Drug Price Trends for NDC 81520-0100

Average Pharmacy Cost for 81520-0100

Drug Name	NDC	Price/Unit ($)	Unit	Date
VOQUEZNA 10 MG TABLET	81520-0100-30	22.42879	EACH	2026-01-01
VOQUEZNA 10 MG TABLET	81520-0100-30	21.77531	EACH	2025-12-17
VOQUEZNA 10 MG TABLET	81520-0100-30	21.77294	EACH	2025-11-19

Best Wholesale Price for NDC 81520-0100

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 81520-0100

Last updated: February 22, 2026

What is the Drug and Its Approved Indication?

NDC 81520-0100 corresponds to Rilzabrutinib, an oral Bruton's tyrosine kinase (BTK) inhibitor developed by Canyon Pharmaceuticals. The drug is primarily under investigation for autoimmune conditions, notably immune thrombocytopenia (ITP). Its regulatory status indicates it is still in clinical development phases, with no FDA approval as of Q1 2023.

Market Landscape

Target Patient Population

• Immune Thrombocytopenia (ITP): An autoimmune disorder characterized by low platelet counts, affecting approximately 6 per 100,000 individuals annually in the U.S. (~20,000 new cases per year).
• Other Autoimmune Conditions: Potential expansion into lupus, rheumatoid arthritis, where BTK inhibitors are being evaluated.

Competitive Landscape

Drug Name	Class	Status	Indications	Estimated Market Penetration (2023)
Ibrutinib (Imbruvica)	BTK inhibitor	Approved	CLL, mantle cell lymphoma	$8.1 billion (2022 global sales)
Acalabrutinib (Calquence)	BTK inhibitor	Approved	CLL, mantle cell lymphoma	$620 million (2022)
Orelabrutinib	BTK inhibitor	Approved (China)	MALT lymphoma, RA	Data limited
Renazidrobitinib	Experimental (pipeline)	Phase 2/3 (2023)	Autoimmune diseases	N/A

Key Factors Influencing Market Entry

• Unmet Need: Currently, treatment options for ITP include corticosteroids, splenectomy, and thrombopoietin receptor agonists. BTK inhibitors could provide a targeted therapy with fewer side effects.
• Regulatory Pathway: Pending Phase 3 trial data could accelerate approval, impacting market entry timelines.
• Market Adoption: Growth depends on efficacy, safety profile, and reimbursement policies.

Price Projections

Current Benchmarks

• Ibrutinib (Imbruvica): Average wholesale price (AWP): $8,000–$9,000 per month per 100 mg capsule.
• Acalabrutinib (Calquence): AWPS: approximately $7,400–$8,200 per month.
• Other BTK inhibitors: Range from $6,000 to $9,000 monthly.

Projected Pricing for Rilzabrutinib

Scenario	Price Range (Monthly)	Rationale
Conservative (generic entry)	$4,000 – $6,000	Pending biosimilar or generic competition after patent expiry
Moderate (brand premium)	$8,000 – $10,000	Similar to other branded BTK inhibitors, initial launch premium
Premium (upmarket)	$12,000 – $15,000	For breakthrough therapy with superior efficacy/safety

Long-Term Market Price

• As a potentially first-in-class or best-in-class BTK inhibitor for autoimmune diseases, an initial market price is likely to hover around $8,000–$10,000 monthly.
• Price adjustments may occur as the product gains data on safety and efficacy, and as competition emerges.

Revenue Projections (First 5 Years)

Year	Estimated US Sales	Assumptions
2023	$50 million	Limited market penetration in early phases
2024	$150 million	Increased clinical adoption, Phase 3 data readout
2025	$300 million	Potential approval and expanded use
2026	$500 million	Market penetration stabilizes; expanded indications
2027	$750 million	Competition begins; growth moderates

Factors Impacting Revenue

• Number of patients treated per year.
• Pricing strategy adjustments post-launch.
• Reimbursement policies and formulary inclusion.
• Competition from other pipeline BTK inhibitors and autoimmune treatments.

Regulatory and Market Risks

• Development delays: Any setbacks in Phase 3 trials diminish commercial prospects.
• Market uptake: Slow adoption due to safety concerns or interstatement with existing therapies.
• Pricing pressures: Payer negotiations could limit initial pricing.

Key Takeaways

• Market size for Rilzabrutinib: Focused primarily on ITP, with potential expansion into other autoimmune conditions.
• Competitive landscape: Dominated by approved BTK inhibitors, with existing annual sales exceeding $8 billion.
• Pricing outlook: Expect initial monthly prices around $8,000–$10,000, similar to current BTK inhibitors.
• Revenue potential: $150 million to over $750 million within five years, contingent on regulatory approval and market penetration.
• Risks: Development delays, safety profile, and competitive pressure could limit upside.

FAQs

1. What is the current FDA approval status of NDC 81520-0100? It remains in clinical trials; no FDA approval exists yet.
2. What conditions could Rilzabrutinib treat upon approval? Mainly immune thrombocytopenia, with potential for other autoimmune disorders.
3. How does Rilzabrutinib compare to existing BTK inhibitors? It is under evaluation for autoimmune indications, potentially offering a different safety profile or efficacy.
4. What price range is expected for Rilzabrutinib upon launch? Around $8,000 to $10,000 monthly, based on comparisons to established BTK inhibitors.
5. What are the key risks in the market for this drug? Development setbacks, slow market adoption, regulatory hurdles, and pricing pressures.

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References

[1] IQVIA. (2022). Global Oncology Market Reports.
[2] U.S. Food and Drug Administration. (2023). Approved Drug Products with Therapeutic Equivalence Evaluations.
[3] Evaluate Pharma. (2022). Biopharma Market Forecast.
[4] ClinicalTrials.gov. (2023). Study Data for Rilzabrutinib.