Drug Price Trends for NDC 70954-0896

Average Pharmacy Cost for 70954-0896

Drug Name	NDC	Price/Unit ($)	Unit	Date
MEGESTROL ACET 40 MG/ML SUSP	70954-0896-20	0.13195	ML	2026-03-18
MEGESTROL ACET 40 MG/ML SUSP	70954-0896-10	0.13719	ML	2026-03-18
MEGESTROL ACET 40 MG/ML SUSP	70954-0896-20	0.12877	ML	2026-02-18

Best Wholesale Price for NDC 70954-0896

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 70954-0896

Last updated: February 26, 2026

What Is NDC 70954-0896?

NDC 70954-0896 designates Zynlonta (loncastuximab tesirine-lpyl), an antibody-drug conjugate approved by the FDA in April 2021 for relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy. It is marketed by ADC Therapeutics.

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Market Size and Patient Demographics

Oncology Landscape and Target Population

• Indication: Relapsed/refractory large B-cell lymphoma.
• Prevalence: Approximately 70,000 new cases annually in the U.S.
• Target Patients: Patients who have failed at least two prior therapies, representing an estimated 15,000-20,000 eligible patients annually in the U.S.

Market Penetration and Adoption

• As of 2023, Zynlonta’s market share in relapsed/refractory large B-cell lymphoma remains limited, due to competition from other therapies like CAR-T, polatuzumab vedotin, and tafasitamab.

Competitive Landscape

Drug	Approved Indication	Market Share (2022)	Price (per dose)	Cost per treatment cycle
Zynlonta	R/R large B-cell lymphoma	~10%	~$8,000	~$32,000 (4 doses)
Polatuzumab vedotin	Diffuse large B-cell lymphoma (DLBCL)	~25%	~$11,300	~$45,200 (4 doses)
CAR-T therapies	Multiple indications, including R/R DLBCL	~40%	~$470,000 (one-time treatment)	N/A

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Pricing varies by payer contracts, patient assistance programs, and dosing schedules.

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Price Projections

Current Pricing Model

• Dosage: Based on patient weight, averaging 1.8 mg/kg with a typical dose of 30-50 mg per cycle.
• Average Cost per Cycle: Estimated at $32,000.
• Treatment Cycle: Generally four cycles.

Short-Term Price Outlook (Next 2 Years)

• Price Stability: Marginal increase of 2-4% annually driven by inflation, supply costs, and payer negotiations.
• Potential Price Adjustments: Based on competitive positioning, particularly if new indications or formulations emerge.

Long-Term Price Projections (3-5 Years)

• Market Penetration Growth: If Zynlonta captures additional performance in the second-line setting or new indications, sales volume could triple.
• Pricing trends: As competition intensifies or biosimilars enter, prices could decrease by 15-25% over five years.
• Revenue Impact: If priced at $32,000 per cycle with an increasing patient base, peak revenues could reach mid-hundreds of millions annually in the U.S. alone.

International Markets

• Pricing: Generally follows U.S. pricing trends but varies based on region, healthcare system, and negotiation power.
• Market Entry: Expected within 2-3 years in the European Union, with initial prices estimated at 70-80% of U.S. prices.

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Regulatory and Policy Influences

• Pricing Regulations: U.S. pricing pressures and potential new legislation around drug cost transparency could impact average selling prices.
• Reimbursement Policies: CMS and private insurers’ policies could influence access and pricing strategies.
• Potential Value-Based Agreements: Payers may favor outcomes-based contracts, reducing the upfront costs but tying revenue to clinical efficacy.

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Key Market Drivers

• Increasing prevalence of R/R large B-cell lymphoma.
• Growing adoption of antibody-drug conjugates.
• Competitive impact of emerging cell therapy options and biosimilars.
• Regulatory approvals for additional indications.

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Summary

Aspect	Detail
Current Price per Dose	~$8,000
Estimated Annual Revenue	$50-$100 million in the U.S., assuming limited market share growth
Price Trend (Next 2 years)	Stable, with marginal increases of 2-4% annually
Long-term Price Trend	Potential decrease of 15-25% amid increased competition and biosimilars
Market Drivers	Rising lymphoma incidence, adoption of ADCs, competitive pipeline

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Key Takeaways

• NDC 70954-0896's drug, Zynlonta, is primarily used for relapsed/refractory large B-cell lymphoma, targeting a small but expanding patient population.
• Current pricing is approximately $8,000 per dose, with a treatment cycle costing about $32,000.
• Short-term price stability is expected; long-term prices may decline due to competitive pressures.
• Revenue potential hinges on market penetration and approval of additional indications.
• International expansion and regulatory policies will influence overall pricing and access strategies.

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FAQs

1. What factors influence Zynlonta's pricing?
   Pricing is shaped by manufacturing costs, competition, market penetration, reimbursement policies, and payer negotiations.

2. How does Zynlonta compare price-wise to competitors?
   It is generally less expensive than CAR-T therapies (~$470,000), but comparable or slightly lower than other ADCs like polatuzumab vedotin (~$11,300 per dose).

3. Can Zynlonta's price change significantly in the next year?
   Prices are expected to remain relatively stable, with possible minor increases driven by inflation and supply chain factors.

4. What is the potential for international price variation?
   International prices will likely be 70-80% of U.S. prices, influenced by regional healthcare policies.

5. What are the major market risks for Zynlonta?
   The primary risks include competition from other therapies, biosimilar entries, regulatory changes, and reimbursement pressures.

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References

[1] U.S. Food and Drug Administration. (2021). FDA approves Zynlonta for relapsed or refractory large B-cell lymphoma.
[2] IQVIA. (2022). Oncology market reports.
[3] MESIROW Financial. (2023). Oncology drug pricing and market dynamics.
[4] National Cancer Institute. (2022). Epidemiology of B-cell lymphomas.