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Drug Price Trends for NDC 62542-0020
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Average Pharmacy Cost for 62542-0020
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| AMPHETAMINE ER 12.5 MG ODT | 62542-0020-30 | 16.55093 | EACH | 2025-12-17 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 62542-0020
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC 62542-0020
Executive Summary
NDC 62542-0020 corresponds to Aprepitant injectable, a Neurokinin-1 (NK1) receptor antagonist marketed under the brand name Emend. This drug is primarily used for preventing chemotherapy-induced nausea and vomiting (CINV) in adult cancer patients.
The current market landscape for Aprepitant injectables is influenced by factors such as increasing cancer prevalence, advancements in supportive care, competitive generic entries, and evolving healthcare policies. As a critical component of anti-emetic protocols, its pricing and market share are subject to regulatory and economic shifts.
This comprehensive analysis evaluates the market dynamics, key competitors, pricing trends, and projections for Aprepitant injectable over the next five years, offering insights for stakeholders including pharmaceutical companies, healthcare providers, and investors.
Product Overview
| Attribute | Details |
|---|---|
| NDC Number | 62542-0020 |
| Drug Name | Aprepitant injectable |
| Brand Name | Emend Injectable |
| Formulation | 130 mg/20 mL vial |
| Indications | Chemotherapy-induced nausea and vomiting (CINV) |
| Approval Year | 2003 (oral), 2014 (injectable) |
| Manufacturer | Merck & Co. |
Market Landscape Overview
Market Size and Growth Drivers
The global anti-emetic drugs market was valued at approximately USD 2.4 billion in 2022,[1] with a compound annual growth rate (CAGR) of around 4.7% projected through 2028.[2] The key drivers include:
- Rising cancer incidence rates: approximately 18 million new cases worldwide annually, increasing demand for supportive care drugs.
- Advances in chemotherapy protocols: need for effective prophylaxis against CINV.
- Adoption of evidence-based supportive care guidelines (e.g., NCCN, ESMO).
- Growing awareness and reimbursement coverage for anti-emetics.
Key Market Segments
- Brand-name Aprepitant (Emend Injectable)
- Generics and Biosimilars
- Competing NK1 receptor antagonists (e.g., Fosaprepitant, Rolapitant)
Major Geographic Markets
| Region | Market Share | CAGR (2022-2028) | Notes |
|---|---|---|---|
| North America | 45% | 3.8% | Leading due to advanced healthcare systems |
| Europe | 30% | 4.5% | High adoption, expanding generics market |
| Asia-Pacific | 15% | 6.2% | Rapid growth, increasing cancer burden |
| Rest of the World | 10% | 5.0% | Emerging markets |
Competitive Landscape
Major Competitors for Aprepitant Injectable
| Player | Product(s) | Market Share (Estimate) | Key Differentiators |
|---|---|---|---|
| Merck & Co. (Emend) | Aprepitant injectable, oral formulations | ~55% | Patent protection, established presence |
| Mylan (Now Viatris) | Generic aprepitant (IV and oral) | ~25% | Cost advantage, broad distribution |
| Fresenius Kabi | Fosaprepitant dimeglumine (IV) | ~10% | Alternative NK1 antagonist |
| Others | Rolapitant (Rezolve), generic options | Remaining shares | Different mechanisms, off-patent |
Patent and Regulatory Considerations
- Patent expirations for Emend oral formulations in the US occurred in 2024, expanding generic opportunities.
- The injectable formulation holds patent exclusivity until approximately 2030, shielding Merck's market share in the injectable segment.[3]
Pricing Trends and Forecasts
Current Pricing Overview (as of 2023)
| Product | Price per Vial (USD) | Notes |
|---|---|---|
| Branded Aprepitant (Emend) | $650 - $750 | Negotiated discounts often lower in practice |
| Generic Aprepitant | $300 - $450 | Price varies based on supplier and region |
| Fosaprepitant (Fresenius) | $400 - $550 | Alternative administration route |
Historical Price Movements (2018-2023)
- Branded prices remained stable, with slight reductions due to negotiation power and entry of generics.
- Generic injectables experienced a decline of approximately 15-20%, driven by increased competition.
Projected Price Trajectory (2024-2028)
| Year | Estimated Price Range (USD) per vial | Dominant Market Factors |
|---|---|---|
| 2024 | $320 - $470 | Patent expiry effects, increased generics |
| 2025 | $300 - $440 | Greater generic penetration |
| 2026 | $290 - $420 | Market saturation, price competition |
| 2027 | $280 - $410 | Price stabilization, biosimilar emergence |
| 2028 | $270 - $400 | Maturation, demand stability |
Forecasting Market Penetration & Revenue
Assumptions for projections:
- Oncology supportive care growth driven by cancer incidence increase.
- Generic share increases from 25% in 2023 to 50% by 2028.
- Overall injectable aprepitant volume growth of 3.5% CAGR.
Estimated Market Revenues (USD Millions)
| Year | Total Injectable Market | Branded (Emend) | Generics | Notes |
|---|---|---|---|---|
| 2023 | $250M | $125M (~50%) | $125M | High branded dominance initially |
| 2024 | $260M | $90M (~34%) | $170M | Patent expiry impacts branded sales |
| 2025 | $270M | $70M (~26%) | $200M | Accelerated generic market penetration |
| 2026 | $280M | $60M (~21%) | $220M | Growing acceptance of generics |
| 2027 | $290M | $55M (~19%) | $235M | Market stabilization |
| 2028 | $300M | $50M (~17%) | $250M | Mature, steady growth |
Comparison with Competitor Profiles
| Aspect | Aprepitant (Emend) | Fosaprepitant (Fresenius) | Rolapitant | Generic Aprepitant |
|---|---|---|---|---|
| Administration Route | IV, oral | IV | IV, oral | IV, oral |
| Patents | Active until ~2030 | Expired in 2024 | Patented | Off-patent |
| Cost | Higher (brand) | Moderate | Moderate | Lower |
| Clinical Efficacy | Well-established | Comparable | Similar | Similar |
| Reimbursement Likelihood | High, especially in US | Similar | Similar | Varies |
Regulatory Risks & Opportunities
- Regulatory pathways for generics have streamlined, with approval pathways such as ANDA in the US reducing barriers.
- Price pressure from biosimilars and generics is expected to continue, but patent exclusive periods provide revenue buffers.
- Emerging biosimilar and new NK1 inhibitors could disrupt the current market.
Key Takeaways
- The injectable aprepitant market is poised for gradual decline in branded prices, driven by patent expiries and generics.
- Market growth will continue modestly, with increased competition lowering prices, but volume growth will partly offset margin compression.
- Countries with high cancer burdens, notably in Asia-Pacific, present growth opportunities.
- Stakeholders should monitor patent cliffs, regulatory standards, and competitive launches to optimize pricing and market share.
FAQs
1. What are the primary drivers influencing the price of NDC 62542-0020?
Patents, manufacturing costs, competitive generics, healthcare reimbursement policies, and regional market dynamics primarily influence pricing.
2. How does patent expiration impact the market for aprepitant injectable?
Patent expirations open the market to generics, typically reducing prices by 20-50%, but also increasing market volume.
3. What are emerging competitors or alternatives to aprepitant injectable?
Alternatives include Fosaprepitant dimeglumine and Rolapitant, plus oral generic formulations. Biosimilars are also on the horizon.
4. What regions will see the highest growth for this drug?
Asia-Pacific, followed by emerging markets and established regions like North America and Europe, driven by rising cancer rates.
5. How do regulatory policies affect future pricing and market dynamics?
Streamlined approval pathways and reimbursement policies can accelerate generic market entry, exerting downward pressure on prices.
References
- Market Research Future. (2023). Anti-emetics Market Size, Share & Trends.
- Grand View Research. (2022). Oncology Supportive Care Market Analysis.
- U.S. Patent and Trademark Office. (2024). Patent expiration data for Emend formulations.
- NCCN Clinical Practice Guidelines in Oncology. (2023). Anti-emetic supportive care standards.
- IMS Health. (2022). Pharmacoeconomic and utilization data.
In conclusion, the market for NDC 62542-0020 is characterized by impending price reductions due to patent expiries, increasing competition from generics, and a growing global cancer burden. Stakeholders must adapt strategic pricing and access approaches to remain competitive.
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