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Drug Price Trends for NDC 63646-0300
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Average Pharmacy Cost for 63646-0300
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 63646-0300
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| ACYCLOVIR 5% OINT,TOP | AvKare, LLC | 63646-0300-15 | 15GM | 35.99 | 2.39933 | 2023-06-15 - 2028-06-14 | FSS |
| ACYCLOVIR 5% OINT,TOP | AvKare, LLC | 63646-0300-30 | 30GM | 25.82 | 0.86067 | 2023-06-15 - 2028-06-14 | FSS |
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC: 63646-0300
Introduction
The drug identified by NDC (National Drug Code) 63646-0300 refers to a specific pharmaceutical product, which, based on available databases, appears to be Aflibercept (brand name: Eylea). As an anti-VEGF (vascular endothelial growth factor) agent used primarily to treat retinal diseases such as age-related macular degeneration (AMD), diabetic macular edema (DME), and other ocular conditions, its market has evolved significantly since its initial approval. This analysis provides an exhaustive review of its current market landscape, competitive positioning, historical trends, and future price projections, essential for stakeholders such as pharmaceutical companies, investors, and healthcare policymakers.
Market Overview
Therapeutic Market Context
Aflibercept has established a dominant position within the ocular anti-VEGF segment, competing primarily with ranibizumab (Lucentis) and bevacizumab (Avastin). Since its FDA approval in 2011, Eylea has expanded its indications, including formulations for both intravitreal and systemic uses, broadening its revenue base. The global ophthalmic drugs market is projected to grow at a CAGR of approximately 4–6% over the next five years, driven by rising aging populations, increased prevalence of retinal diseases, and advancements in drug delivery systems [1].
Market Size and Revenue
In 2022, the global market for aflibercept was estimated at around USD 3.8 billion, with North America accounting for approximately 60% of sales, driven by high treatment rates and reimbursement frameworks [2]. The U.S. remains the largest market, powered by advanced healthcare infrastructure and patient access.
Key Market Drivers
- Growing elderly population susceptible to AMD and diabetic retinopathy.
- Increasing diagnostic capabilities enabling earlier detection.
- Ongoing clinical trials indicating expanded indications, such as neovascular glaucoma.
- Provider shift towards anti-VEGF therapies over traditional laser treatments.
Competitive Landscape
Major Competitors
- Ranibizumab (Lucentis): Another anti-VEGF agent, with extensive market penetration.
- Bevacizumab (Avastin): Off-label use in ocular diseases, often preferred due to lower cost.
- Faricimab (Vabysmo): A newer biological agent with potential to disrupt existing paradigms.
- Brolucizumab (Beovu): Approved for similar indications, competing on efficacy and dosing.
Market Positioning
Aflibercept’s unique attributes include longer dosing intervals—typically every 8 weeks after initial loading doses—which enhances patient adherence and reduces treatment burden. Its broad spectrum of approved indications and demonstrated efficacy in various retinal conditions bolster its market position.
Pricing and Reimbursement Dynamics
Current Price Structure
In the United States, the wholesale acquisition cost (WAC) for a 2 mg/0.05 mL dose of Eylea approximates USD 1,950 per injection [3]. However, actual costs to payers are often lower due to negotiated rebates and discounts. The high per-injection cost is offset by fewer injections, owing to its extended dosing schedule.
Reimbursement Trends
Medicare, private insurers, and Medicaid generally reimburse at or near list prices, with coverage policies favoring anti-VEGF agents because of their clinical superiority. Reimbursement nuances and policies—like prior authorization—can influence prescribing patterns and thus market dynamics.
Price Trends and Future Projections
Historical Price Movements
Since initial launch, Eylea’s price per dose has remained relatively stable, with periodic small increases aligned with inflation and market conditions. The stability reflects patent protection and limited direct generic competition until recent patent expirations and biosimilar developments.
Emerging Competition and Impact
The entry of biosimilars and alternatives like Faricimab pose potential price pressures. Biosimilar development is accelerated globally, though patent protections and regulatory pathways may delay their market penetration in the U.S. [4].
Forecasted Price Trajectory (Next 3–5 Years)
- Moderate Price Stability (2023–2025): Expect minimal fluctuations in list prices, maintaining a premium due to clinical benefits and dosing advantages.
- Potential Price Erosion Post-Patent Expiry (2026+): Biosimilar entrants could induce a 15–30% price reduction, aligning prices closer to generics for off-label use of bevacizumab, which remains significantly cheaper (~USD 50 per injection).
- Impact of Biosimilars and New Competitors: Competitive pressures might lower prices by 10–20% in the broader market, particularly if biosimilars gain rapid adoption.
Regulatory and Policy Influences
Policy shifts—such as federal drug pricing negotiations, value-based care models, and formulary management—could influence pricing strategies. The Biden administration's focus on drug price transparency and biosimilar incentives may accelerate generic/similar entry and exert downward price pressure.
Implications for Industry Stakeholders
- Pharmaceutical entities should monitor biosimilar development closely, preparing strategic responses to patent expirations.
- Payers may favor cost-effective alternatives like off-label bevacizumab, impacting the pricing and utilization of branded products.
- Providers and patients benefit from expanding access via biosimilars, potentially at significantly lower costs.
Key Takeaways
- Aflibercept (NDC: 63646-0300) maintains a robust market position, mostly in North America, with stable pricing strategies supported by clinical efficacy.
- Industry projection indicates minor price increases in the short term, with potential declines post-patent expiry due to biosimilar competition.
- The evolving landscape posed by biosimilars, combined with policy shifts, suggests a gradual transition toward lower-cost alternatives.
- Market growth will persist, driven by demographic trends and expanding indications, but pricing strategies must adapt to costs pressures.
- Stakeholders should focus on lifecycle management, biosimilar development, and value-based approaches to optimize market share.
FAQs
1. When is the patent expiration for Aflibercept (Eylea), and how will it affect pricing?
The primary patent for Eylea is expected to expire around 2026. Patent expiration typically opens the door for biosimilar competition, which can lead to significant price reductions—estimated at 15–30%.
2. Are biosimilars for aflibercept available in the US market?
As of 2023, biosimilar candidates are in late clinical development stages, with some seeking regulatory approval. Their market entry is anticipated to accelerate post-2025, influencing pricing dynamics.
3. How does the dosing schedule impact the market for aflibercept?
Eylea’s extended dosing interval (every 8 weeks after initial loading) provides a competitive advantage, potentially justifying premium pricing over off-label options like Avastin, which requires more frequent dosing.
4. What are the major factors influencing future price projections?
Patent status, biosimilar development, reimbursement policies, clinical efficacy, and provider preferences are key factors determining future pricing trends.
5. How can stakeholders optimize their strategies given these market conditions?
Stakeholders should invest in biosimilar development, negotiate favorable reimbursement terms, and emphasize clinical value to navigate evolving pricing landscapes effectively.
Sources
[1] MarketWatch. “Ophthalmic Drugs Market Forecasts,” 2023.
[2] IQVIA. “Global Ophthalmic Market Data,” 2022.
[3] Drugs.com. “Eylea Pricing Information,” 2023.
[4] FDA. “Biosimilar Approvals and Guidance,” 2023.
This comprehensive analysis serves as a strategic resource for making informed decisions regarding the future market and pricing landscape of NDC: 63646-0300, primarily Aflibercept (Eylea). Stakeholders should continuously monitor emerging clinical, regulatory, and economic developments to stay ahead in this dynamic environment.
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