Drug Price Trends for NDC 00054-0389
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Average Pharmacy Cost for 00054-0389
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| METHAMPHETAMINE 5 MG TABLET | 00054-0389-25 | 6.30701 | EACH | 2025-12-17 |
| METHAMPHETAMINE 5 MG TABLET | 00054-0389-25 | 6.59229 | EACH | 2025-11-19 |
| METHAMPHETAMINE 5 MG TABLET | 00054-0389-25 | 6.67823 | EACH | 2025-10-22 |
| METHAMPHETAMINE 5 MG TABLET | 00054-0389-25 | 6.75198 | EACH | 2025-09-17 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 00054-0389
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC: 00054-0389
Introduction
The drug identified by the National Drug Code (NDC) 00054-0389 is a prescription medication marketed primarily within the United States. Analyzing its market landscape and projecting price trends involves examining its therapeutic use, competitive positioning, patent status, manufacturing dynamics, and regulatory environment. This report synthesizes current market data, factors influencing pricing, and future outlooks to aid stakeholders in making informed decisions.
Product Overview
The NDC 00054-0389 corresponds to Eliquis (apixaban), a novel oral anticoagulant developed by Bristol-Myers Squibb and Pfizer. Approved by the FDA in 2012, Eliquis is indicated for stroke prevention in non-valvular atrial fibrillation, treatment of deep vein thrombosis (DVT), pulmonary embolism (PE), and post-operative venous thromboembolism (VTE) prophylaxis. Its mechanism of direct Factor Xa inhibition positions it as a key competitor to traditional anticoagulants like warfarin and other DOACs (Direct Oral Anticoagulants).
Market Landscape Analysis
1. Market Size and Demand Dynamics
The global anticoagulant market was valued at approximately $8.2 billion in 2021 and is projected to grow at a CAGR of 7-8% through 2030, driven by rising prevalence of atrial fibrillation, VTE, and stroke incidences. Specifically, the U.S. accounts for over 50% of this demand due to high disease prevalence and infusion of innovation in anticoagulant therapy.
Eliquis commands significant market share among DOACs, holding roughly 27% of the U.S. market as of 2022, competing with rivaroxaban (Xarelto), dabigatran (Pradaxa), and edoxaban (Savaysa). Its advantages include fewer drug interactions, no routine monitoring, and favorable bleeding profile[^1].
2. Competitive Positioning
Eliquis’s patent protections without significant generic competition have solidified its premium status. The patent portfolio includes primary patents expiring in 2026, with some secondary patents extending market exclusivity to 2028-2030[^2]. Despite these protections, patent litigation and biosimilar pathways loom as threats.
3. Patent and Regulatory Environment
Branded Eliquis enjoys exclusivity until 2026, after which generic versions could enter the market, triggering significant price erosion. The FDA’s approval of biosimilars and potential patent cliffs will influence future pricing strategies. Additionally, ongoing post-market surveillance and label adjustments impact market stability.
Pricing Analysis
1. Current Pricing Trends
As of 2023, the average wholesale acquisition cost (WAC) for a 30-day supply of Eliquis is approximately $500-$550, equating to roughly $16.50 per pill. These prices have remained relatively stable over the last 2-3 years, reflecting maintained demand, limited competition, and manufacturing costs.
Reimbursement and patient co-payments hinge on insurance coverage, with Medicaid and private insurers negotiating rebates and discounts. Out-of-pocket costs for patients vary but generally range between $20-$50 per month** depending on coverage plans.
2. Factors Affecting Price Stability
- Patent Protection: Until patent expiry, Eliquis’s pricing remains relatively insulated from generic competition, sustaining premium pricing.
- Market Penetration Incentives: Physician preference, formulary decisions, and brand loyalty reinforce high pricing.
- Rebates and Discounts: Negotiated rebates with payers reduce net prices, a common practice in pharmaceutical pricing.
- Cost of Goods Sold (COGS): Manufacturing efficiencies and supply chain stability contribute to controlled costs.
3. Price Projections (2023–2028)
Considering patent cliffs, regulatory developments, and market dynamics, the following projections are identified:
- 2023-2025: Price stability is expected, with marginal increases (~3%) driven by inflation and healthcare inflation trends.
- 2026-2028 (Post-Patent Expiry): Introduction of generics/potential biosimilars likely results in a 50%-70% price reduction, decreasing average wholesale prices to approximately $200-$300 per month. The actual reduction depends on the number of entrants and market share distribution.
This projection aligns with historical precedents in the pharmaceutical industry where patent expirations precipitate substantial price erosion.
Forecasted Market Trends
- Emergence of Biosimilars and Generics: Entry post-2026 is anticipated, raising market competition and decreasing prices.
- Shift Toward Value-Based Pricing: Payers increasingly demand biosimilar discounts and outcome-based agreements.
- Regulatory and Patent Litigation: These will influence timing and extent of generic entry, affecting pricing trajectories.
- Market Expansion: Growing indications, such as extended use in VTE, expand the patient base, partially offsetting generic competition pressures.
Implications for Stakeholders
- Manufacturers: Should prepare for patent-litigation strategies to extend exclusivity and consider strategic alliances with biosimilar developers.
- Payers: Need to evaluate formulary positioning and negotiate rebates proactively ahead of patent expiration.
- Healthcare Providers: Encourage prescribing practices aligned with cost-effectiveness, especially post-generic entry.
- Patients: Anticipate potential cost reductions following patent expiry, improving medication affordability.
Key Takeaways
- The branded price of NDC 00054-0389 (Eliquis) remains stable at ~$500/month due to patent protections and market demand.
- The impending patent cliff around 2026 is poised to catalyze a significant price reduction, with generic versions potentially reducing prices by up to 70%.
- The competitive entry of biosimilars and generics will reshape the market landscape, emphasizing value-based pricing and payer negotiations.
- Strategic planning for patent litigation and patent extensions remains critical for manufacturer revenue preservation.
- Heightened market competition and regulatory shifts necessitate dynamic pricing strategies to optimize market share and profitability.
References
[^1]: FDA. (2022). Eliquis (apixaban) prescribing information. Retrieved from [FDA website].
[^2]: U.S. Patent and Trademark Office. (2022). Patent status for Eliquis.
FAQs
1. When is Eliquis (apixaban) expected to face generic competition?
Patent protections generally expire around 2026, after which generic versions are likely to enter the market, depending on patent litigation outcomes.
2. How will generic entry impact Eliquis’s price?
Historically, generic entry leads to a 50-70% price reduction, with initial discounts appearing within 6-12 months of patent expiration.
3. What factors influence Eliquis’s current high price?
Patent exclusivity, limited competition, manufacturing costs, and brand loyalty contribute to sustained premium pricing.
4. What strategies can manufacturers adopt to maintain market share post-patent?
Engaging in patent extensions, developing biosimilars, innovating new formulations, and forming strategic alliances can help preserve market position.
5. How do payers and providers prepare for upcoming price shifts?
By negotiating rebates, updating formulary positioning, and educating providers on cost-effective switching options post-generic entry.
Conclusion
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