market, prices for existing drugs like methylprednisolone injections will likely decrease further.
2. What are the primary factors influencing future price trends?
Supply chain stability, regulatory policies, healthcare reimbursement schemes, and market competition determine future pricing trajectories.
3. Are there any upcoming regulatory changes that could impact this product?
Possible FDA approvals of biosimilars or changes in Medicaid and Medicare reimbursement policies could affect market dynamics significantly.
4. How does demand in hospitals compare to outpatient clinics for this drug?
Hospital use dominates due to the drug’s injectable form used in emergency and severe cases, leading to higher volumes and stabilized demand.
5. What is the impact of global market expansion on pricing?
Expanding markets in Europe and Asia can influence global demand, but pricing remains driven by local competition, regulations, and healthcare policies.
Citations
[1] IQVIA, "Corticosteroids Market Report," 2022.
[2] FDA Database, "NDC Directory," 2023.
[3] MarketWatch, "Global Corticosteroid Market Analysis," 2023.
[4] Medicare Pricing & Reimbursement Data, 2022.
[5] Sanford C. Bernstein, "Generic Drug Pricing Trends," 2022.
